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Results of surgical therapy of functioning pituitary adenomas
CONCLUSION: Surgical therapy in the presented cohort led to the normalisation of hormonal excessive production in 58.6% of cases. A combination of drug therapy and radiotherapeutic methods was necessary in the remaining cases to achieve hormonal remission.PMID:37737300 | DOI:10.5507/bp.2023.037
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 22, 2023 Category: Biomedical Science Authors: Vlastimil Novak Lumir Hrabalek Jan Schovanek Zdenek Frysak Racheal Temitope Ijisesan Perryova Daniel Pohlodek Source Type: research
Effect of a psycho-awareness-training program on women's attitude and psychosomatic status post-abortion in Jazan, Saudi Arabia
This study aimed to assess the effect of a psycho-awareness-training program on women's knowledge and psychosomatic status post-abortion in Jazan, Saudi Arabia. a one-group pre- and post-test quasi-experimental design was conducted among 135 eligible women post-abortion. Researchers used an Arabic questionnaire online survey containing items on women's characteristics, knowledge of abortion, and psychosomatic status post-abortion. The majority of the participants were married (95.6%) and had a university degree (58.5%). The total satisfactory knowledge increased significantly from 29.6% at baseline to 91% post-training (p ...
Source: African Journal of Reproductive Health - September 22, 2023 Category: African Health Authors: Hassani Rym Fadlalmola Hammad Said Thanaa AlZahrani Badria Mariod Abdalbasit Source Type: research
Determinants of the unmet needs for information, education and communication on sexual health among single youths in Burundi
Afr J Reprod Health. 2023 Aug 31;27(8):39-37. doi: 10.29063/ajrh2023/v27i8.5.ABSTRACTThe prevalence of HIV/AIDS among young people aged 15-24 in urban areas is at least 12 times higher among girls than boys in Burundi, while it is twice as high in Rwanda. The gap between the two countries could be narrowed if Burundi's single young people were provided with sufficient information about their sexual health through appropriate channels. The aim of this study was to examine the social and individual "determinants" of unmet needs for sexual health information, education and communication (IEC) among unmarried young boys and gi...
Source: African Journal of Reproductive Health - September 22, 2023 Category: African Health Authors: Bahimana Adolphe Mburano Rwenge Jean-Robert Source Type: research
Hwiccewyrm trispiculum gen. et sp. nov., a new leptopleuronine procolophonid from the Late Triassic of southwest England
Anat Rec (Hoboken). 2023 Sep 21. doi: 10.1002/ar.25316. Online ahead of print.ABSTRACTThe fissure fill localities of southwest England and South Wales are well-known for preserving rich assemblages of predominantly small-bodied Late Triassic to Early Jurassic tetrapods, but many aspects of these assemblages remain contentious. The age of the Late Triassic fissures is disputed, with some lines of argument suggesting a latest Triassic (Rhaetian) age, whereas other evidence suggests they may be as old as Carnian. The fissures have been hypothesized by some workers to have formed on an archipelago, with island effects invoked ...
Source: Anatomical Record - September 22, 2023 Category: Anatomy Authors: Richard J Butler Luke E Meade Terri J Cleary Kai T McWhirter Emily E Brown Tom S Kemp Juan Benito Nicholas C Fraser Source Type: research
Telehealth as an Effective Care Delivery Method During the COVID-19 Pandemic for the Rhode Island Behavioral Health Population
This study investigated (1) if telehealth allowed for patients who seek mental health services to maintain visit frequency and (2) if subpopulations were less likely to utilize telehealth. We used descriptive statistics to analyze the change in total number of visits, in-person visits from pre-waiver to post-waiver, and a multivariate linear regression to identify relationships between demographics and telehealth utilization. Participants were able to maintain the frequency of visits during the COVID-19 pandemic. Race/ethnicity, age, gender, employment status, and housing status were all statistically significant predictor...
Source: Community Mental Health Journal - September 22, 2023 Category: Psychiatry Authors: Demetria Flowers Emily Goodspeed Mackenzie Daly Source Type: research
Epigenetic reprogramming of a distal developmental enhancer cluster drives SOX2 overexpression in breast and lung adenocarcinoma
Nucleic Acids Res. 2023 Sep 22:gkad734. doi: 10.1093/nar/gkad734. Online ahead of print.ABSTRACTEnhancer reprogramming has been proposed as a key source of transcriptional dysregulation during tumorigenesis, but the molecular mechanisms underlying this process remain unclear. Here, we identify an enhancer cluster required for normal development that is aberrantly activated in breast and lung adenocarcinoma. Deletion of the SRR124-134 cluster disrupts expression of the SOX2 oncogene, dysregulates genome-wide transcription and chromatin accessibility and reduces the ability of cancer cells to form colonies in vitro. Analysis...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Luis E Abatti Patricia Lado-Fern ández Linh Huynh Manuel Collado Michael M Hoffman Jennifer A Mitchell Source Type: research
Fructose-induced mTORC1 Activation Promotes Pancreatic Cancer Progression through Inhibition of Autophagy
In this study, we investigated the functional association between fructose utilization and pancreatic ductal adenocarcinoma (PDAC) progression. Fructose could be taken up and metabolized by PDAC cells and provided an adaptive survival mechanism for PDAC cells under glucose deficient conditions. GLUT5-mediated fructose metabolism maintained the survival, proliferation, and invasion capacities of PDAC cells in vivo and in vitro. Fructose metabolism not only provided ATP and biomass to PDAC cells but also conferred metabolic plasticity to the cells, making them more adaptable to the tumor microenvironment. Mechanistically, fr...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Yanfen Cui Jianfei Tian Zhaosong Wang Hui Guo He Zhang Zhiyong Wang Hui Liu Weijie Song Liming Liu Ruinan Tian Xiaoyan Zuo Sixin Ren Ruifang Niu Fei Zhang Source Type: research
Galectin-3 Cooperates with CD47 to Suppress Phagocytosis and T cell Immunity in Gastric Cancer Peritoneal Metastases
Cancer Res. 2023 Sep 22. doi: 10.1158/0008-5472.CAN-23-0783. Online ahead of print.ABSTRACTThe peritoneal cavity is a common site of gastric adenocarcinoma (GAC) metastasis. Peritoneal carcinomatosis (PC) is resistant to current therapies and confer poor prognosis, highlighting the need to identify new therapeutic targets. CD47 conveys a "don't eat me" signal to myeloid cells upon binding its receptor SIRPα, which helps tumor cells circumvent macrophage phagocytosis and evade innate immune responses. Previous studies demonstrated that the blockade of CD47 alone results in limited clinical benefits, suggesting that other t...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Yibo Fan Shumei Song Yuan Li Shilpa S Dhar Jiankang Jin Katsuhiro Yoshimura Xiaodan Yao Ruiping Wang Ailing W Scott Melissa Pool Pizzi JingJing Wu Lang Ma George A Calin Samir Hanash Linghua Wang Michael Curran Jaffer A Ajani Source Type: research
The combination of PAC-1 and entrectinib for the treatment of metastatic uveal melanoma
This study is an initial demonstration that the combination of PAC-1 and entrectinib may warrant further clinical investigation. Clinical trial registration: Clinical Trials.gov: NCT04589832.PMID:37738028 | DOI:10.1097/CMR.0000000000000927
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Matthew W Boudreau Emily J Tonogai Claire P Schane Min X Xi James H Fischer Jayanthi Vijayakumar Yan Ji Theodore M Tarasow Timothy M Fan Paul J Hergenrother Arkadiusz Z Dudek Source Type: research
Effect of lactic acid bacteria by different concentrations of copper based on non-target metabolomic analysis
In this study, a strain of lactic acid bacteria (LAB), namely, Lactiplantibacillus plantarum CICC 23121 (L23121), was selected as a prebiotic indicator strain to indirectly assess the effects of food-limited Cu (II) concentrations (issued by Tolerance limit of copper in foods in 1994) on the functions of intestinal microbes. We used non-target metabolomics, automatic growth curve detector, scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR) to investigate the effects of Cu (II) on L23121. The study revealed shows that the 50% minimum inhibitory concentration (MIC50) of Cu (II) for most la...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Xinlei Li Shiyue Chen Lili Zhao Xiangpeng Zeng Yanyan Liu Chaochuang Li Qingxiang Yang Source Type: research
Harnessing Dendritic Cells: Next Frontier for Durable Immune Control in Myeloma
Clin Cancer Res. 2023 Sep 22:OF1-OF3. doi: 10.1158/1078-0432.CCR-23-2292. Online ahead of print.ABSTRACTImmune-based approaches including T-cell redirection have transformed the therapeutic landscape in myeloma. Injection of dendritic cells (DC) led to the induction of immune responses in vaccinated patients with myeloma. These studies pave the way for future combination strategies harnessing DCs to enhance tumor immunity and improve outcomes in myeloma. See related article by Freeman et al., p. 000.PMID:37737650 | DOI:10.1158/1078-0432.CCR-23-2292
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Madhav V Dhodapkar Source Type: research
MAPK Signaling Pathway Plays Different Regulatory Roles in the Effects of Boric Acid on Proliferation, Apoptosis, and Immune Function of Splenic Lymphocytes in Rats
In this study, ERK1/2, JNK, and p38MAPK signaling pathways were blocked using specific blockers to investigate the impact of low-dose and high-dose boron on proliferation, apoptosis, and immune function of lymphocytes, and the expression of genes related to cell proliferation and apoptosis in rats. The addition of 0.4 mmol/L boron did not affect the ratio of CD4+/CD8+ T cells (P>0.05), IgG and IFN-γ contents (P>0.05), the proliferation rate of lymphocytes (P>0.05), and mRNA and protein expressions of PCNA (P>0.05) in the spleen after ERK1/2 signal pathway was selectively inhibited. Moreover, the addition of 40...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Shuqin Chen Haoran Fan Yaqiong Pei Kaihuan Zhang Feng Zhang Qianqian Hu Erhui Jin Shenghe Li Source Type: research
Role of telitacicept in the treatment of IgA nephropathy
This article reviews the role of telitacicept in IgA nephropathy and discusses its potential for use in the treatment of IgAN and other autoimmune diseases where pathogenesis is driven by B cells.PMID:37737205 | DOI:10.1186/s40001-023-01320-2
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Lijun Wu Xinru Du Xuehong Lu Source Type: research
Circ_0000396 suppresses the proliferation and inflammation of rheumatoid arthritis synovial fibroblasts by targeting miR-574-5p/RSPO1 axis
CONCLUSION: Circ_0000396 restrained the proliferation and inflammation and induced the apoptosis of RASFs by mediating miR-574-5p/RSPO1 axis, which provided novel potential targets for RA treatment.PMID:37737195 | DOI:10.1186/s13018-023-04117-5
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Hongchao Yu Jin Yang Kun Chen Wulin Kang Fengfeng Zhu Source Type: research
PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
CONCLUSIONS: Patients with AF exhibit increased levels of PPP1R12C protein compared with controls. PPP1R12C overexpression in mice increases PP1c targeting to MLC2a and causes MLC2a dephosphorylation, which reduces atrial contractility and increases AF inducibility. These findings suggest that PP1 regulation of sarcomere function at MLC2a is a key determinant of atrial contractility in AF.PMID:37737016 | DOI:10.1161/CIRCRESAHA.123.322516
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Srikanth Perike Francisco J Gonzalez-Gonzalez Issam Abu-Taha Frederick W Damen Laurin M Hanft Ken S Lizama Anahita Aboonabi Andrielle E Capote Yuriana Aguilar-Sanchez Benjamin Levin Zhenbo Han Arvind Sridhar Jacob Grand Jody Martin Joseph G Akar Chad M Wa Source Type: research
