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Vaccination: Veterinary Vaccinations
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Total 1050 results found since Jan 2013.
Animal models and SARS-CoV-2-induced pulmonary and neurological injuries
Mem Inst Oswaldo Cruz. 2023 Jan 20;117:e220239. doi: 10.1590/0074-02760220239. eCollection 2023.ABSTRACTLaboratory animals are essential mainly for experiments aiming to study pathogenesis and evaluate antivirals and vaccines against emerging human infectious diseases. Preclinical studies of coronavirus disease 19 (COVID-19) pathogenesis have used several animal species as models: transgenic human ACE2 mice (K18 mice), inbred BALB/c or C57BL/6N mice, ferrets, minks, domestic cats and dogs, hamsters, and macaques. However, the choice of an animal model relies on several limitations. Besides the host susceptibility, the rese...
Source: Memorias do Instituto Oswaldo Cruz - January 26, 2023 Category: Infectious Diseases Authors: Marcelo Alves Pinto Alexandre Dos Santos da Silva Daniela Del Rosario Flores Rodrigues Rodrigo M üller Gentil Arthur Lins Bentes Mendon ça de Vasconcelos Patr ícia Cristina da Costa Neves Jaqueline Mendes de Oliveira Renato Sergio Marchevsky Source Type: research
Data Doesn ’t Support New COVID-19 Booster Shots for Most, Says Vaccine Expert
In a perspective published Jan. 11 in the New England Journal of Medicine, vaccine expert Dr. Paul Offit says it’s time to rethink booster recommendations.
In the third year of the pandemic, the population’s immune situation is vastly different from what it was in 2019 when SARS-CoV-2 emerged. Now, most people have been vaccinated against the virus, been infected with it (once or multiple times), or both. And the latest data show that the newest booster shot, which targets the Omicron BA.4/5 strain and original virus variants in a bivalent formulation, isn’t that much more effective in generating virus-fi...
Source: TIME: Health - January 11, 2023 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news
A comprehensive molecular survey of viral pathogens associated with canine gastroenteritis
This study highlights the need for routine prophylactic vaccination with the appropriate vaccines. Notably, 70.3% of animals vaccinated with DHPPiL were found to be positive for at least one virus. Hence, regular molecular analysis of t he prevalent viruses is crucial for addressing vaccination failures.
Source: Archives of Virology - January 7, 2023 Category: Virology Source Type: research
Porcine Epidemic Diarrhea Virus nsp13 Protein Downregulates Neonatal Fc Receptor Expression by Causing Promoter Hypermethylation through the NF- κB Signaling Pathway
In this study, we showed for the first time, to our knowledge, that FcRn expression can be influenced by methyltransferases. In addition, we found that PEDV inhibited FcRn protein synthesis in porcine small intestinal epithelial cells postinfection. Then, we found that PEDV interfered with the transcription of genes through aberrant methylation modification of the FcRn promoter. DNA methyltransferase 3b (DNMT3b) has been implicated in this process. Using a series of PEDV structural and nonstructural protein (nsp) expression plasmids, we showed that nsp13 plays an important role in this aberrant methylation modification. PE...
Source: Journal of Immunology - January 5, 2023 Category: Allergy & Immunology Authors: Xiangchao Jia Jing Chen Chenyuan Qiao Chenxi Li Kang Yang Yang Zhang Jian Li Zili Li Source Type: research
