Filtered By:
Source: Molecules
This page shows you your search results in order of date. This is page number 7.
Order by Relevance | Date
Total 981 results found since Jan 2013.
Molecules, Vol. 28, Pages 2074: Rhein & ndash;Amino Acid Ester Conjugates as Potential Antifungal Agents: Synthesis and Biological Evaluation
In this study, a series of rhein–amino acid ester conjugates were designed and synthesized in good yields, and their structures were confirmed by 1H-NMR, 13C-NMR and HRMS. The bioassay results revealed that most of the conjugates exhibited potent inhibitory activity against R. solani and S. sclerotiorum. In particular, conjugate 3c had the highest antifungal activity against R. solani with an EC50 value of 0.125 mM. For S. sclerotiorum, conjugate 3m showed the highest antifungal activity with an EC50 value of 0.114 mM. Satisfactorily, conjugate 3c exhibited better protective effects than that of the positive ...
Source: Molecules - February 22, 2023 Category: Chemistry Authors: Shunshun Chen Meimei Wang Linhua Yu Jinchao Shi Yong Zhang Yao Tian Li Li Xiang Zhu Junkai Li Tags: Article Source Type: research
Molecules, Vol. 28, Pages 2014: Proteomics Analysis of Lymphoblastoid Cell Lines from Patients with Amyotrophic Lateral Sclerosis
an Radu
Amyotrophic lateral sclerosis (ALS) consists of the progressive degeneration of motor neurons, caused by poorly understood mechanisms for which there is no cure. Some of the cellular perturbations associated with ALS can be detected in peripheral cells, including lymphocytes from blood. A related cell system that is very suitable for research consists of human lymphoblastoid cell lines (LCLs), which are immortalized lymphocytes. LCLs that can be easily expanded in culture and can be maintained for long periods as stable cultures. We investigated, on a small set of LCLs, if a proteomics analysis using liquid chr...
Source: Molecules - February 21, 2023 Category: Chemistry Authors: Danielle Whitham Eugene Belenkiy Costel C. Darie Aurelian Radu Tags: Article Source Type: research
Molecules, Vol. 28, Pages 1972: Anti-Cancer Effects of Queen Bee Acid (10-Hydroxy-2-Decenoic Acid) and Its Cellular Mechanisms against Human Hepatoma Cells
Conclusion: The current results confirmed the potent in vitro cytotoxic effects of 10-HDA on HepG2 cells with no significant cytotoxic effects on normal cells. Although its mechanisms of action have not been fully studied, the induction of apoptosis via different pathways was determined as one of the principle mechanisms of action of 10-HDA against HepG2 cells. Nevertheless, additional surveys must be performed to clearly understand the mechanisms of action and safety of this fatty acid.
Source: Molecules - February 19, 2023 Category: Chemistry Authors: Zafer Saad Al Shehri Abdullah D. Alanazi Sultan F. Alnomasy Tags: Article Source Type: research
Molecules, Vol. 28, Pages 1959: Recent Trends in the Development of Novel Metal-Based Antineoplastic Drugs
ova
Since the accidental discovery of the anticancer properties of cisplatin more than half a century ago, significant efforts by the broad scientific community have been and are currently being invested into the search for metal complexes with antitumor activity. Coordination compounds of transition metals such as platinum (Pt), ruthenium (Ru) and gold (Au) have proven their effectiveness as diagnostic and/or antiproliferative agents. In recent years, experimental work on the potential applications of elements including lanthanum (La) and the post-transition metal gallium (Ga) in the field of oncology has been gaining...
Source: Molecules - February 18, 2023 Category: Chemistry Authors: Lozan Todorov Irena Kostova Tags: Review Source Type: research
Molecules, Vol. 28, Pages 1955: Gallium(III)- and Indium(III)-Containing Ionic Liquids as Highly Active Catalysts in Organic Synthesis
ok
The chemical industry still requires development of environmentally friendly processes. Acid-catalysed chemical processes may cause environmental problems. Urgent need to replace conventional acids has forced the search for sustainable alternatives. Metal-containing ionic liquids have drawn considerable attention from scientists for many years. These compounds may exhibit very high Lewis acidity, which is usually dependent on the composition of the ionic liquid with the particular content of metal salt. Therefore, metal-containing ionic liquids have found a lot of applications and are successfully employed as cataly...
Source: Molecules - February 18, 2023 Category: Chemistry Authors: Justyna Wi ęcławik Anna Chrobok Tags: Review Source Type: research
Molecules, Vol. 28, Pages 1736: Tracking of Thermal, Physicochemical, and Biological Parameters of a Long-Term Stored Honey Artificially Adulterated with Sugar Syrups
Dżugan
The growing phenomenon of honey adulteration prompts the search for simple methods to confirm the authenticity of honey. The aim of the study was to evaluate the changes in thermal characteristics, physicochemical parameters, antioxidant and enzymatic activity of honey subjected to artificial adulteration. Two series of products were prepared with the use of two different sugar syrups with an increasing dosage of adulterant (0 to 30%). After 24 months of storage, the quality of adulterated samples (partially crystallized) was assessed in comparison to the control honey (solid). Used adulteration changed physico...
Source: Molecules - February 11, 2023 Category: Chemistry Authors: Monika Tomczyk Anna Czerniecka-Kubicka Micha ł Miłek Ewelina Sidor Ma łgorzata Dżugan Tags: Article Source Type: research
Molecules, Vol. 28, Pages 1690: The Structural Diversity and Biological Activity of Steroid Oximes
-Silva
Steroids and their derivatives have been the subject of extensive research among investigators due to their wide range of pharmacological properties, in which steroidal oximes are included. Oximes are a chemical group with the general formula R1R2C=N−OH and they exist as colorless crystals and are poorly soluble in water. Oximes can be easily obtained through the condensation of aldehydes or ketones with various amine derivatives, making them a very interesting chemical group in medicinal chemistry for the design of drugs as potential treatments for several diseases. In this review, we will focus o...
Source: Molecules - February 10, 2023 Category: Chemistry Authors: Ana R. Gomes Ana S. Pires Fernanda M. F. Roleira Elisi ário J. Tavares-da-Silva Tags: Review Source Type: research
Molecules, Vol. 28, Pages 1630: Study of Genotoxicity, Activities on Caspase 8 and on the Stabilization of the Topoisomerase Complex of Isoeleutherin and Analogues
This study evaluated the genotoxicity of Ethanol Extract (EEEp), Dichloromethane Fraction (FDCMEp) and isoeleutherin isolated from Eleutherine plicata, using the micronucleus test and the impact of structural alterations on toxicity and molecular docking (topoisomerase II and DNA complex). The extract was obtained by maceration and fractionation in a chromatography column. The genotoxicity was evaluated by the micronucleus test in human hepatoma cells (HepG2). Isoeleutherin was the starting molecule in the search for analogues by structural similarity, using the ZINC and e-Molecules databases. Isoeleutherin and analogues w...
Source: Molecules - February 8, 2023 Category: Chemistry Authors: Kelly Cristina Oliveira de Albuquerque Natasha Costa da Rocha Galucio Gleison Gon çalves Ferreira Ana Carolina Sousa Quaresma Valdicley Vieira Vale Marcelo de Oliveira Bahia Rommel Mario Rodriguez Burbano F ábio Alberto de Molfetta Sandro Percario Maria Tags: Article Source Type: research
Molecules, Vol. 28, Pages 1488: Antioxidant and Anti-Inflammatory Compounds from Edible Plants with Anti-Cancer Activity and Their Potential Use as Drugs
¡ndez
Food is our daily companion, performing numerous beneficial functions for our bodies. Many of them can help to alleviate or prevent ailments and diseases. In this review, an extensive bibliographic search is conducted in various databases to update information on unprocessed foods with anti-inflammatory and antioxidant properties that can aid in treating diseases such as cancer. The current state of knowledge on inflammatory processes involving some interleukins and tumor necrosis factor-alpha (TNF-α) is reviewed. As well as unprocessed foods, which may help reduce inflammation and oxidative stress,...
Source: Molecules - February 3, 2023 Category: Chemistry Authors: Sof Ãa Isabel Cuevas-Cianca Cristian Romero-Castillo Jos é Luis Gálvez-Romero Zaida Nelly Ju árez Luis Ricardo Hern ández Tags: Review Source Type: research
Molecules, Vol. 28, Pages 1394: Bio-Prospecting of Crude Leaf Extracts from Thirteen Plants of Brazilian Cerrado Biome on Human Glioma Cell Lines
Conclusion: These findings highlight M. chamissois chloroform partition as a promising component and may guide the search for the development of additional new anticancer therapies.
Source: Molecules - February 1, 2023 Category: Chemistry Authors: Silva Rosa Gomes Vital Alves Evangelista Longato Carloni Oliveira Pinto Rom ão Rezende Ara újo Oliveira Souza Oliveira Ribeiro Reis Tags: Article Source Type: research
Molecules, Vol. 28, Pages 1378: Stimulation of B-Lymphopoiesis by Administration of a Trimecaine-Based Ionic Compound in Cyclophosphamide-Induced Hematopoietic-Depressive Model
Khadichahan Rafikova
According to the WHO, the secondary form of hematopoietic-depressive status increases the risk of death in people with oncological, infectious, and hormonal diseases. The choice of drugs that stimulate the hematopoietic activity of B-lymphopoiesis is limited. The current leucopoiesis drugs have a number of side effects: thymic preparations stimulate the production of PGE2, which causes chronic inflammation and various autoimmune diseases through the differentiation of T helper 1 (Th1) cells, the proliferation of Th17 cells, and the production of IL-22 from Th22 cells through EP2 and EP4 receptor...
Source: Molecules - February 1, 2023 Category: Chemistry Authors: Layilya Baktybayeva Guldana Daulet Alexey Zazybin Valentina Yu Yekaterina Ostapchuk Yuliya Perfilyeva Aikyn Kali Nurshat Abdolla Aigul Malmakova Nuraly Baktybai Zhanerke Temirbekova Khadichahan Rafikova Tags: Article Source Type: research
Molecules, Vol. 28, Pages 1328: Screening of Active Ingredients from Wendan Decoction in Alleviating Palmitic Acid-Induced Endothelial Cell Injury
Conclusion: WDD has a protective effect on endothelial cell injury induced by palmitic acid, which may be related to its component content. This method was suitable for the search of active components in classical TCM.
Source: Molecules - January 30, 2023 Category: Chemistry Authors: Nan Xu Muhammad Ijaz Haiyan Shi Muhammad Shahbaz Meichao Cai Ping Wang Xiuli Guo Lei Ma Tags: Article Source Type: research
Molecules, Vol. 28, Pages 1240: Energy Level Prediction of Organic Semiconductors for Photodetectors and Mining of a Photovoltaic Database to Search for New Building Units
Mustafa Kamal
Due to the large versatility in organic semiconductors, selecting a suitable (organic semiconductor) material for photodetectors is a challenging task. Integrating computer science and artificial intelligence with conventional methods in optimization and material synthesis can guide experimental researchers to develop, design, predict and discover high-performance materials for photodetectors. To find high-performance organic semiconductor materials for photodetectors, it is crucial to establish a relationship between photovoltaic properties and chemical structures before performing synthetic procedures i...
Source: Molecules - January 27, 2023 Category: Chemistry Authors: Jehad Saleh Sajjad Haider Muhammad Saeed Akhtar Muhammad Saqib Muqadas Javed Sayed Elshahat Ghulam Mustafa Kamal Tags: Article Source Type: research
Molecules, Vol. 28, Pages 1252: Antimicrobial Activity of Quercetin, Naringenin and Catechin: Flavonoids Inhibit Staphylococcus aureus-Induced Hemolysis and Modify Membranes of Bacteria and Erythrocytes
lya B. Zavodnik
Search for novel antimicrobial agents, including plant-derived flavonoids, and evaluation of the mechanisms of their antibacterial activities are pivotal objectives. The goal of this study was to compare the antihemolytic activity of flavonoids, quercetin, naringenin and catechin against sheep erythrocyte lysis induced by α-hemolysin (αHL) produced by the Staphylococcus aureus strain NCTC 5655. We also sought to investigate the membrane-modifying action of the flavonoids. Lipophilic quercetin, but not naringenin or catechin, effectively inhibited the hemolytic activity of &am...
Source: Molecules - January 27, 2023 Category: Chemistry Authors: Artem G. Veiko Ewa Olchowik-Grabarek Szymon Sekowski Anna Roszkowska Elena A. Lapshina Izabela Dobrzynska Maria Zamaraeva Ilya B. Zavodnik Tags: Article Source Type: research
Molecules, Vol. 28, Pages 1176: Lavandula angustifolia Essential Oils as Effective Enhancers of Fluconazole Antifungal Activity against Candida albicans
ka
The increasing prevalence of Candida albicans resistance to commercial antifungal agents in recent decades has prompted modern medicine and veterinary medicine to search for combined treatment options. The aim of the study was to determine the activity of essential oils from different cultivars and morphological parts of the medicinal lavender (Lavandula angustifolia) in combination with fluconazole against Candida albicans ATCC 10231 strain. The effect of the combination of lavender essential oil with fluconazole was tested using the checkerboard method, and the obtained results were interpreted on the basis of fra...
Source: Molecules - January 25, 2023 Category: Chemistry Authors: Michalina Adaszy ńska-Skwirzyńska Ma łgorzata Dzięcioł Danuta Szczerbi ńska Tags: Article Source Type: research
