T.p.48

Acoustic Radiation Force Impulse (ARFI)-Imaging is a non-invasive ultrasound-based operator independent elastography method that assesses tissue stiffness. ARFI mechanically excites tissues with localized impulsive radiation resulting in shear wave propagation (m/s) away from the region of excitation. Shear wave velocity (SWV) increases when tissue is stiffer, and in muscle disorders, this may be related to either fibrosis or edema. Here we address the sensitivity and specificity of ARFI-imaging to changes in the individual muscles of patients with collagen 6 myopathy (COL6) and LAMA2 related muscular dystrophy (LAMA2), as a reflection of disease progression over 1year.

Source: Neuromuscular Disorders - October 1, 2014 Category: Neurology Authors: , C. Vuillerot, D. Nguyen, K. Yang, S. Auh, S. Donkervoort, K. Meilleur, M. Leach, M. Jain, A. Rutkowski, C. Bönnemann Source Type: research