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Total 981 results found since Jan 2013.

Molecules, Vol. 27, Pages 5169: Marker Substances in the Aroma of Truffles
as Koch The aim of this study was to identify specific truffle marker substances within the truffle aroma. The aroma profile of different truffle species was analyzed using static headspace sampling with gas chromatography mass spectrometry analysis (SHS/GC-MS). Possible marker substances were identified, taking the additional literature into account. The selected marker substances were tested in an experiment with 19 truffle dogs. The hypothesis “If trained truffle dogs recognize the substances as supposed truffles in the context of an experiment, they can be regarded as specific” was made....
Source: Molecules - August 13, 2022 Category: Chemistry Authors: Ruben Epping Lilly Bliesener Tilman Weiss Matthias Koch Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5143: Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF- & kappa;B Signaling Cascade in RAW 264.7 Cells
This study exhibits the value of esculetin for the treatment of LTA-induced inflammation by targeting NF-κB signaling pathways via its antioxidant properties.
Source: Molecules - August 12, 2022 Category: Chemistry Authors: Thanasekaran Jayakumar Chun-Jen Huang Ting-Lin Yen Chih-Wei Hsia Joen-Rong Sheu Periyakali Saravana Bhavan Wei-Chieh Huang Cheng-Ying Hsieh Chih-Hsuan Hsia Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5150: Electrochemical Bottom-Up Synthesis of Chiral Carbon Dots from L-Proline and Their Application as Nano-Organocatalysts in a Stereoselective Aldol Reaction
izio Vetica Chirality is undoubtedly a fundamental property of nature since the different interactions of optically active molecules in a chiral environment are essential for numerous applications. Thus, in the field of asymmetric synthesis, the search for efficient, sustainable, cost-effective and recyclable chiral catalysts is still the main challenge in organic chemistry. The field of carbon dots (CDs) has experienced tremendous development in the last 15 years, including their applications as achiral catalysts. Thus, understanding the implications of chirality in CDs chemistry could be of utmost importance to achie...
Source: Molecules - August 12, 2022 Category: Chemistry Authors: Martina Bortolami Ingrid Izabela Bogles Cecilia Bombelli Fabiana Pandolfi Marta Feroci Fabrizio Vetica Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5128: Traditional Use, Phytochemical Profiles and Pharmacological Properties of Artemisia Genus from Central Asia
In conclusion, the examination of details between different Artemisia species in our research has shown that plant materials are good as an antioxidant and eznyme inhibitory functional natural source.
Source: Molecules - August 11, 2022 Category: Chemistry Authors: Aliya Nurlybekova Aidana Kudaibergen Aizhan Kazymbetova Magzhan Amangeldi Aizhamal Baiseitova Meirambek Ospanov Haji Akber Aisa Yang Ye Mohamed Ali Ibrahim Janar Jenis Tags: Article Source Type: research

Molecules, Vol. 27, Pages 5095: Natural Polyphenols as SERCA Activators: Role in the Endoplasmic Reticulum Stress-Related Diseases
ova Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) is a key protein responsible for transporting Ca2+ ions from the cytosol into the lumen of the sarco/endoplasmic reticulum (SR/ER), thus maintaining Ca2+ homeostasis within cells. Accumulating evidence suggests that impaired SERCA function is associated with disruption of intracellular Ca2+ homeostasis and induction of ER stress, leading to different chronic pathological conditions. Therefore, appropriate strategies to control Ca2+ homeostasis via modulation of either SERCA pump activity/expression or relevant signaling pathways may represent a useful approach to comb...
Source: Molecules - August 10, 2022 Category: Chemistry Authors: Jana Viskupicova Petronela Rezbarikova Tags: Review Source Type: research

Molecules, Vol. 27, Pages 5072: Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy
n Safi Yuan Seng Wu Rusli Nordin Mohammad Nazmul Hasan Maziz Vinoth Kumarasamy Pei Teng Lum Neeraj Kumar Fuloria Viniferin is a resveratrol derivative. Resveratrol is the most prominent stilbenoid synthesized by plants as a defense mechanism in response to microbial attack, toxins, infections or UV radiation. Different forms of viniferin exist, including alpha-viniferin (α-viniferin), beta-viniferin (β-viniferin), delta-viniferin (δ-viniferin), epsilon-viniferin (ε-viniferin), gamma-viniferin (γ-viniferin), R-viniferin (vitisin A), and R...
Source: Molecules - August 9, 2022 Category: Chemistry Authors: Shivkanya Fuloria Mahendran Sekar Farrah Syazana Khattulanuar Siew Hua Gan Nur Najihah Izzati Mat Rani Subban Ravi Vetriselvan Subramaniyan Srikanth Jeyabalan M. Yasmin Begum Kumarappan Chidambaram Kathiresan V. Sathasivam Sher Zaman Safi Yuan Seng Wu Rus Tags: Review Source Type: research

Molecules, Vol. 27, Pages 5045: Isolation and Characterization of Galloylglucoses Effective against Multidrug-Resistant Strains of Escherichia coli and Klebsiella pneumoniae
Holzgrabe The search for new antibiotics against multidrug-resistant (MDR), Gram-negative bacteria is crucial with respect to filling the antibiotics development pipeline, which is subject to a critical shortage of novel molecules. Screening of natural products is a promising approach for identifying antimicrobial compounds hosting a higher degree of novelty. Here, we report the isolation and characterization of four galloylglucoses active against different MDR strains of E. coli and K. pneumoniae. A crude acetone extract was prepared from Paeonia officinalis Linnaeus leaves, and bioautography-guided isolation of activ...
Source: Molecules - August 8, 2022 Category: Chemistry Authors: Nelson E. Masota Knut Ohlsen Curd Schollmayer Lorenz Meinel Ulrike Holzgrabe Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4978: Non-Invasive and Confirmatory Differentiation of Hermaphrodite from Both Male and Female Cannabis Plants Using a Hand-Held Raman Spectrometer
In this study, we investigate the potential of Raman spectroscopy (RS), an emerging sensing technique that can be used to probe plant biochemistry. Our results show that the biochemistry of male, female and hermaphroditic cannabis plants is drastically different which allows for their confirmatory identification using a hand-held Raman spectrometer. Furthermore, the coupling of machine learning approaches enables the identification of hermaphrodites with 98.7% accuracy, whereas both male and female plants can be identified with 100% accuracy. Considering the label-free, non-invasive and non-destructive nature of RS, the de...
Source: Molecules - August 5, 2022 Category: Chemistry Authors: Nicolas K. Goff James F. Guenther John K. Roberts Mickal Adler Michael Dalle Molle Greg Mathews Dmitry Kurouski Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4989: In Vitro Cytotoxic Activity of African Plants: A Review
a Pinho In African countries, cancer not only is a growing problem, but also a challenge because available funding and resources are limited. Therefore, African medicinal plants play a significant role in folk medicine and some of them are traditionally used for the treatment of cancer. The high mortality rate and adverse effects associated with cancer treatments have encouraged the search for novel plant-based drugs, thus, some African plants have been studied in recent years as a source of molecules with proven cytotoxicity. This review aims to discuss the cytotoxic activity, in vitro, of African plant crude extracts...
Source: Molecules - August 5, 2022 Category: Chemistry Authors: Isabel Canga Pedro Vita Ana Isabel Oliveira Mar ía Ángeles Castro Cl áudia Pinho Tags: Review Source Type: research

Molecules, Vol. 27, Pages 4961: Neuroprotection of Cannabidiol, Its Synthetic Derivatives and Combination Preparations against Microglia-Mediated Neuroinflammation in Neurological Disorders
Xian Zhou The lack of effective treatment for neurological disorders has encouraged the search for novel therapeutic strategies. Remarkably, neuroinflammation provoked by the activated microglia is emerging as an important therapeutic target for neurological dysfunction in the central nervous system. In the pathological context, the hyperactivation of microglia leads to neuroinflammation through the release of neurotoxic molecules, such as reactive oxygen species, proteinases, proinflammatory cytokines and chemokines. Cannabidiol (CBD) is a major pharmacologically active phytocannabinoids derived from Cannabis sativa L...
Source: Molecules - August 4, 2022 Category: Chemistry Authors: Muhammad Yousaf Dennis Chang Yang Liu Tianqing Liu Xian Zhou Tags: Review Source Type: research

Molecules, Vol. 27, Pages 4913: Improving the Enzymatic Cascade of Reactions for the Reduction of CO2 to CH3OH in Water: From Enzymes Immobilization Strategies to Cofactor Regeneration and Cofactor Suppression
detto The need to decrease the concentration of CO2 in the atmosphere has led to the search for strategies to reuse such molecule as a building block for chemicals and materials or a source of carbon for fuels. The enzymatic cascade of reactions that produce the reduction of CO2 to methanol seems to be a very attractive way of reusing CO2; however, it is still far away from a potential industrial application. In this review, a summary was made of all the advances that have been made in research on such a process, particularly on two salient points: enzyme immobilization and cofactor regeneration. A brief overview of th...
Source: Molecules - August 2, 2022 Category: Chemistry Authors: Carmela Di Spiridione Michele Aresta Angela Dibenedetto Tags: Review Source Type: research

Molecules, Vol. 27, Pages 4887: In Silico Screening of Quorum Sensing Inhibitor Candidates Obtained by Chemical Similarity Search
n Lee Quorum sensing (QS) is a bacterial communication using signal molecules, by which they sense population density of their own species, leading to group behavior such as biofilm formation and virulence. Autoinducer-2 (AI2) is a QS signal molecule universally used by both gram-positive and gram-negative bacteria. Inhibition of QS mediated by AI2 is important for various practical applications, including prevention of gum-disease caused by biofilm formation of oral bacteria. In this research, molecular docking and molecular dynamics (MD) simulations were performed for molecules that are chemically similar to known AI...
Source: Molecules - July 30, 2022 Category: Chemistry Authors: Sharath Belenahalli Shekarappa Hrvoje Rimac Julian Lee Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4861: Biofilm-i: A Platform for Predicting Biofilm Inhibitors Using Quantitative Structure & mdash;Relationship (QSAR) Based Regression Models to Curb Antibiotic Resistance
Molecules, Vol. 27, Pages 4861: Biofilm-i: A Platform for Predicting Biofilm Inhibitors Using Quantitative Structure—Relationship (QSAR) Based Regression Models to Curb Antibiotic Resistance Molecules doi: 10.3390/molecules27154861 Authors: Akanksha Rajput Kailash T. Bhamare Anamika Thakur Manoj Kumar Antibiotic drug resistance has emerged as a major public health threat globally. One of the leading causes of drug resistance is the colonization of microorganisms in biofilm mode. Hence, there is an urgent need to design novel and highly effective biofilm inhibitors that can work either synergisticall...
Source: Molecules - July 29, 2022 Category: Chemistry Authors: Akanksha Rajput Kailash T. Bhamare Anamika Thakur Manoj Kumar Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4739: Solanaceae Family Phytochemicals as Inhibitors of 3C-Like Protease of SARS-CoV-2: An In Silico Analysis
In this study, we have examined the binding energies of several alkaloids and anthocyanin derivatives from the Solanaceae family, a family which contains common consumable vegetables and fruit items such as eggplant, pepper, and tomatoes. Our study demonstrates that Solanaceae family alkaloids such as incanumine and solaradixine, as well as anthocyanins and anthocyanidins, have very high predicted binding energies for the 3C-like protease of SARS-CoV-2 (also known as Mpro). Since Mpro is vital for SARS-CoV-2 replication, the compounds merit potential for further antiviral research towards the objective of obtaining affordable drugs.
Source: Molecules - July 25, 2022 Category: Chemistry Authors: Raisul Awal Mahmood Anamul Hasan Mohammed Rahmatullah Alok K. Paul Rownak Jahan Khoshnur Jannat Tohmina Afroze Bondhon Tooba Mahboob Veeranoot Nissapatorn Maria de Lourdes Pereira Tridib K. Paul Ommay Hany Rumi Christophe Wiart Polrat Wilairatana Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4756: Peptide Biomarkers Discovery for Seven Species of Deer Antler Using LC-MS/MS and Label-Free Approach
In this study, we performed a comprehensive antler peptidome analysis using a label-free approach: nano LC-Orbitrap MS was applied to discover peptide biomarkers in deer adult beta-globin (HBBA), and HPLC-Triple Quadrupole MS was used to verify their specificity. Nineteen peptide biomarkers were found, on which foundation a strategy for antlers and a strategy for antler mixtures such as flakes or powder are provided to identify seven species of deer antler including Eurasian elk (Alces alces), reindeer (Rangifer tarandus), white-tailed deer (Odocoileus viginianus), white-lipped deer (Przewalskium albirostris), fallow deer ...
Source: Molecules - July 25, 2022 Category: Chemistry Authors: Fei Xue Bing Wang Dong-Xiao Guo Yang Jiao Xue Yin Wei-Liang Cui Qian-Qian Zhou Feng-Rui Yu Yong-Qiang Lin Tags: Article Source Type: research