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Total 11881 results found since Jan 2013.
CYP2C19 Loss-of-Function Variants Associated with Long-term Ischemic Stroke Events During Clopidogrel Treatment in the Chinese Population
This study aims to determine whether CYP2C19 loss-of-function (LoF) variants were associated with long-term ischemic stroke risk in Chinese primary care patients treated with clopidogrel. Patients treated with clopidogrel were ascertained from a Chinese Electronic Medical Record linked with biobank for a retrospective cohort study. Their medical information was examined for the period from January 2018 to December 2021. Two CYP2C19 major loss of function variants (*2:rs4244285, *3: rs4986893) were genotyped. The clinical outcome was ischemic stroke event. Cox regression analysis was used to evaluate the association between...
Source: Clinical Pharmacology and Therapeutics - August 22, 2023 Category: Drugs & Pharmacology Authors: Peng Wu Ziqing Liu Zijian Tian Benrui Wu Jian Shao Qian Li Zhaoxu Geng Ying Pan Ke Lu Qiang Wang Tao Xu Kaixin Zhou Source Type: research
Evaluation of Large-Scale Proteomics for Prediction of Cardiovascular Events
CONCLUSIONS AND RELEVANCE: A protein risk score was significantly associated with ASCVD events in primary and secondary event populations. When added to clinical risk factors, the protein risk score and polygenic risk score both provided statistically significant but modest improvement in discrimination.PMID:37606673 | DOI:10.1001/jama.2023.13258
Source: Atherosclerosis - August 22, 2023 Category: Cardiology Authors: Hannes Helgason Thjodbjorg Eiriksdottir Magnus O Ulfarsson Abhishek Choudhary Sigrun H Lund Erna V Ivarsdottir Grimur Hjorleifsson Eldjarn Gudmundur Einarsson Egil Ferkingstad Kristjan H S Moore Narimon Honarpour Thomas Liu Huei Wang Thomas Hucko Marc S S Source Type: research
Impact of age on pre-procedural TIMI flow in STEMI patients undergoing primary percutaneous coronary intervention
CONCLUSION: The present study shows that among STEMI patients undergoing primary PCI, more advanced age represents an independent predictor of preprocedural IRA patency. Future studies will define the implications on procedural results and long-term prognosis.PMID:37605955 | DOI:10.2459/JCM.0000000000001482
Source: Atherosclerosis - August 22, 2023 Category: Cardiology Authors: Monica Verdoia Rocco Gioscia Orazio Viola Marta Francesca Brancati Pier Luigi Sold à Andrea Rognoni Giuseppe De Luca Novara Atherosclerosis Study Group (NAS) Source Type: research
Advances in drug delivery to atherosclerosis: Investigating the efficiency of different nanomaterials employed for different type of drugs
Mater Today Bio. 2023 Aug 7;22:100767. doi: 10.1016/j.mtbio.2023.100767. eCollection 2023 Oct.ABSTRACTAtherosclerosis is the build-up of fatty deposits in the arteries, which is the main underlying cause of cardiovascular diseases and the leading cause of global morbidity and mortality. Current pharmaceutical treatment options are unable to effectively treat the plaque in the later stages of the disease. Instead, they are aimed at resolving the risk factors. Nanomaterials and nanoparticle-mediated therapies have become increasingly popular for the treatment of atherosclerosis due to their targeted and controlled release of...
Source: Atherosclerosis - August 21, 2023 Category: Cardiology Authors: Binura Perera Yuao Wu Nam-Trung Nguyen Hang Thu Ta Source Type: research
Quantitative imaging biomarkers of coronary plaque morphology: insights from EVAPORATE
CONCLUSION: Plaques in the IPE-treated patients acquired more characteristics of stability. Reliable assessment using histologically validated analysis of individual response is possible at 9 months, with sustained stabilization at 18 months, providing a quantitative basis to elucidate drug mechanism and assess individual patient response.PMID:37600044 | PMC:PMC10435977 | DOI:10.3389/fcvm.2023.1204071
Source: Atherosclerosis - August 21, 2023 Category: Cardiology Authors: Andrew J Buckler Gheorghe Doros April Kinninger Suvasini Lakshmanan Viet T Le Peter Libby Heidi T May Joseph B Muhlestein John R Nelson Anna Nicolaou Sion K Roy Kashif Shaikh Chandana Shekar John A Tayek Luke Zheng Deepak L Bhatt Matthew J Budoff Source Type: research
The role of cepharanthine as an anti-atherosclerotic agent in rats
Pak J Pharm Sci. 2023 Jul;36(4):1073-1077.ABSTRACTThis investigation assessed the potential of cepharanthine (CEP), a compound from Stephania cepharantha Hayata, in mitigating atherosclerosis in a hyperlipidemic rat model. Using Wistar rats, four distinct diet and drug treatment groups were established: a high-fat high sucrose diet (HFHS), HFHS supplemented with intraperitoneal cepharanthine (HFHS-C) or oral atorvastatin (HFHS-A) from the 8th week, and a normal-fat diet (NFD). The study aimed to evaluate diet and drug impact on aortic histopathological changes over 16 weeks. Our results revealed significant atherosclerosis...
Source: Atherosclerosis - August 21, 2023 Category: Cardiology Authors: - Adnan Iqbal - Rahila Najam - Saira Saeed Khan - Sumera Imran - Muhammad Osama - Anosh Tahir - Muhammad Imran - Bilal Jawed - Zeeshan Ahmed - Azfar Athar Ishaqui Source Type: research
Effect of Alirocumab Added to High-Intensity Statin on Platelet Reactivity and Non-coding RNAs in AMI Patients: A Substudy of the PACMAN-AMI Trial
CONCLUSIONS: Among AMI patients receiving DAPT with a potent P2Y12 inhibitor, alirocumab had no significant effect on platelet reactivity as assessed by PRU and platelet-derived non-coding RNAs.PMID:37595625 | DOI:10.1055/a-2156-7872
Source: Thrombosis and Haemostasis - August 18, 2023 Category: Hematology Authors: Yasushi Ueki Jonas H äner Sylvain Losdat Giuseppe Gargiulo Hiroki Shibutani Sarah B är Tatsuhiko Otsuka Raminta Kavaliauskaite Vera Mitter Fabrice Temperli David Spirk Stefan Stortecky George Siontis Marco Valgimigli Stephan Windecker Clemens Gutmann Ko Source Type: research
Drug landscape in patients receiving general outpatient palliative care in Germany: results from a retrospective analysis of 10,464 patients
CONCLUSIONS: Our results support the role of GOPC as an important element in improving pharmacological symptom control and deprescription to improve quality of life of patients at the end of their life.PMID:37596590 | DOI:10.1186/s12904-023-01231-3
Source: Cancer Control - August 18, 2023 Category: Cancer & Oncology Authors: Sven H Loosen Jacqueline Schwartz Steven Grewe Sarah Krieg Andreas Krieg Tom Luedde Yann-Nicolas Batzler Karel Kostev Martin Neukirchen Christoph Roderburg Source Type: research
Effect of Alirocumab Added to High-Intensity Statin on Platelet Reactivity and Non-coding RNAs in AMI Patients: A Substudy of the PACMAN-AMI Trial
CONCLUSIONS: Among AMI patients receiving DAPT with a potent P2Y12 inhibitor, alirocumab had no significant effect on platelet reactivity as assessed by PRU and platelet-derived non-coding RNAs.PMID:37595625 | DOI:10.1055/a-2156-7872
Source: Thrombosis and Haemostasis - August 18, 2023 Category: Hematology Authors: Yasushi Ueki Jonas H äner Sylvain Losdat Giuseppe Gargiulo Hiroki Shibutani Sarah B är Tatsuhiko Otsuka Raminta Kavaliauskaite Vera Mitter Fabrice Temperli David Spirk Stefan Stortecky George Siontis Marco Valgimigli Stephan Windecker Clemens Gutmann Ko Source Type: research
Prognostic value of coronary atherosclerosis and CAC score for the risk of chemotherapy-related cardiac dysfunction (CTRCD): The protocol of ANTEC study
This study is listed on cinicaltrials.gov with identifier NCT05118178.PMID:37590267 | DOI:10.1371/journal.pone.0288146
Source: Atherosclerosis - August 17, 2023 Category: Cardiology Authors: Anna Borowiec Patrycja Ozdowska Magdalena Rosinska Agnieszka Jagiello-Gruszfeld Slawomir Jasek Joanna Waniewska Beata Kotowicz Hanna Kosela-Paterczyk Elzbieta Lampka Agata Makowka Ma łgorzata Fuksiewicz Magdalena Chojnacka Agnieszka Zebrowska Katarzyna G Source Type: research
Atorvastatin lowers < sup > 68 < /sup > Ga-DOTATATE uptake in coronary arteries, bone marrow and spleen in individuals with type 2 diabetes
CONCLUSIONS/INTERPRETATION: 68Ga-DOTATATE uptake across the cardio-haematopoietic axis was lower after statin therapy in individuals with type 2 diabetes. Therefore, 68Ga-DOTATATE is promising as a metric for vascular and haematopoietic inflammation in intervention studies using anti-inflammatory therapeutics in individuals with type 2 diabetes.TRIAL REGISTRATION: ClinicalTrials.gov NCT05730634.PMID:37581619 | DOI:10.1007/s00125-023-05990-9
Source: Atherosclerosis - August 15, 2023 Category: Cardiology Authors: Reindert F Oostveen Yannick Kaiser Mia R St åhle Nick S Nurmohamed Evangelos Tzolos Marc R Dweck Jeffrey Kroon Andrew J Murphy Damini Dey Piotr J Slomka Hein J Verberne Erik S G Stroes Nordin M J Hanssen Source Type: research
A meta-analysis of randomized controlled trials of statin-based therapy in patients with COVID-19
CONCLUSION: A critical appraisal of published randomized controlled trials on statin therapy in COVID-19 did not show any significant effect on mortality, the risk of transfer to intensive care, or mechanical ventilation.PMID:37578125 | DOI:10.5414/CP204446
Source: International Journal of Clinical Pharmacology and Therapeutics - August 14, 2023 Category: Drugs & Pharmacology Authors: Guoying Kao Yunlin Chen Jun Xiao Jinqi Fan Source Type: research
Development and validation of a sensitive LC-MS/MS method for simultaneous analysis of clopidogrel and simvastatin and their main metabolites in beagles: Application to pharmacokinetic drug interactions
This study developed and validated an LC-MS/MS method for the simultaneous determination of CLP, clopidogrel carboxylic acid (CLPCA), 2-oxo-clopidogrel (2-O-CLP), SV, and simvastatin hydroxy acid (SVA) in beagle plasma. Chromatographic separation was achieved on an InfinityLab Poroshell 120 SB-C8 column (2.1 × 100 mm, 2.7 μm) using methanol and 0.1% formic acid in water as the mobile phase at a flow rate of 0.3 mL/min in gradient mode. The lower limits of quantification are 0.1, 0.8, 0.05, 0.05, and 0.05 ng/mL for CLP, CLPCA, 2-O-CLP, SV, and SVA, respectively. The selectivity, linearity, accuracy, precision, extraction ...
Source: Biomedical Chromatography : BMC - August 14, 2023 Category: Biomedical Science Authors: Xiao Tang Yu Zhang Yue Yi Zhang Zunjian Zhang Yuan Tian Source Type: research
