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Infectious Disease: Hepatitis C
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Differential expression of "A Disintegrin and Metalloproteinase 10" in hepatocellular carcinoma and the noncancerous hepatic tissues: Contribution to HCV-promoted hepatocarcinogenesis
CONCLUSIONS: ADAM10 is frequently expressed in HCCs compared with noncancerous hepatic tissues suggesting its role in hepatocarcinogenesis, especially in association with HCV. It has no association with HCC progression or survival. Further studies should be sought to investigate its validity as a therapeutic target.PMID:37530332 | DOI:10.4103/ijpm.ijpm_608_21
Source: Indian Journal of Pathology and Microbiology - August 2, 2023 Category: Pathology Authors: Amal Abd El Hafez Basem H Elesawy Heba S E I Hany Source Type: research
Identification of an Oligostilbene, Vaticanol B, from Dryobalanops aromatica Leaves as an Antiviral Compound against the Hepatitis C Virus
Biol Pharm Bull. 2023;46(8):1079-1087. doi: 10.1248/bpb.b23-00086.ABSTRACTChronic hepatitis C virus (HCV) infection can lead to liver cirrhosis and hepatocellular carcinoma. Although current medications using direct-acting antivirals (DAAs) are highly effective and well-tolerated for treating patients with chronic HCV, high prices and the existence of DAA-resistant variants hamper treatment. There is thus a need for easily accessible antivirals with different mechanisms of action. During the screening of Indonesian medicinal plants for anti-HCV activity, we found that a crude extract of Dryobalanops aromatica leaves posses...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Chie Aoki-Utsubo Muhammad Hanafi Destia Tri Armanti Hiroyuki Fuchino Nobuo Kawahara Sri Hartati Aty Widyawaruyanti Pratiwi Sudarmono Masanori Kameoka Hak Hotta Source Type: research
Differential expression of "A Disintegrin and Metalloproteinase 10" in hepatocellular carcinoma and the noncancerous hepatic tissues: Contribution to HCV-promoted hepatocarcinogenesis
CONCLUSIONS: ADAM10 is frequently expressed in HCCs compared with noncancerous hepatic tissues suggesting its role in hepatocarcinogenesis, especially in association with HCV. It has no association with HCC progression or survival. Further studies should be sought to investigate its validity as a therapeutic target.PMID:37530332 | DOI:10.4103/ijpm.ijpm_608_21
Source: Indian Journal of Pathology and Microbiology - August 2, 2023 Category: Pathology Authors: Amal Abd El Hafez Basem H Elesawy Heba S E I Hany Source Type: research
Identification of an Oligostilbene, Vaticanol B, from Dryobalanops aromatica Leaves as an Antiviral Compound against the Hepatitis C Virus
Biol Pharm Bull. 2023;46(8):1079-1087. doi: 10.1248/bpb.b23-00086.ABSTRACTChronic hepatitis C virus (HCV) infection can lead to liver cirrhosis and hepatocellular carcinoma. Although current medications using direct-acting antivirals (DAAs) are highly effective and well-tolerated for treating patients with chronic HCV, high prices and the existence of DAA-resistant variants hamper treatment. There is thus a need for easily accessible antivirals with different mechanisms of action. During the screening of Indonesian medicinal plants for anti-HCV activity, we found that a crude extract of Dryobalanops aromatica leaves posses...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Chie Aoki-Utsubo Muhammad Hanafi Destia Tri Armanti Hiroyuki Fuchino Nobuo Kawahara Sri Hartati Aty Widyawaruyanti Pratiwi Sudarmono Masanori Kameoka Hak Hotta Source Type: research
Differential expression of "A Disintegrin and Metalloproteinase 10" in hepatocellular carcinoma and the noncancerous hepatic tissues: Contribution to HCV-promoted hepatocarcinogenesis
CONCLUSIONS: ADAM10 is frequently expressed in HCCs compared with noncancerous hepatic tissues suggesting its role in hepatocarcinogenesis, especially in association with HCV. It has no association with HCC progression or survival. Further studies should be sought to investigate its validity as a therapeutic target.PMID:37530332 | DOI:10.4103/ijpm.ijpm_608_21
Source: Indian Journal of Pathology and Microbiology - August 2, 2023 Category: Pathology Authors: Amal Abd El Hafez Basem H Elesawy Heba S E I Hany Source Type: research
