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High Incidence of Hippocampal Abnormalities in Pediatric Patients with Congenital Cytomegalovirus Infection
Conclusion This study is the first to demonstrate the incidence of hippocampal abnormality to be significantly higher in congenital CMV infection patients than in age-matched controls. Further study is necessary to clarify the associations of HIMAL with other clinical and developmental features. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Neuropediatrics - January 28, 2022 Category: Neurology Authors: Natsume, Takenori Inaba, Yuji Osawa, Yoshihiro Fukuyama, Tetsuhiro Tags: Original Article Source Type: research

Severe Fetal Symptomatic Infection from Human Cytomegalovirus following Nonprimary Maternal Infection: Report of Two Cases
Conclusion: The impact of nonprimary maternal infection on pregnancy outcome is unknown and fetal brain damage in HCMV seroimmune transmitter-mothers can occur as a consequence of maternal reinfection or reactivation for a hypotetic different role of HCMV-primed CD4+ or CD8+ T-cells in fetal brain, with progressive brain lesions coexistent in the first case and with severe unexpected anemia in the second case. A previous maternal HCMV immunity should not exempt to test anemic fetuses for such infection, nor to consider a potential transplacental transmission.
Source: Fetal Diagnosis and Therapy - December 30, 2021 Category: Perinatology & Neonatology Source Type: research

Severe fetal symptomatic infection from human cytomegalovirus following non-primary maternal infection: report of two cases
Conclusion The impact of non-primary maternal infection on pregnancy outcome is unknown and fetal brain damage in HCMV seroimmune transmitter-mothers can occur as a consequence of maternal re-infection or reactiva tion for a hypotetic different role of HCMV-primed CD4+ or CD8+ T-cells in fetal brain, with progressive brain lesions coexistent in the first case and with severe unexpected anemia in the second case. A previous maternal HCMV immunity should not exempt to test anemic fetuses for such infection, nor to consider a potential transplacental transmission.
Source: Fetal Diagnosis and Therapy - December 30, 2021 Category: Perinatology & Neonatology Source Type: research

Congenital CMV infection presenting with massive intracerebral hemorrhage
CONCLUSION: Catastrophic intracerebral hemorrhage has not been previously reported in association with congenital CMV infection. The present case expands the range of potential injuries to the developing brain in congenital CMV infection and raises the possibility of a direct vascular injury.PMID:34308832 | DOI:10.5414/NP301341
Source: Clinical Neuropathology - July 26, 2021 Category: Pathology Authors: Barbra de Vrijer Diana Crowley Delaney Cosma Giulio Muscedere Robert Hammond Source Type: research

MRI findings in children with congenital cytomegalovirus infection retrospectively diagnosed with dried umbilical cord
ConclusionPatients with congenital CMV infection with delayed neurological symptoms show a relatively uniform pattern of parietal-dominant multifocal WM lesions and anterior temporal lesions, with or without polymicrogyria.
Source: Neuroradiology - November 17, 2020 Category: Radiology Source Type: research

A homozygote frameshift mutation in OCLN gene result in Pseudo-TORCH syndrome type I: A case report extending the phenotype with central diabetes insipidus and renal dysfunction.
Abstract Intrauterine infections with the pathogens, including toxoplasmosis, other (syphilis, varicella, mumps, parvovirus, and HIV), rubella, cytomegalovirus, and herpes simplex (TORCH) in susceptible individuals during pregnancy, result in microcephaly, white matter disease, cerebral atrophy, and calcifications in the fetus. Pseudo-TORCH syndrome is an umbrella term, consisting of several syndromes, resultant from different genetic alterations and pathogenetic mechanisms. Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG) is one of these conditions, resultant from biallelic mutations ...
Source: European Journal of Medical Genetics - March 29, 2020 Category: Genetics & Stem Cells Authors: Ekinci F, Yildizdas RD, Horoz OO, Herguner O, Bisgin A Tags: Eur J Med Genet Source Type: research

Prenatal brain MRI of fetuses with Zika virus infection
Conclusion Severe cerebral damage was observed in our series, with indirect findings suggesting that the germinal matrix is the principal target for Zika virus. The lesions are very similar to severe forms of congenital cytomegalovirus and lymphocytic choriomeningitis virus infections.
Source: Pediatric Radiology - April 17, 2016 Category: Radiology Source Type: research

Visual sensory and ocular motor function in children with polymicrogyria: relationship to magnetic resonance imaging
Conclusions All children with PMG had recordable visual function either by visual acuity or VEP testing, however the majority did not show longitudinal improvement in acuity. Seizures may impose limits on visual acuity development. Children with cytomegalovirus-related PMG, microcephaly, and developmental delay can have normal visual acuity. Children with a recordable VEP but without visually guided behaviors may have a defect in sensorimotor transformation.
Source: Journal of American Association for Pediatric Ophthalmology and Strabismus - February 23, 2016 Category: Opthalmology Source Type: research

Fetal Brain Magnetic Resonance Imaging Findings In Congenital Cytomegalovirus Infection With Postnatal Imaging Correlation
We present the prenatal brain MRI findings seen in congenital cytomegalovirus infection and provide postnatal imaging correlation, highlighting the evolution of findings at different times in prenatal and postnatal developments.
Source: Seminars in Ultrasound, CT and MRI - April 30, 2015 Category: Radiology Source Type: research

Fetal brain MRI findings in congenital cytomegalovirus infection with postnatal imaging correlation
Fetal brain MRI is a powerful tool in the diagnosis of symptomatic congenital CMV infection, requiring a detailed search for specific features. A combination of anterior temporal lobe abnormalities, white matter lesions, and polymicrogyria are especially predictive. Fetal MRI may provide a unique opportunity to detect anterior temporal cysts and occipital horn septations, since dilation of these areas may decrease later in development. Cortical migration abnormalities, white matter abnormalities, cerebellar dysplasia and periventricular calcifications are often better depicted on postnatal imaging, but can also be detected on fetal MRI.
Source: Seminars in Ultrasound CT and MRI - April 3, 2015 Category: Radiology Authors: Lauren W. Averill, Vinay V.R. Kandula, Yakup Akyol, Monica Epelman Source Type: research

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