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Infectious Disease: Parasitic Diseases
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Total 32128 results found since Jan 2013.
Evaluating the Genetic Capacity of Mycoplasmas for Coenzyme A Biosynthesis in a Search for New Anti-mycoplasma Targets
Mycoplasmas are responsible for a wide range of disease states in both humans and animals, in which their parasitic lifestyle has allowed them to reduce their genome sizes and curtail their biosynthetic capabilities. The subsequent dependence on their host offers a unique opportunity to explore pathways for obtaining and producing cofactors – such as coenzyme A (CoA) – as possible targets for the development of new anti-mycoplasma agents. CoA plays an essential role in energy and fatty acid metabolism and is required for membrane synthesis. However, our current lack of knowledge of the relevance and importance of the C...
Source: Frontiers in Microbiology - December 20, 2021 Category: Microbiology Source Type: research
Delusional parasitosis: an entomological perspective after a 20-years-experience in two public medical and veterinary entomology laboratories
Acta Trop. 2022 Jul 21:106614. doi: 10.1016/j.actatropica.2022.106614. Online ahead of print.ABSTRACTDelusional parasitosis (DP) is psychiatric disorder characterized by the unshakeable belief of being infested by endo- or ectoparasites, without any evidence of infestations. Hence, DP sufferers often consult medical entomologists or dermatologists, rather than seeking help from a mental health practitioner. Here we present 39 cases of suspected DP occurred in twenty years in two Italian public medical entomology laboratories, to highlight their common features and peculiarities, based on the interviews and material brought...
Source: Acta Tropica - July 25, 2022 Category: Infectious Diseases Authors: Federico Romiti Adele Magliano Irene Del Lesto Lorena Filugelli Fabrizio Montarsi Sara Carlin Claudio De Liberato Source Type: research
A Quinquennial Review on Recent Advancements and Developments in Search of Anti- malarial Agents
Curr Top Med Chem. 2023 Apr 27. doi: 10.2174/1568026623666230427115241. Online ahead of print.ABSTRACTMalaria has been a major parasitic disease in tropical and subtropical regions and is estimated to kill between one and two million people (mainly children) every year. Novel anti-malarial agents are urgently needed to combat the malarial parasites enduring resistance to the current medications, leading to increased morbidity and mortality. The heterocycles, holding a prominent position in chemistry and found in both natural and synthetic sources, have shown several biological activities including anti-malarial activity. T...
Source: Current Topics in Medicinal Chemistry - April 27, 2023 Category: Chemistry Authors: Tejas M Dhameliya Deepika Kathuria Tanvi M Patel Bhavarth P Dave Amit Z Chaudhari Drashtiben D Vekariya Source Type: research
An ordinary malaria? Intermittent fever in Denmark, 1826-1886
This article studies the development in how intermittent fever was framed in Denmark between 1826 and 1886 through terminology, clinical symptoms and aetiology. In the 1820s and 1830s, intermittent fever was a broad disease category, which the diagnosis 'koldfeber'. Danish physicians were inspired by Hippocratic teachings in the early nineteenth century, and patients were seen as having unique constitutions. For that reason, intermittent fevers presented itself as both benign and severe with a broad spectrum of clinical symptoms. As the Parisian school gradually replaced humoral pathology in the mid-nineteenth century, int...
Source: Medical History - July 18, 2023 Category: History of Medicine Authors: Mathias M ølbak Ingholt Source Type: research
