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Therapy: Cancer Therapy
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Tumor Microenvironment Changing through Application of MicroRNA-34a Related Mesenchymal Stem Cells Conditioned Medium: Modulation of Breast Cancer Cells toward Non-aggressive Behavior
Iran J Allergy Asthma Immunol. 2021 Apr 17;20(2):221-232.ABSTRACTConditioned medium (CM) derived from mesenchymal stem cells (MSCs) contains bioactive molecules including microRNAs (miRs) that could be a potential tool for controlling cancer cells' behavior. Due to the properties of CM, this study assesses the effects of miR-34a related MSC-CM on tumor behavior through the evaluation of migration, invasion, apoptosis, and PDL1 expression in breast cancer cell lines. The miR-34a overexpression vector or scramble control was produced using lentiviral vectors, DNA cloning, and the transfection of the HEK-293T cell line. It wa...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 27, 2021 Category: Allergy & Immunology Authors: Katayoun Bahman Soufiani Ali Akbar Pourfathollah Mahin Nikougoftar Zarif Ehsan Arefian Source Type: research
