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Comparison between Single and Three Times Pre-operative Administration of Amoxicillin in the Prophylactic Effects for Surgical Site Infections in Japanese Patients with Mandibular Third Molars Extraction
Yakugaku Zasshi. 2022;142(12):1391-1398. doi: 10.1248/yakushi.22-00163.ABSTRACTAlthough the dosage of oral antibiotics (OA) for the mandibular third molar extraction (MTME) varies among the administration periods according to the current guideline, our previous reports suggested that it might be possible to further shorten the administration period without increasing the incidence of surgical site infection (SSI). In the present study, we retrospectively evaluated the relationship between the incidence of SSI and the administration period of OA in patients who underwent the MTME in our hospital. This retrospective cohort s...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 30, 2022 Category: Drugs & Pharmacology Authors: Kensuke Yoshida Yasumitsu Kodama Chie Saito Kei Tomihara Akira Toyama Source Type: research

Sustained release of curcumin from fibrin matrix induces cancer cell death and immunomodulation.
This study describes the advantages of clinical-grade curcumin-incorporated fibrin matrix either in lyophilized off-the-shelf wafer or injectable hydrogel forms, as a biodegradable local delivery system. To produce the curcumin-fibrin wafer, used clinical-grade fibrin sealant in a modified composition. To fabricate wafer, we premixed the curcumin with either fibrinogen or thrombin, before clotting into a hydrogel. Sustained release of active curcumin from fibrin wafer, suspended in culture medium at 37 °C lasted for seven days. Upon premixing albumin with thrombin and subsequently adding curcumin into the mixture improved...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 19, 2020 Category: Drugs & Pharmacology Authors: Aravind SR, Lakshmi S, S R, Krishnan LK Tags: Biomed Pharmacother Source Type: research

Zeolite-based hemostat QuikClot releases calcium into blood and promotes blood coagulation in vitro.
Conclusion:Zeolite releases Ca(2+) into blood, thus accelerating the intrinsic pathway of blood coagulation and shortening the clot formation time. PMID: 23334236 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - January 21, 2013 Category: Drugs & Pharmacology Authors: Li J, Cao W, Lv XX, Jiang L, Li YJ, Li WZ, Chen SZ, Li XY Tags: Acta Pharmacol Sin Source Type: research