Filtered By:
Specialty: Cytology
This page shows you your search results in order of date. This is page number 10.
Order by Relevance | Date
Total 78694 results found since Jan 2013.
Autophagy in colitis-associated colon cancer: exploring its potential role in reducing initiation and preventing IBD-Related CAC development
Autophagy. 2023 Sep 18. doi: 10.1080/15548627.2023.2259214. Online ahead of print.ABSTRACTColitis-associated colon cancer (CAC) is a distinct form of colorectal cancer that emerges from prolonged colitis in individuals with inflammatory bowel disease (IBD). Chronic inflammation is considered as the most critical contributor to the development and progression of CAC, with the degree and persistence of the inflammatory response being the primary drivers of CAC progression in individuals with IBD. Macroautophagy/autophagy, which is a cellular process that aids in preserving the intestinal mucosal barrier and regulating intest...
Source: Autophagy - September 19, 2023 Category: Cytology Authors: Xuanhong Jin Liangkun You Jincheng Qiao Weidong Han Hongming Pan Source Type: research
CSNK1A1/CK1 α suppresses autoimmunity by restraining the CGAS-STING1 signaling
Autophagy. 2023 Sep 18:1-18. doi: 10.1080/15548627.2023.2256135. Online ahead of print.ABSTRACTSTING1 (stimulator of interferon response cGAMP interactor 1) is the quintessential protein in the CGAS-STING1 signaling pathway, crucial for the induction of type I IFN (interferon) production and eliciting innate immunity. Nevertheless, the overactivation or sustained activation of STING1 has been closely associated with the onset of autoimmune disorders. Notably, the majority of these disorders manifest as an upregulated expression of type I interferons and IFN-stimulated genes (ISGs). Hence, strict regulation of STING1 activi...
Source: Autophagy - September 19, 2023 Category: Cytology Authors: Mingyu Pan Tongyu Hu Jiao Lyu Yue Yin Jing Sun Quanyi Wang Lingxiao Xu Haiyang Hu Chen Wang Source Type: research
Proteogenomics in Cancer: Then and Now
In conclusion, proteogenomics has a promising future as it clarifies the functional consequences of many unannotated genomic abnormalities or noncanonical variants and identifies driver genes and novel therapeutic targets across cancers, which would substantially accelerate the development of precision oncology.PMID:37725793 | DOI:10.1021/acs.jproteome.3c00196
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Xiu-Yun Wang Yan-Ming Xu Andy T Y Lau Source Type: research
The next-generation oral selective estrogen receptor degrader camizestrant (AZD9833) suppresses ER+ breast cancer growth and overcomes endocrine and CDK4/6 inhibitor resistance
In this study, we evaluated the preclinical pharmacology and efficacy of the next-generation oral SERD camizestrant (AZD9833) and assessed ER co-targeting strategies by combining camizestrant with CDK4/6 inhibitors (CDK4/6i) and PI3K/AKT/mTOR-targeted therapy in models of progression on CDK4/6i and/or ET. Camizestrant demonstrated robust and selective ER degradation, modulated ER-regulated gene expression, and induced complete ER antagonism and significant anti-proliferation activity in ESR1 wild-type (ESR1wt) and mutant (ESR1m) breast cancer cell lines and patient-derived xenograft (PDX) models. Camizestrant also delivere...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Mandy Lawson Natalie Cureton Susana Ros Azadeh Cheraghchi-Bashi-Astaneh Jelena Urosevic Sophie D'Arcy Oona Delpuech Michelle DuPont David I Fisher Eric T Gangl Hilary Lewis Dawn Trueman Neha Wali Stuart Charles Williamson Jennifer Moss Elodie Montaudon H Source Type: research
Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair
CONCLUSIONS: In this study, we decipher the molecular processes behind synergistic interactions between chemotherapy and HDAC inhibition. Moreover, we report novel mechanisms to overcome drug resistance in SCLC, which may be relevant to increase the therapeutic success.PMID:37725585 | DOI:10.1158/1078-0432.CCR-23-1795
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Anna Solta Kristiina Boettiger Ildik ó Kovács Christian Lang Zsolt Megyesfalvi Franziska Ferk Miroslav Mi šík Konrad Hoetzenecker Clemens Aigner Christian R Kowol Siegfried Knasmueller Michael Grusch Be áta Szeitz Melinda Rezeli Balazs Dome Karin Sch Source Type: research
Integration of genomic sequencing drives therapeutic targeting of PDGFRA in T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma
CONCLUSIONS: Refractory T-ALL has not been fully characterized. Alterations in PDGFRA or other targetable kinases may inform therapy for patients with refractory T-ALL who otherwise have limited treatment options. Clinical genomic profiling, in real time, is needed for fully informed therapeutic decision making.PMID:37725576 | DOI:10.1158/1078-0432.CCR-22-2562
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Jonathan Paolino Boris Dimitrov Beth Apsel Winger Angelica Sandoval-Perez Amith Vikram Rangarajan Nicole Ocasio-Martinez Harrison K Tsai Yuting Li Amanda L Robichaud Delan Khalid Charlie Hatton Riaz Gillani Petri Polonen Anthony Dilig Giacomo Gotti Julia Source Type: research
Novel clinical trial designs with dose optimization to improve long-term outcomes
Clin Cancer Res. 2023 Sep 19. doi: 10.1158/1078-0432.CCR-23-2222. Online ahead of print.ABSTRACTConventional designs for choosing a dose for a new therapy may select doses that are unsafe or ineffective, and fail to optimize progression free survival time, overall survival time, or remission duration. We explain and illustrate limitations of conventional dose finding designs, and make four recommendations to address these problems. When feasible, a dose-finding design should account for long-term outcomes, include screening rules that drop unsafe or ineffective doses, enroll an adequate sample size, and randomize patients ...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Peter F Thall Yong Zang Andrew G Chapple Ying Yuan Ruitao Lin David Marin Pavlos Msaouel Source Type: research
RANK expression as an independent predictor for response to neoadjuvant chemotherapy in luminal-like breast cancer - a translational insight from the GeparX trial
CONCLUSIONS: We report RANK expression to be an independent predictive biomarker for response to NACT in luminal-like breast cancer patients.PMID:37725572 | DOI:10.1158/1078-0432.CCR-23-1801
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Theresa Link Jens-Uwe Blohmer Wolfgang D Schmitt Jan Dominik Kuhlmann Marianne Just Michael Untch Oliver Stotzer Peter A Fasching Marc Thill Mattea Reinisch Andreas Schneeweiss Pauline Wimberger Sabine Seiler Jens Huober Christian Jackisch Kerstin Rhiem C Source Type: research
Byrsonima sericea Ethanol Extract Protected PC12 Cells from the Oxidative Stress and Apoptosis Induced by 6-Hydroxydopamine
This study aimed to evaluate the cytoprotective activity of the B. sericea ethanolic extract (BSEE) against the cytotoxicity induced by 6-hydroxydopamine (6-OHDA) in PC12 cells, an in vitro model of parkinsonism. The identification of phenolic compounds in the extract by HPLC-DAD revealed the presence of geraniin, rutin, isoquercetin, kaempferol 3-O-β-rutinoside, and quercetin. The BSEE (75-300 µg/mL) protected PC12 cells from toxicity induced by 6-OHDA (25 µg/mL), protected cell membrane integrity and showed antioxidant activity. BSEE was able to decrease nitrite levels, glutathione depletion, and protect cells from 6-...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Albert Layo Costa de Assis Patricia de Ara újo Rodrigues Selene Maia de Morais Ana Livya Moreira Rodrigues Jessica Maria Pessoa Gomes Tyciane de Souza Nascimento Alfaete Vieira Oliveira Mayara Sandrielly Soares de Aguiar Geanne Matos de Andrade Source Type: research
Phytohormones regulate asexual Toxoplasma gondii replication
Parasitol Res. 2023 Sep 19. doi: 10.1007/s00436-023-07968-3. Online ahead of print.ABSTRACTThe protozoan Toxoplasma gondii (T. gondii) is a zoonotic disease agent causing systemic infection in warm-blooded intermediate hosts including humans. During the acute infection, the parasite infects host cells and multiplies intracellularly in the asexual tachyzoite stage. In this stage of the life cycle, invasion, multiplication, and egress are the most critical events in parasite replication. T. gondii features diverse cell organelles to support these processes, including the apicoplast, an endosymbiont-derived vestigial plastid ...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Tina Wagner Berit Bangoura Stefanie Wiedmer Arwid Daugschies Ildiko Rita Dunay Source Type: research
Multi-omics approaches identify novel prognostic biomarkers of autophagy in uveal melanoma
CONCLUSION: We identified six novel potential prognostic biomarkers in UVM, all of which are associated with autophagy and TME. These findings will shed new light on UVM therapy with inhibitors targeting these biomarkers expected to regulate autophagy and reshape the TME, significantly improving UVM treatment outcomes.PMID:37725244 | DOI:10.1007/s00432-023-05401-x
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Wenke Jin Lifeng Wu Lei Hu Yuqi Fu Zhichao Fan Yi Mou Ke Ma Source Type: research
BATF2 enhances pro-inflammatory cytokine responses in macrophages and improves early host defense against pulmonary < em > Klebsiella pneumoniae < /em > infection
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 19. doi: 10.1152/ajplung.00441.2022. Online ahead of print.ABSTRACTBasic leucine zipper transcription factor ATF-like 2 (BATF2) is a transcription factor that is emerging as an important regulator of the innate immune system. BATF2 is among the top upregulated genes in human alveolar macrophages treated with LPS, but the signaling pathways that induce BATF2 expression in response to Gram-negative stimuli are incompletely understood. In addition, the role of BATF2 in the host response to pulmonary infection with a Gram-negative pathogen like Klebsiella pneumoniae (Kp) is not know...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 19, 2023 Category: Cytology Authors: Rick van der Geest Hern án F Peñaloza Zeyu Xiong Shekina Gonzalez-Ferrer Xiaojing An Huihua Li Hongye Fan Mohammadreza Tabary S Mehdi Nouraie Yanwu Zhao Yingze Zhang Kong Chen Jonathan K Alder William G Bain Janet S Lee Source Type: research
The hemodynamic interplay between pulmonary ischemia-reperfusion injury and right ventricular function in lung transplantation: A translational porcine model
In conclusion, we demonstrate a delicate balance between development of pulmonary ischemia-reperfusion injury and right ventricular function during lung transplantation. Furthermore, we provide a physiological basis for potential benefit of extracorporeal life support technology.PMID:37724349 | DOI:10.1152/ajplung.00281.2022
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 19, 2023 Category: Cytology Authors: Michaela Orlitov á Tom Verbelen Anna E Frick Arno Vanstapel Dieter Van Beersel Sofie Ordies Jan Van Slambrouck Janne Kaes Jin Xin Walter Coudyzer Stijn E Verleden Geert M Verleden Bart M Vanaudenaerde Dirk E Van Raemdonck Robin Vos Laurens J Ceulemans Pi Source Type: research
Three-dimensional electrical impedance tomography (EIT) to study regional ventilation/perfusion (V/Q ̇) ratios in anesthetized pigs
This study aimed to develop a 3D method for assessing ventilation/perfusion (V/Q̇) ratios in a pig model of hemodynamic perturbations using electrical impedance tomography (EIT). In order to evaluate the physiological coherence of changes in EIT-derived V/Q̇ ratios, global EIT-derived V/Q̇ mismatches were compared with global gold-standards. The study found regional heterogeneity in the distribution of V/Q̇ ratios in both the ventrodorsal and craniocaudal directions. Although global EIT-derived indices of V/Q̇ mismatch consistently underestimated both low and high V/Q̇ mismatch compared to global gold standards, the ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 19, 2023 Category: Cytology Authors: Shannon Larrabee Sarah Nugen Alejandro Bruhn Ian Porter Symon Stowe Andy Adler Manuel Martin-Flores Joaquin Araos Source Type: research
Pathophysiological Aspects and Therapeutic Armamentarium of Alzheimer's Disease: Recent Trends and Future Development
Cell Mol Neurobiol. 2023 Sep 19. doi: 10.1007/s10571-023-01408-7. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the primary cause of dementia and is characterized by the death of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of tau protein, and the formation of neurofibrillary tangles within the cells. AD is also associated with other pathologies such as neuroinflammation, dysfunction of synaptic connections and circuits, disorders in mitochondrial function and energy production, epigenetic changes, and abnormalities in the vascular system. Despite extensive research con...
Source: Cellular and Molecular Neurobiology - September 19, 2023 Category: Cytology Authors: Bhavarth P Dave Yesha B Shah Kunal G Maheshwari Kaif A Mansuri Bhadrawati S Prajapati Humzah I Postwala Mehul R Chorawala Source Type: research
