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Total 120827 results found since Jan 2013.
Emerging Applications of Hydroxypropyl Methylcellulose Acetate Succinate: Different Aspects in Drug Delivery and Its Commercial Potential
AAPS PharmSciTech. 2023 Sep 15;24(7):188. doi: 10.1208/s12249-023-02645-1.ABSTRACTHydroxypropyl methylcellulose acetate succinate (HPMCAS) has multi-disciplinary applications spanning across the development of drug delivery systems, in 3D printing, and in tissue engineering, etc. HPMCAS helps in maintaining the drug in a super-saturated condition by inhibiting its precipitation, thereby increasing the rate and extent of dissolution in the aqueous media. HPMCAS has several distinctive characteristics, such as being amphiphilic in nature, having an ionization pH, and a succinyl and acetyl substitution ratio, all of which are...
Source: AAPS PharmSciTech - September 15, 2023 Category: Drugs & Pharmacology Authors: Manisha Choudhari Shantanu Damle Ranendra Narayan Saha Sunil Kumar Dubey Gautam Singhvi Source Type: research
The Contribution of the AT1 Receptor to Erythropoiesis
Biochem Pharmacol. 2023 Sep 13:115805. doi: 10.1016/j.bcp.2023.115805. Online ahead of print.ABSTRACTThe renin-angiotensin system (RAS) comprises a broad set of functional peptides and receptors that play a role in cardiovascular homeostasis and contribute to cardiovascular pathologies. Angiotensin II (Ang II) is the most potent peptide hormone produced by the RAS due to its high abundance and its strong and pleiotropic impact on the cardiovascular system. Formation of Ang II takes place in the bloodstream and additionally in tissues in the so-called local RAS. Of the two Ang II receptors (AT1 and AT2) that Ang II binds to...
Source: Biochemical Pharmacology - September 15, 2023 Category: Drugs & Pharmacology Authors: Andr é F Rodrigues Michael Bader Source Type: research
Corilagin alleviates LPS-induced sepsis through inhibiting pyroptosis via targeting TIR domain of MyD88 and binding CARD of ASC in macrophages
Biochem Pharmacol. 2023 Sep 13:115806. doi: 10.1016/j.bcp.2023.115806. Online ahead of print.ABSTRACTSepsis is a dysregulated systemic inflammatory response caused by infection that leads to multiple organ injury and high mortality without effective treatment. Corilagin, a natural polyphenol extracted from traditional Chinese herbs, exhibits strong anti-inflammatory properties. However, the role for Corilagin in lipopolysaccharide (LPS)-induced sepsis and the molecular mechanisms underlying this process have not been completely explored. Here we determine the effect of Corilagin on LPS-treated mice and use a screening appr...
Source: Biochemical Pharmacology - September 15, 2023 Category: Drugs & Pharmacology Authors: Senquan Wu Jia Liao Guodong Hu Liang Yan Xingyu Su Jiezhou Ye Chanjuan Zhang Tian Tian Huadong Wang Yiyang Wang Source Type: research
Statin as repurposed drug in Ovarian Cancer: A comprehensive review
Curr Pharm Des. 2023 Sep 13. doi: 10.2174/1381612829666230913113808. Online ahead of print.ABSTRACTWith a prevalence rate of 6.6 per 100,000 women, ovarian cancer is the third most lethal gynecological tumor in the world. Several factors like family history, nulliparity, late menopause, genetic mutation, and an unhealthy lifestyle contribute to increasing the risk of ovarian cancer development. Novel research studies suggest that ovarian cancer may be caused by changes in the lipid metabolic profile that trigger inflammatory responses. Moreover, ovarian cancer patients will eventually experience chemoresistance. Statin, a ...
Source: Current Pharmaceutical Design - September 15, 2023 Category: Drugs & Pharmacology Authors: Asmara Ahmad Sadia Javed Shumaila Kiran Source Type: research
MDMB-FUBINACA Influences Brain Angiogenesis and the Expression of VEGF, ANG-1, and ANG-2
CONCLUSION: MDMB-FUBINACA induces the progression of the angiogenesis process by inducing the expression of pro-angiogenic factors. These findings aim toward developing novel treatments for angiogenesis- related disorders.PMID:37711102 | DOI:10.2174/1570161121666230913093441
Source: Current Vascular Pharmacology - September 15, 2023 Category: Drugs & Pharmacology Authors: Laith Al-Eitan Mishael Alkhawaldeh Source Type: research
Salvia miltiorrhiza and Tanshinone IIA reduce endothelial inflammation and atherosclerotic plaque formation through inhibiting COX-2
Biomed Pharmacother. 2023 Sep 13;167:115501. doi: 10.1016/j.biopha.2023.115501. Online ahead of print.ABSTRACTThe mechanisms of Salvia miltiorrhiza (SM) and Tanshinone IIA (Tan IIA) in the treatment of atherosclerosis was examined by combining network pharmacology and molecular biology experiments. The TCMSP and BATMAN-TCM databases provided 104 SM candidate ingredients and 813 target genes, while GEO and GeneCards databases identified 35 overlapping targets between SM and coronary artery disease (CAD). From these data, we constructed a CAD-target-active ingredient network, and using Gene Ontology (GO) and KEGG pathway ana...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Xiangke Ma Lei Zhang Fujun Gao Weihua Jia Chao Li Source Type: research
Albumin nanoparticles and their folate modified counterparts for delivery of a lupine derivative to hepatocellular carcinoma
In conclusion, functionalized nanoparticles (FA-PEG-CTr-NPs) can specifically inhibit the malignant proliferation of HCC cells and are thus a promising nanoagent for the treatment of HCC.PMID:37713994 | DOI:10.1016/j.biopha.2023.115485
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Haohao Wang Di Wu Pan Wang Chunyu Gao Hongbo Teng Dong Liu Yan Zhao Rui Du Source Type: research
Activated MKK3/MYC crosstalk impairs dabrafenib response in BRAFV600E colorectal cancer leading to resistance
Biomed Pharmacother. 2023 Sep 13;167:115480. doi: 10.1016/j.biopha.2023.115480. Online ahead of print.ABSTRACTColorectal cancer (CRC) patients with BRAF mutations develop resistance to BRAF inhibitors at a very early stage. Understanding the molecular mechanisms involved in BRAF inhibitor resistance is critical for the development of novel therapeutic opportunities for this subtype of CRC patients. CRC cells bearing BRAF mutations are mostly sensitive to the abrogation of Mitogen-Activated Protein Kinase Kinase 3 (MKK3), a specific activator of p38MAPKs signaling, suggesting that BRAF alterations might addict CRC cells to ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Angelina Pranteda Valentina Piastra Martina Serra Roberta Bernardini Federica Lo Sardo Silvia Carpano Maria Grazia Diodoro Armando Bartolazzi Michele Milella Giovanni Blandino Gianluca Bossi Source Type: research
Why is There Still Debate About Recommending DPYD-Testing Before Fluoropyrimidine Treatment?
Clin Pharmacol Ther. 2023 Oct;114(4):733-737. doi: 10.1002/cpt.3016.NO ABSTRACTPMID:37713298 | DOI:10.1002/cpt.3016
Source: Clinical Pharmacology and Therapeutics - September 15, 2023 Category: Drugs & Pharmacology Authors: Ingolf Cascorbi Source Type: research
Highlights
Clin Pharmacol Ther. 2023 Oct;114(4):738-739. doi: 10.1002/cpt.3011.NO ABSTRACTPMID:37713297 | DOI:10.1002/cpt.3011
Source: Clinical Pharmacology and Therapeutics - September 15, 2023 Category: Drugs & Pharmacology Source Type: research
In this Issue
Clin Pharmacol Ther. 2023 Oct;114(4):731-732. doi: 10.1002/cpt.3013.NO ABSTRACTPMID:37713296 | DOI:10.1002/cpt.3013
Source: Clinical Pharmacology and Therapeutics - September 15, 2023 Category: Drugs & Pharmacology Source Type: research
Ascpt news
Clin Pharmacol Ther. 2023 Oct;114(4):740-744. doi: 10.1002/cpt.3014.NO ABSTRACTPMID:37713295 | DOI:10.1002/cpt.3014
Source: Clinical Pharmacology and Therapeutics - September 15, 2023 Category: Drugs & Pharmacology Source Type: research
Machine Learning: a New Approach for Dose Individualization
Clin Pharmacol Ther. 2023 Sep 15. doi: 10.1002/cpt.3049. Online ahead of print.ABSTRACTThe application of machine learning (ML) has shown promising results in precision medicine due to its exceptional performance in dealing with complex multidimensional data. However, using ML for individualized dosing of medicines is still in its early stage, meriting further exploration. A systematic review of study designs and modeling details of using ML for individualized dosing of different drugs was performed. We have summarized the status of the study populations, predictive targets, and data sources for ML modeling, the selection ...
Source: Clinical Pharmacology and Therapeutics - September 15, 2023 Category: Drugs & Pharmacology Authors: Qiu-Yue Li Bo-Hao Tang Yue-E Wu Bu-Fan Yao Wei Zhang Yi Zheng Yue Zhou John van den Anker Guo-Xiang Hao Wei Zhao Source Type: research
The effect of plasma exchange on serum levels of lacosamide: A case report
CONCLUSION: TPE appeared to remove an additional 20% of lacosamide when compared to the expected post-TPE concentration.PMID:37712141 | DOI:10.1093/ajhp/zxad224
Source: American Journal of Health-System Pharmacy : AJHP - September 15, 2023 Category: Drugs & Pharmacology Authors: Bradley J Peters Andrew E Brown Nathaniel M Thornton Jeffrey L Winters Sarah J Chalmers Source Type: research
Safety profile of nirmatrelvir-ritonavir: Evidence of adverse events due to drug-drug interactions
CONCLUSIONS: Our results show a high number of TDDIs detected were detected between NMV-r and other drugs. This study provides greater knowledge of the drugs involved in such interactions and their potential relationship with the occurrence of adverse events.PMID:37714801 | DOI:10.1016/j.farma.2023.08.005
Source: Farmacia Hospitalaria - September 15, 2023 Category: Drugs & Pharmacology Authors: Álvaro González-Gómez Jose Manuel Caro-Teller Iv án González-Barrios Almudena Castro-Fronti ñán Pedro Pablo Rodr íguez-Quesada Jos é Miguel Ferrari-Piquero Source Type: research
