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Molecular surveillance of potential SARS-CoV-2 reservoir hosts in wildlife rehabilitation centers
Vet Q. 2023 Jan 3:1-17. doi: 10.1080/01652176.2023.2164909. Online ahead of print.ABSTRACTBACKGROUND: The COVID-19 pandemic, caused by SARS-CoV-2 infection, has become the most devastating zoonotic event in recent times, with negative impacts on both human and animal welfare as well as on the global economy. Although SARS-CoV-2 is considered a human virus, it likely emerged from animals, and it can infect both domestic and wild animals. This constitutes a risk for human and animal health including wildlife with evidence of SARS-CoV-2 horizontal transmission back and forth between humans and wild animals.AIM: Molecular surv...
Source: Veterinary Quarterly - January 3, 2023 Category: Veterinary Research Authors: Juan Mena Christian Hidalgo Daniela Estay-Olea Nicole Sallaberry-Pincheira Antonella Bacigalupo Andr é V Rubio Diego Pe ñaloza Carolina S ánchez Javiera G ómez-Adaros Valeria Olmos Javier Cabello Kendra Ivelic Mar ía José Abarca Diego Ram írez-Álv Source Type: research
Applications of Nanobodies in the Prevention, Detection, and Treatment of the Evolving SARS-CoV-2
Biochem Pharmacol. 2022 Dec 30:115401. doi: 10.1016/j.bcp.2022.115401. Online ahead of print.ABSTRACTGlobal health and economy are deeply influenced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its newly emerging variants. Nanobodies with nanometer-scale size are promising for the detection and treatment of SARS-CoV-2 and its variants because they are superior to conventional antibodies in terms of cryptic epitope accessibility, tissue penetration, cost, formatting adaptability, and especially protein stability, which enables their aerosolized specific delivery to lung tissues. This review summar...
Source: Biochemical Pharmacology - January 2, 2023 Category: Drugs & Pharmacology Authors: Wenyi Wang Yue Hu Bohan Li Huanan Wang Jinhua Shen Source Type: research
Xi Jinping opens up on zero COVID reversal: ' It has not been an easy journey for anyone '
President Xi Jinping said China has entered a new phase in its fight against the coronavirus and tough challenges remain, his most frank public comments on the reversal of the Covid Zero policy that’s resulted in nationwide outbreaks and tested the health system and economy. “Following a…#pelosis #newyears #communistparty #taipei #haitongsecuritiesco #indonesia #newyear #macau #covidzero #shanghai
Source: Reuters: Health - January 1, 2023 Category: Consumer Health News Source Type: news
Amid the climate crisis, Covid and crumbling democracies, I find hope in people who show the best of humanity | Trent Zimmerman
It ’s the potential of individuals to change the world which is at the heart of democratic liberalism – but their actions must be matched by global supportAs we farewell 2022, many of the world ’s citizens will be hoping for a better new year. It is hard to look back on the past year – indeed couple of years – without a high degree of angst about the direction of our global community.We have been battered by a pandemic that, while past the peak for most nations, is still disrupting societies and economies. After two years of its hermit-like isolation, 1.4 billion Chinese citizens are now experiencing a nationwide...
Source: Guardian Unlimited Science - December 30, 2022 Category: Science Authors: Trent Zimmerman Tags: World news Coronavirus Science Protest Activism Iran Afghanistan Australia news China Climate crisis Asia Pacific Environment Source Type: news
White House confident about economic recovery in 2023
WASHINGTON — Despite the ongoing turbulence caused by the coronavirus pandemic and the shock of war in Eastern Europe, the American economy is in sound health, top Biden administration economist Jared Bernstein asserted in an end-of-year interview with Yahoo News. The upcoming year may not be one…#minnesota #easterneurope #justinwolfers #yahoonews #renaissancemacro #universityofmichigan #neildutta #danielbachman #danielswan #bachman
Source: Reuters: Health - December 29, 2022 Category: Consumer Health News Source Type: news
Advanced Plasmonic Nanoparticle-Based Techniques for the Prevention, Detection, and Treatment of Current COVID-19
AbstractCoronavirus is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2. Coronavirus disease 2019 known as COVID-19 is the worst pandemic since World War II. The outbreak of COVID-19 had a significant repercussion on the health, economy, politics, and environment, making coronavirus-related issues more complicated and becoming one of the most challenging pandemics of the last century with deadly outcomes and a high rate of the reproduction number. There are thousands of different types — or variants — of COVID circulating across the world. Viruses mutate all the time; it emphasizes t...
Source: Plasmonics - December 23, 2022 Category: Biomedical Science Source Type: research
Emerging toolset of three-dimensional pulmonary cell culture models for simulating lung pathophysiology towards mechanistic elucidation and therapeutic treatment of SARS-COV-2 infection
The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a never before seen challenge to human health and the world economy. However, it is difficult to widely use conventional animal and cell culture models in understanding the underlying pathological mechanisms of COVID-19, which in turn hinders the development of relevant therapeutic treatments, including drugs. To overcome this challenge, various three-dimensional (3D) pulmonary cell culture models such as organoids are emerging as an innovative toolset for simulating the pathophysiology occurring in the respiratory sy...
Source: Frontiers in Pharmacology - December 12, 2022 Category: Drugs & Pharmacology Source Type: research
Chinese Stocks Soar to 3-Month High as Covid Measures Relaxed, Global Markets Follow
Chinese stocks soared to a 3-month high after authorities alleviated coronavirus restrictions in major cities and 10 other provincial capitals, boosting the investors’ confidence in the world’s second-largest economy. The benchmark Hang Seng Index jumped 2.3%, while the capitalization-weighted CSI…#hangsengindex #hycm #hongkong #tickhigher #measuresstocks #mscis #sp #federalreserves #ukftse #smartasset
Source: Reuters: Health - December 10, 2022 Category: Consumer Health News Source Type: news
Nucleic acid testing of SARS-CoV-2: A review of current methods, challenges, and prospects
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has brought a huge threat to public health and the global economy. Rapid identification and isolation of SARS-CoV-2-infected individuals are regarded as one of the most effective measures to control the pandemic. Because of its high sensitivity and specificity, nucleic acid testing has become the major method of SARS-CoV-2 detection. A deep understanding of different diagnosis methods for COVID-19 could help researchers make an optimal choice in detecting COVID-19 at different symptom stages. In this review, we...
Source: Frontiers in Microbiology - December 9, 2022 Category: Microbiology Source Type: research
Drug repositioning for SARS-CoV-2 by Gaussian kernel similarity bilinear matrix factorization
In this study, we collected known antiviral drugs to form five virus-drug association datasets, and then explored drug repositioning for SARS-CoV-2 by Gaussian kernel similarity bilinear matrix factorization (VDA-GKSBMF). By the 5-fold cross-validation, we found that VDA-GKSBMF has an area under curve (AUC) value of 0.8851, 0.8594, 0.8807, 0.8824, and 0.8804, respectively, on the five datasets, which are higher than those of other state-of-art algorithms in four datasets. Based on known virus-drug association data, we used VDA-GKSBMF to prioritize the top-k candidate antiviral drugs that are most likely to be effective aga...
Source: Frontiers in Microbiology - December 5, 2022 Category: Microbiology Source Type: research
China ’s Zero-COVID Trap
Protesters in China have demanded an end to the country’s draconian zero-COVID policy—a pandemic prevention strategy that President Xi Jinping claims has kept his people safer than less stringent measures taken by other nations—as the suffering it’s wrought is becoming increasingly unbearable.
Experts have said it’s unlikely the government will outright end zero-COVID anytime soon, though it may continue to tweak the policy. But even if Xi wanted to ditch the strategy altogether, as some localities are reportedly starting to do, that could bring about even more misery.
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Source: TIME: Health - December 1, 2022 Category: Consumer Health News Authors: Chad de Guzman and Amy Gunia Tags: Uncategorized China COVID-19 overnight Source Type: news
