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Total 2303 results found since Jan 2013.

Allergy in Hong Kong: an unmet need in service provision and training.
Abstract Many children in Hong Kong have allergic diseases and epidemiological data support a rising trend. Only a minority of children will grow out of their allergic diseases, so the heavy clinical burden will persist into adulthood. In an otherwise high-quality health care landscape in Hong Kong, allergy services and training are a seriously unmet need. There is one allergy specialist for 1.5 million people, which is low not only compared with international figures, but also compared with most other specialties in Hong Kong. The ratio of paediatric and adult allergists per person is around 1:460 000 and 1:2.8 m...
Source: Hong Kong Med J - January 2, 2015 Category: Journals (General) Authors: Chan YT, Ho HK, Lai CK, Lau CS, Lau YL, Lee TH, Leung TF, Wong GW, Wu YY, for The Hong Kong Allergy Alliance Tags: Hong Kong Med J Source Type: research

Systematic review of pathways for the delivery of allergy services
Conclusions Demand for allergy services appears to have significantly outpaced supply. Primary and secondary care pathways in allergy seem inadequate leading to poor referral practices, delays in patient management and consequently poor outcomes. Improvement of services requires strong public and political engagement. There is a need for well-planned, prospective studies in this area and a few are currently underway. There is no evidence to suggest that any given pathway of service provision is better than another although data from a few long-term, prospective studies look very promising.
Source: BMJ Open - February 6, 2017 Category: Journals (General) Authors: Diwakar, L., Cummins, C., Lilford, R., Roberts, T. Tags: Open access, General practice / Family practice, Health policy, Immunology (including allergy) Research Source Type: research

Use of a penicillin allergy clinical decision rule to enable direct oral penicillin provocation: an international multicentre randomised control trial in an adult population (PALACE): study protocol
Introduction Penicillin allergies are highly prevalent in the healthcare setting and associated with the prescription of second-line inferior antibiotics. More than 85% of all penicillin allergy labels can be removed by skin testing and 96%–99% of low-risk penicillin allergy labels can be removed by direct oral challenge. An internally and externally validated clinical assessment tool for penicillin allergy, PEN-FAST, can identify a low-risk penicillin allergy without the need for skin testing; a score of less than 3 has a negative predictive value of 96.3% (95% CI, 94.1 to 97.8) for the presence of a penicillin alle...
Source: BMJ Open - August 8, 2022 Category: General Medicine Authors: Copaescu, A.-M., James, F., Vogrin, S., Rose, M., Chua, K., Holmes, N. E., Turner, N. A., Stone, C., Phillips, E., Trubiano, J. Tags: Open access, Immunology (including allergy) Source Type: research

Mixed-methods evaluation of a behavioural intervention package to identify and amend incorrect penicillin allergy records in UK general practice
Conclusions This study highlights the positive effects of the ALABAMA behavioural intervention for both patients and clinicians. Trial registration number NCT04108637; ISRCTN20579216; Pre-results.
Source: BMJ Open - June 3, 2022 Category: General Medicine Authors: Wanat, M., Santillo, M., Galal, U., Davoudianfar, M., Bongard, E., Savic, S., Savic, L., Porter, C., Fielding, J., Butler, C. C., Pavitt, S., Sandoe, J., Tonkin-Crine, S., On behalf of the ALABAMA team, Boards, Bongard, Butler, Davoudianfar, East, Fieldin Tags: Open access, Immunology (including allergy) Source Type: research

Sublingual and Patch Immunotherapy for Food Allergy.
This article reviews research advances for sublingual and patch immunotherapy for food allergy with a focus on peanut allergy. Published studies on sublingual immunotherapy (SLIT) and epicutaneous immunotherapy (EPIT) were summarized in this review. Sublingual and epicutaneous methods have emerged as alternatives to oral immunotherapy. SLIT studies have shown modest desensitization with a robust safety profile. EPIT studies have high adherence rates, an excellent safety profile, and potential for desensitization in children. Advances in food immunotherapy with SLIT and EPIT studies have shown promise as viable alternatives...
Source: The Medical Clinics of North America - November 27, 2019 Category: General Medicine Authors: Waldron J, Kim EH Tags: Immunol Allergy Clin North Am Source Type: research

Study protocol of a phase 2, dual-centre, randomised, controlled trial evaluating the effectiveness of probiotic and egg oral immunotherapy at inducing desensitisation or sustained unresponsiveness (remission) in participants with egg allergy compared with placebo (Probiotic Egg Allergen Oral Immunotherapy for Treatment of Egg Allergy: PEAT study)
This study has been approved by the Human Research Ethics Committees at the Royal Children’s Hospital (HREC 2019.082) and the National Healthcare Group Domain Specific Review Board (2019/00029). Results will be published in peer-reviewed journals and disseminated via presentations at international conferences. Trial registration number ACTRN12619000480189.
Source: BMJ Open - July 7, 2021 Category: General Medicine Authors: Loke, P., Chebar Lozinsky, A., Orsini, F., Wong, L. S.-Y., Leung, A. S.-Y., Tham, E. H., Lopata, A. L., Shek, L. P.-C., Tang, M. L., PEAT study team, Su, Robinson, Tey, Belousoff, Pitkin, Axelrad, Mitra, Chan, Yi, Ng Tags: Open access, Immunology (including allergy) Source Type: research

Study protocol for PREPARE: a phase II feasibility/safety randomised controlled trial on PeRiopErative Penicillin AlleRgy TEsting
Introduction Patient-reported antibiotic allergy labels (AALs) are common. These labels have been demonstrated to have a negative impact on use of appropriate antibiotics and patient-related health outcomes. These patients are more likely to receive suboptimal antibiotics, have increased rates of surgical site infections and are more likely to be colonised with multidrug-resistant organisms. Increasing recognition that antibiotic allergy forms a key part of good antimicrobial stewardship has led to calls for greater access to antibiotic allergy assessment. PREPARE is a pilot randomised controlled trial of beta-lactam aller...
Source: BMJ Open - February 24, 2023 Category: General Medicine Authors: De Luca, J. F., James, F., Vogrin, S., Chua, K., Fletcher, L., Nazareth, J., Guha, R., Hardidge, A., Douglas, N., Carruthers, J., Stewardson, A., Cheng, A. C., Johnson, D., Douglass, J., Peel, T., Trubiano, J. Tags: Open access, Immunology (including allergy) Source Type: research

Hymenoptera venom allergy: work disability and occupational impact of venom immunotherapy
Conclusions Hymenoptera venom allergy could determine work disability. Patients with Hymenoptera venom allergy having a high-risk job for exposure to Hymenoptera seem to have higher risk of work disability and refer more frequently a positive effect of VIT on work.
Source: BMJ Open - August 6, 2014 Category: Journals (General) Authors: Paolocci, G., Folletti, I., Toren, K., Muzi, G., Murgia, N. Tags: Open access, Epidemiology, Immunology (including allergy), Occupational and environmental medicine Research Source Type: research

Sibship size, birth order and risk of asthma and allergy: protocol for a systematic review and meta-analysis
The objective of the present systematic review will be to identify, critically appraise and synthesise previous primary studies investigating the association of sibship size and birth order with the risk of asthma and allergic diseases. Methods and analysis The following databases will be searched: AMED, CABI, CINAHL, Embase, Google Scholar, OAIster, Open Access Theses and Dissertations, Open Grey, ProQuest Dissertations & Theses Global, PsycINFO, PubMed, SciELO, Scopus, Web of Science and WHO Global Index Medicus. Studies published up until 31 December 2020 will be eligible. There will be no restrictions by language ...
Source: BMJ Open - August 23, 2021 Category: General Medicine Authors: Lisik, D., Ioannidou, A., Milani, G., Nyassi, S., Özuygur Ermis, S. S., Spolidoro, G. C. I., Goksör, E., Wennergren, G., Nwaru, B. I. Tags: Open access, Immunology (including allergy) Source Type: research

Infant formulas containing hydrolysed protein for prevention of allergic disease and food allergy.
CONCLUSIONS: We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergy. Very low-quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA.In infants at high risk of allergy not exclusively breast fed, very low-quality evidence suggests that prolonged hydrolysed formula feeding compared with CMF feeding reduces infant allergy and infant CMA. Studies have found no difference in childhood allergy and no difference in specific allergy, including infant and childhood asthma, eczema and rhin...
Source: Cochrane Database of Systematic Reviews - March 14, 2017 Category: Journals (General) Authors: Osborn DA, Sinn JK, Jones LJ Tags: Cochrane Database Syst Rev Source Type: research

WITHDRAWN: Infant formulas containing hydrolysed protein for prevention of allergic disease and food allergy.
CONCLUSIONS: We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergy. Very low-quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA.In infants at high risk of allergy not exclusively breast fed, very low-quality evidence suggests that prolonged hydrolysed formula feeding compared with CMF feeding reduces infant allergy and infant CMA. Studies have found no difference in childhood allergy and no difference in specific allergy, including infant and childhood asthma, eczema and rhin...
Source: Cochrane Database of Systematic Reviews - May 25, 2017 Category: General Medicine Authors: Osborn DA, Sinn JK, Jones LJ Tags: Cochrane Database Syst Rev Source Type: research

Skin care interventions in infants for preventing eczema and food allergy.
CONCLUSIONS: Skin care interventions such as emollients during the first year of life in healthy infants are probably not effective for preventing eczema, and probably increase risk of skin infection. Effects of skin care interventions on risk of food allergy are uncertain. Further work is needed to understand whether different approaches to infant skin care might promote or prevent eczema and to evaluate effects on food allergy based on robust outcome assessments. PMID: 33545739 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - February 5, 2021 Category: General Medicine Authors: Kelleher MM, Cro S, Cornelius V, Lodrup Carlsen KC, Skjerven HO, Rehbinder EM, Lowe AJ, Dissanayake E, Shimojo N, Yonezawa K, Ohya Y, Yamamoto-Hanada K, Morita K, Axon E, Surber C, Cork M, Cooke A, Tran L, Van Vogt E, Schmitt J, Weidinger S, McClanahan D, Tags: Cochrane Database Syst Rev Source Type: research

Skin care interventions in infants for preventing eczema and food allergy
CONCLUSIONS: Based on low- to moderate-certainty evidence, skin care interventions such as emollients during the first year of life in healthy infants are probably not effective for preventing eczema; may increase risk of food allergy; and probably increase risk of skin infection. Further study is needed to understand whether different approaches to infant skin care might prevent eczema or food allergy.PMID:36373988 | DOI:10.1002/14651858.CD013534.pub3
Source: Cochrane Database of Systematic Reviews - November 14, 2022 Category: General Medicine Authors: Maeve M Kelleher Rachel Phillips Sara J Brown Suzie Cro Victoria Cornelius Karin C L ødrup Carlsen H åvard O Skjerven Eva M Rehbinder Adrian J Lowe Eishika Dissanayake Naoki Shimojo Kaori Yonezawa Yukihiro Ohya Kiwako Yamamoto-Hanada Kumiko Morita Emma Source Type: research