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Therapy: Cancer Therapy
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Total 225 results found since Jan 2013.
Immunosuppressive Effects and Potent Anti-tumor Efficacy of mTOR Inhibitor Everolimus in Breast Tumor-bearing Mice
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):287-299. doi: 10.18502/ijaai.v21i3.9802.ABSTRACTTo investigate the effects of everolimus, a mechanistic/mammalian target of rapamycin (mTOR) inhibitor, on tumor growth and immune response in a mouse model of breast cancer. Human hormone receptor-positive (HR+)/human epidermal growth receptor 2-negative (HER2-) MC4-L2 cell line was used to establish a mouse model of breast cancer. The inhibitory effects of high (10 mg/kg) and low (5 mg/kg) doses of everolimus were investigated on tumor growth. Additionally, the frequency of CD4+Foxp3+ regulatory T cells (Tregs), CD8+Foxp3+ Tr...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Davoud Rostamzadeh Mohammad Reza Haghshenas Mahdi Samadi Zahra Mojtahedi Zohreh Babaloo Abbas Ghaderi Source Type: research
