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Specialty: Cytology
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Total 78694 results found since Jan 2013.
Multifunctional nanozyme-reinforced copper-coordination polymer nanoparticles for drug-resistance bacteria extinction and diabetic wound healing
CONCLUSIONS: The Cu-CPNs@EPL complex has impressive antioxidant properties and antibacterial effects, making it a promising solution for treating drug-resistant bacterial infections in chronic wounds. The complex's ability to neutralize multiple ROS and reduce ROS-induced inflammation can help relieve inflammation at the wound site. Schematic illustration of the ROS scavenging and bacteriostatic function induced by Cu-CPNs@EPL nanozyme in the treatment of MRSA-infected wounds.PMID:37723499 | PMC:PMC10506277 | DOI:10.1186/s40824-023-00429-z
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Jiahui Zhao Tengfei Xu Jichao Sun Haitao Yuan Mengyun Hou Zhijie Li Jigang Wang Zhen Liang Source Type: research
Schweinfurthiamide, a new alkaloid isolated from the tuber roots of < em > Asparagus flagellaris < /em > Baker (Liliaceae)
Nat Prod Res. 2023 Sep 18:1-7. doi: 10.1080/14786419.2023.2257358. Online ahead of print.ABSTRACTThe phytochemical investigations of the tuber roots of Asparagus flagellaris led to the isolation of a new alkaloid, schweinfurthiamide (1) and eight known compounds. The structures of the isolated compounds were elucidated using spectroscopic techniques 1D and 2D NMR (1H, 13C, COSY, HMBC, HMQC, HSQC-TOCSY). The absolute configuration of 1 was unambiguously determined using DP4+ calculations. Compound 1 showed significant cytotoxicity against MCF-7 (breast cancer), NCI-H460 (lung cancer), and Hela (cervical cancer) cancer cell ...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Elodie Nguelami Kamdeu Ad èle Nicaise Menye Nomo Abdou Tchoukoua Orleans Ngomo Pascal Djimeli Douanla Marguerite Hortence Tchuendem Kenmogne Yoshihito Shiono Turibio Kuiate Tabopda Source Type: research
Resveratrol ameliorates diabetic encephalopathy through PDE4D/PKA/Drp1 signaling
This study illustrated the role of PDE4D in DE and investigated whether resveratrol protected against DE via inhibiting PDE4D. db/db male mice and hippocampus cell line (HT22) were used to investigate the role of PDE4D and the protective effect of resveratrol on cognitive function under high glucose (HG). PDE4D overexpression or knockdown lentivirus and PKA specific inhibitor H89 were used to further identify the indispensable role of PDE4D/PKA signaling pathway in resveratrol's amelioration effect of neurotoxicity. Resveratrol attenuated cognitive impairment in db/db mice, reduced PDE4D protein, restored the impaired mito...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Yanjuan Cao Wen Sun Chang Liu Zihui Zhou Zongli Deng Mingjie Zhang Meng Yan Xiaoxing Yin Xia Zhu Source Type: research
Insights into mustard gas keratopathy- characterizing corneal layer-specific changes in mice exposed to nitrogen mustard
In this study, we aimed to develop a mouse model of MGK by using ocular NM exposure, and describe the subsequent structural changes analyzed across the different layers of the cornea. A 3 μL solution of 0.25 mg/mL or 5 mg/mL NM was applied to the center of the cornea via a 2-mm filter paper for 5 min. Mice were evaluated prior to and after exposure on days 1, 3, 7, 14, and 28 for 4 weeks using slit lamp examination with fluorescein staining. Anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscopy (IVCM) tracked changes in the epithelium, stroma, and endothelium of the cornea. Histologic eval...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Hamid Alemi Shima Dehghani Katayoon Forouzanfar Pier Luigi Surico Akitomo Narimatsu Aytan Musayeva Sina Sharifi Shudan Wang Thomas H Dohlman Jia Yin Yihe Chen Reza Dana Source Type: research
Robust expression of the TRPC1 channel associated with photoreceptor loss in the rat retina
In this study, we examined by Western blot the expression of TRPC1 in healthy control rat retinas (Sprague-Dawley, SD) and retinas with RP (P23H-1 rats). We also analyzed its specific cellular distribution by immunofluorescence to recognize changes during neurodegeneration and to determine whether its presence is consistent with high basal calcium levels and cellular survival in degenerating retinas. We found that TRPC1 immunostaining was widely distributed across the retina in both rat strains, SD and P23H, and its expression levels significantly increased in the retinas with advanced degeneration compared to the age-cont...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Elena Caminos Marina Murillo-Mart ínez Mar ía García-Belando Jos é Julio Cabanes-Sanchís Juan R Martinez-Galan Source Type: research
Deciphering mechanisms of cardiomyocytes and non-cardiomyocyte transformation in myocardial remodeling of permanent atrial fibrillation
CONCLUSIONS: This study has discovered the presence of de-differentiated myocardial cells, a decrease in endothelial progenitor cells, a shift in the secretion profile of fat cells, and an amplified inflammatory response in AF. These findings could offer crucial insights for future research on AF and serve as valuable references for investigating novel therapeutic approaches for AF.PMID:37722560 | DOI:10.1016/j.jare.2023.09.012
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Yixuan Sheng Yin-Ying Wang Yuan Chang Dongting Ye Liying Wu Hongen Kang Xiong Zhang Xiao Chen Bin Li Daliang Zhu Ningning Zhang Haisen Zhao Aijun Chen Haisheng Chen Peilin Jia Jiangping Song Source Type: research
Dimethyl fumarate attenuates cholestatic liver injury by activating the NRF2 and FXR pathways and suppressing NLRP3/GSDMD signaling in mice
Exp Cell Res. 2023 Sep 16:113781. doi: 10.1016/j.yexcr.2023.113781. Online ahead of print.ABSTRACTThe progression of cholestasis is characterized by excessive accumulation of bile acids (BAs) in the liver, which leads to oxidative stress (OS), inflammation and liver injury. There are currently limited treatments for cholestasis. Therefore, appropriate drugs for cholestasis treatment need to be developed. Dimethyl fumarate (DMF) has been widely used in the treatment of various diseases and exerts antioxidant and anti-inflammatory effects, but its effect on cholestatic liver disease remains unclarified. We fed mice 3,5-dieth...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Ziqian Xu Wan Tang Qiaoling Xie Xinyu Cao Mengni Zhang Xiaoxun Zhang Jin Chai Source Type: research
Protective effect of cornuside on OGD/R injury in SH-SY5Y cells and its underlying mechanism
In this study, we treated SH-SY5Y cells with OGD/R to simulated ischemia/reperfusion (I/R) injury. Using high-throughput transcriptome sequencing, differentially expressed genes were analyzed in the OGD/R group versus the OGD/R + Cornuside (10 μmol/L) group to explore the neuroprotective mechanisms of Cornuside. The differentially expressed genes were mainly enriched in apoptosis signaling pathway, cell cycle, DNA damage and repair, and p38/JNK MAPK and p53 signaling pathways. The results showed that OGD/R significantly reduced the survival of SH-SY5Y cells, induced apoptosis, disrupted the nucleus, promoted the release o...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Xinyu Wang Chao Yan Chaoyun Wang Xiaoyan Xu Zhihao Liu Wang Xin Jianwei Gong Source Type: research
Corneal endothelial cell cultures from organotypic preservation of older donor corneas are suitable for advanced cell therapy
CONCLUSIONS: Our results indicate that it is possible to obtain functional hCEC cultures in eye banks, using simplified and standardized protocols, from older donor corneas (> 60 years of age), previously preserved under organotypic culture conditions. This tissue is more readily available in our setting, due to the profile of the donor population or due to the low endothelial count (< 2000 cells/mm2) of the donated cornea.PMID:37722372 | DOI:10.1159/000533701
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Caterina Aloy-Revert é Francisco Bandeira Nausica Otero Aida Rebollo-Morell Nuria Nieto-Nicolau Jos é Álvaro P Gomes Jos é L Güell Ricardo P Casaroli-Marano Source Type: research
HDAC inhibitors: Promising agents for leukemia treatment
Biochem Biophys Res Commun. 2023 Sep 14;680:61-72. doi: 10.1016/j.bbrc.2023.09.023. Online ahead of print.ABSTRACTThe essential role of epigenetic modification in the pathogenesis of a series of cancers have gradually been recognized. Histone deacetylase (HDACs), as well-known epigenetic modulators, are responsible for DNA repair, cell proliferation, differentiation, apoptosis and angiogenesis. Studies have shown that aberrant expression of HDACs is found in many cancer types. Thus, inhibition of HDACs has provided a promising therapeutic approach alternative for these patients. Since HDAC inhibitor (HDACi) vorinostat was ...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Yun Deng Qian Cheng Jing He Source Type: research
Corrigendum to Cancer associated fibroblasts-derived exosomes contribute to radioresistance through promoting colorectal cancer stem cells phenotype Exp Cell Res. 2020 Jun 15; 391(2):111956
Exp Cell Res. 2023 Sep 16;432(1):113776. doi: 10.1016/j.yexcr.2023.113776. Online ahead of print.NO ABSTRACTPMID:37722314 | DOI:10.1016/j.yexcr.2023.113776
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Lei Liu Zhe Zhang Lei Zhou Liya Hu Cun Yin Defeng Qing Shanshan Huang Xiuyu Cai Yuan Chen Source Type: research
Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases
Vision Res. 2023 Sep 16;213:108317. doi: 10.1016/j.visres.2023.108317. Online ahead of print.ABSTRACTGene therapy is a flourishing field with the potential to revolutionize the treatment of genetic diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient genome editing. Although CRISPR-Cas9 has demonstrated promising potential applications in various genetic disorders, it faces limitations in simultaneously targeting multiple genes. Novel CRISPR systems, such as Cas12 and Cas13, have been developed to overcome these challenges, enabling multiplexing and providing unique advantages. Cas13, in...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Fabio Bigini Soo Hyeon Lee Young Joo Sun Yang Sun Vinit B Mahajan Source Type: research
Breaking down tumor thrombus: Current strategies for medical management
Thromb Res. 2023 Sep 13;230:144-151. doi: 10.1016/j.thromres.2023.09.004. Online ahead of print.ABSTRACTTumor thrombus, the intravascular extension of tumor into adjacent blood vessels, is frequently encountered in patients with renal cell carcinoma and hepatocellular carcinoma, and often involves the abdominal vasculature including the renal vein, portal vein, and the inferior vena cava. While a bland thrombus is composed of platelets and fibrin, in contrast, a tumor thrombus refers to an organized collection of tumor cells. Though oftentimes detected incidentally on imaging, tumor thrombus may have significant clinical i...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Harsha Tathireddy Douglas Rice Kylee Martens Sudeep Shivakumar Joseph Shatzel Source Type: research
Generation of a human iPSC line CIPi003-A from a patient with focal epilepsy harboring a heterozygous mutation in DEPDC5 gene
Stem Cell Res. 2023 Aug 28;72:103195. doi: 10.1016/j.scr.2023.103195. Online ahead of print.ABSTRACTThe DEPDC5 gene (OMIM 614191) has been proven to be a frequent cause of familial and sporadic focal epilepsy. A human induced pluripotent stem cell (iPSC) line was generated from a child diagnosed with focal epilepsy, which was caused by DEDPC5 mutation. The iPSC line expresses high pluripotency markers, carries the DEDPC5 mutation, and can differentiate into three germ layers in vitro. The iPSC lines offer a promising technique for studying the pathogenesis and conducting drug screening of DEDPC5-related epilepsy.PMID:37722...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Mengxiao Shen Shiqi Fan Fan Wu Peidi Cheng Yanyan Gao Ping Zheng Shuo Feng Xinna Ji Qian Chen Xue Zhang Source Type: research
Overview of CD70 as a Potential Therapeutic Target for Osteosarcoma
J Immunol. 2023 Oct 1;211(7):1067-1072. doi: 10.4049/jimmunol.2200591.ABSTRACTOsteosarcoma is a primary malignant bone tumor. Effective chemotherapy regimens for refractory disease are scarce, accounting for no improvement in survival. Immune-based cell therapies have emerged as novel alternatives. However, advancements with these therapies have been seen mostly when immune cells are armed to target specific tumor Ags. Recent studies identified cluster of differentiation 70 (CD70) as a promising target to osteosarcoma particularly because CD70 is highly expressed in osteosarcoma lung metastases (Pahl et al. 2015. Cancer Ce...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Emily Rav Shinji Maegawa Vidya Gopalakrishnan Nancy Gordon Source Type: research
