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Vaccination: Veterinary Vaccinations
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Total 1050 results found since Jan 2013.
Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based SARS-CoV-2 RBD vaccine formulated with 3M-052-Alum adjuvant
In this study, we report a preclinical evaluation of the immunogenicity, efficacy and safety of a recombinant plant-based SARS-CoV-2 RBD vaccine formulated with 3M-052 (TLR7/8 agonist)-Alum adjuvant. This vaccine formulation, named Baiya SARS-CoV-2 Vax 2, induced significant levels of RBD-specific IgG and neutralizing antibody responses in mice. A viral challenge study using humanized K18-hACE2 mice has shown that animals vaccinated with two doses of Baiya SARS-CoV-2 Vax 2 established immune protection against SARS-CoV-2. A study in nonhuman primates (cynomolgus monkeys) indicated that immunization with two doses of Baiya ...
Source: Vaccine - March 24, 2023 Category: Allergy & Immunology Authors: Waranyoo Phoolcharoen Balamurugan Shanmugaraj Narach Khorattanakulchai Piyanate Sunyakumthorn Sathit Pichyangkul Pornnarin Taepavarapruk Wanlapa Praserthsee Suchinda Malaivijitnond Suwimon Manopwisedjaroen Arunee Thitithanyanont Kanjana Srisutthisamphan A Source Type: research
miRNAs derived from milk small extracellular vesicles inhibit porcine epidemic diarrhea virus infection
This study is the first description of the novel function of porcine milk sEV in regulating PEDV infection. It provides a better understanding of milk sEV resistance to coronavirus infection, warranting further studies to develop sEV as an attractive antiviral.PMID:36907442 | DOI:10.1016/j.antiviral.2023.105579
Source: Antiviral Research - March 12, 2023 Category: Virology Authors: Jia Qi Liang Mei-Ying Xie Lianjie Hou Hai-Long Wang Jun-Yi Luo Jia-Jie Sun Qian-Yun Xi Qing-Yan Jiang Ting Chen Yong-Liang Zhang Source Type: research
Viruses, Vol. 15, Pages 725: Use of a Preclinical Natural Transmission Model to Study Antiviral Effects of a Carbohydrate-Binding Module Therapy against SARS-CoV-2 in Hamsters
This study demonstrates that using a combination of a prophylactic and therapeutic delivery of Neumifil significantly reduces the severity of clinical signs in animals infected via a natural route of transmission and indicates a reduction of viral loads in the upper respiratory tract. Further refinements of the model are required in order to ensure the adequate transmission of the virus. However, our results provide additional data to the evidence base of Neumifil efficacy against respiratory virus infection and demonstrate that the transmission model is a potentially valuable tool for testing antiviral compounds against SARS-CoV-2.
Source: Viruses - March 11, 2023 Category: Virology Authors: Daniel Knott Rachel Fell Jane A. Potter Samantha Yuille Franscisco J. Salguero Victoria A. Graham Roger Hewson David Howat Stuart D. Dowall Tags: Communication Source Type: research
Heterologous boost with mRNA vaccines against SARS-CoV-2 Delta/Omicron variants following an inactivated whole-virus vaccine
This study characterizes two mRNA vaccines ZSVG-02 (Delta) and ZSVG-02-O (Omicron BA.1), and associating heterologous prime-boost strategy following the prime of a most widely administrated inactivated whole-virus vaccine (BBIBP-CorV). The ZSVG-02-O induces neutralizing antibodies that effectively cross-react with Omicron subvariants. In naïve animals, ZSVG-02 or ZSVG-02-O induce humoral responses skewed to the vaccine's targeting strains, but cellular immune responses cross-react to all variants of concern (VOCs) tested. Following heterologous prime-boost regimes, animals present comparable neutralizing antibody levels a...
Source: Antiviral Research - March 5, 2023 Category: Virology Authors: Changrui Lu Yuntao Zhang Xiaohu Liu Fujun Hou Rujie Cai Zhibin Yu Fei Liu Guohuan Yang Jun Ding Jiang Xu Xianwu Hua Xinhua Cheng Xinping Pan Lianxiao Liu Kang Lin Zejun Wang Xinguo Li Jia Lu Qiu Zhang Yuwei Li Chunxia Hu Huifen Fan Xiaoke Liu Hui Wang Rui Source Type: research
A research and development (R & amp;D) roadmap for broadly protective coronavirus vaccines: A pandemic preparedness strategy
This report summarizes the major issues and areas of research outlined in the CVR and identifies high-priority milestones. The CVR covers a 6-year timeframe and is organized into five topic areas: virology, immunology, vaccinology, animal and human infection models, and policy and finance. Included in each topic area are key barriers, gaps, strategic goals, milestones, and additional R&D priorities. The roadmap includes 20 goals and 86 R&D milestones, 26 of which are ranked as high priority. By identifying key issues, and milestones for addressing them, the CVR provides a framework to guide funding and research cam...
Source: Vaccine - March 4, 2023 Category: Allergy & Immunology Authors: Kristine A Moore Tabitha Leighton Julia T Ostrowsky Cory J Anderson Richard N Danila Angela K Ulrich Eve M Lackritz Angela J Mehr Ralph S Baric Norman W Baylor Bruce G Gellin Jennifer L Gordon Florian Krammer Stanley Perlman Helen V Rees Melanie Saville C Source Type: research
