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Total 125 results found since Jan 2013.

Uraemic sarcopenia: aetiology and implications
The term uraemic myopathy has been used loosely to describe the skeletal muscle abnormalities in uraemic patients. However, it does not fully explain the observed abnormalities as recent research has documented a normal skeletal muscle physiology in the presence of reduced muscle force, selective structural changes and significant muscle wasting. Ageing is associated with sarcopenia (muscle wasting) and an increase in the prevalence of chronic kidney disease (CKD), which accelerates the normal physiological muscle wasting. Similar to sarcopenia, muscle wasting in uraemic patients appears to be the hallmark of the disease a...
Source: Nephrology Dialysis Transplantation - August 27, 2014 Category: Urology & Nephrology Authors: Fahal, I. H. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

Continuous Venovenous Hemodiafiltration for Hyperlactatemia Caused by Telbivudine in a Patient with Chronic Hepatitis B: A Case Report and Update Review
Abstract Though telbivudine has been reported causing myopathy and elevating creatine kinase (CK), there is still few reports on telbivudine and hyperlactatemia in patients with chronic hepatitis B. Here we report the case of hyperlactaemia during telbivudine treatment. A 26‐year‐old Chinese origin man has been received telbivudine antiviral treatment for chronic hepatitis B since 3 July, 2011, and found the CK was 68 U/L before the anti‐viral treatment. After 3 months of therapy, he generally felt nausea and vomited frequently. The CK checked in local clinic was up to 222 U/L (upper limit of normal 170 U/L). However...
Source: Chinese Journal of Digestive Diseases - June 1, 2014 Category: Gastroenterology Authors: Yan‐Hong Wang, Ben‐Quan Wu, Hui Liu Tags: Case Report Source Type: research

Should statins be used to prevent cardiovascular disease in patients on hemodialysis?
Abstract There now exists current evidence that the initiation of statin therapy in patients on hemodialysis does not provide the same cardiovascular benefit as in non-hemodialysis patients. The KDIGO guidelines suggest not to initiate statin therapy in hemodialysis-dependent CKD patients, but to continue therapy in patients who are already on a statin at the time of hemodialysis initiation. A closer monitoring of myopathy is warranted for hemodialysis patients on a statin therapy. PMID: 25276990 [PubMed - in process]
Source: CANNT Journal - April 1, 2014 Category: Urology & Nephrology Authors: Hoi S, Battistella M Tags: CANNT J Source Type: research

Investigation of Factors Affecting the Six‐Minute Walk Test Results in Hemodialysis Patients
Abstract Renal anemia, uremic myopathy, and malnutrition are some of the factors that affect the results of the 6‐minute walk test (6MWT) in hemodialysis patients. We hypothesized that skeletal muscle dysfunction caused by skeletal myolysis, protein hypercatabolism, and mitochondrial deficiency are strongly related factors. The purpose of this study was to clarify the factors that affect the 6MWT results in hemodialysis patients to assess their exercise tolerance. The study included 43 outpatients from the hemodialysis unit. The 6MWT was performed, and knee extension strength, 1‐leg standing time, and grip were measure...
Source: Therapeutic Apheresis and Dialysis - March 27, 2014 Category: Hematology Authors: Kenichi Kono, Yusuke Nishida, Yoshihumi Moriyama, Hiroki Yabe, Masahiro Taoka, Takashi Sato Tags: Original Article Source Type: research

Statins side effects are minimal, study argues
ConclusionThis meta-analysis pooled results from 29 studies and has shown a very small increased risk of newly diagnosed diabetes mellitus. This is the same as the decreased risk of any cause of death in people taking statins, compared to placebo, to prevent a heart attack or stroke.The researchers point out some limitations to the meta-analysis: Each study did not report on all of the side effects, meaning that for each category of side effect, the number of participants differed. The side effect categories were only included if at least 500 people had reported suffering from it. This means there may be numerous other si...
Source: NHS News Feed - March 13, 2014 Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news