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Total 981 results found since Jan 2013.

Molecules, Vol. 27, Pages 4669: Trends on CO2 Capture with Microalgae: A Bibliometric Analysis
A. Sáez The alarming levels of carbon dioxide (CO2) are an environmental problem that affects the economic growth of the world. CO2 emissions represent penalties and restrictions due to the high carbon footprint. Therefore, sustainable strategies are required to reduce the negative impact that occurs. Among the potential systems for CO2 capture are microalgae. These are defined as photosynthetic microorganisms that use CO2 and sunlight to obtain oxygen (O2) and generate value-added products such as biofuels, among others. Despite the advantages that microalgae may present, there are still technical–econo...
Source: Molecules - July 22, 2022 Category: Chemistry Authors: Alejandra M. Miranda Fabian Hernandez-Tenorio David Ocampo Gabriel J. Vargas Alex A. S áez Tags: Review Source Type: research

Molecules, Vol. 27, Pages 4505: Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators
In conclusion, Dalbergia tonkinensis is a valuable source of mono- and bifunctional, vasoactive scaffolds for the development of novel antihypertensive drugs.
Source: Molecules - July 14, 2022 Category: Chemistry Authors: Nguyen Manh Cuong Ninh The Son Ngu Truong Nhan Yoshiyasu Fukuyama Amer Ahmed Simona Saponara Alfonso Trezza Beatrice Gianibbi Ginevra Vigni Ottavia Spiga Fabio Fusi Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4491: Prenylated Flavonoids in Topical Infections and Wound Healing
lová The review presents prenylated flavonoids as potential therapeutic agents for the treatment of topical skin infections and wounds, as they can restore the balance in the wound microenvironment. A thorough two-stage search of scientific papers published between 2000 and 2022 was conducted, with independent assessment of results by two reviewers. The main criteria were an MIC (minimum inhibitory concentration) of up to 32 µg/mL, a microdilution/macrodilution broth method according to CLSI (Clinical and Laboratory Standards Institute) or EUCAST (European Committee on Antimicrobial Susceptibility Testin...
Source: Molecules - July 13, 2022 Category: Chemistry Authors: Alice Sychrov á Gabriela Škovranová Marie Čulenová Silvia Bittner Bittner Fialov á Tags: Review Source Type: research

Molecules, Vol. 27, Pages 4360: The Modulation of Melanogenesis in B16 Cells Upon Treatment with Plant Extracts and Isolated Plant Compounds
aw Zajdel Plants are a rich source of secondary metabolites that exhibit numerous desired properties. The compounds may influence the biology of melanocytes, pigment cells that produce melanin, by modulating numerous signaling pathways, including cAMP/PKA, MAPKs and PI3K/AKT. Its downstream target is microphthalmia-associated transcription factor, responsible for the expression of the tyrosinase enzyme, which plays a major role in melanogenesis. Therefore, this literature review aims to provide insights related to melanogenesis modulation mechanisms of plant extracts and isolated plant compounds in B16 cells. Database ...
Source: Molecules - July 7, 2022 Category: Chemistry Authors: Anna Merecz-Sadowska Przemys ław Sitarek Tomasz Kowalczyk Karolina Zajdel Ewa Kucharska Rados ław Zajdel Tags: Review Source Type: research

Molecules, Vol. 27, Pages 4282: Chemical Composition, Anti-Breast Cancer Activity and Extraction Techniques of Ent-Abietane Diterpenoids from Euphorbia fischeriana Steud
ng Yu Sun Ent-abietane diterpenoids are the main active constituents of Euphorbia fischeriana. In the continuing search for new anti-breast cancer drugs, 11 ent-abietane diterpenoids (1–11) were isolated from E. fischeriana. The structures of these compounds were clearly elucidated on the basis of 1D and 2D NMR spectra as well as HRESIMS data. Among them, compound 1 was a novel compound, compound 10 was isolated from Euphorbia genus for the first time, compound 11 was firstly discovered from E. fischeriana. These compounds exhibited varying degrees of growth inhibition against the MCF-10A, MCF-7, ZR-75-...
Source: Molecules - July 3, 2022 Category: Chemistry Authors: Gang Chen Tiancheng Ma Yukun Ma Cuicui Han Jinling Zhang Yu Sun Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4261: Amplified Spontaneous Emission Threshold Dependence on Determination Method in Dye-Doped Polymer and Lead Halide Perovskite Waveguides
ko Marco Anni Nowadays, the search for novel active materials for laser devices is proceeding faster and faster thanks to the development of innovative materials able to combine excellent stimulated emission properties with low-cost synthesis and processing techniques. In this context, amplified spontaneous emission (ASE) properties are typically investigated to characterize the potentiality of a novel material for lasers, and a low ASE threshold is used as the key parameter to select the best candidate. However, several different methods are currently used to define the ASE threshold, hindering meaningful comparison...
Source: Molecules - July 1, 2022 Category: Chemistry Authors: Stefania Milanese Maria Luisa De Giorgi Luis Cerd án Maria-Grazia La-Placa Nur Fadilah Jamaludin Annalisa Bruno Henk J. Bolink Maksym V. Kovalenko Marco Anni Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4251: The Chemical Composition and Biological Activities of Essential Oil from Korean Native Thyme Bak-Ri-Hyang (Thymus quinquecostatus Celak.)
In conclusion, this review will be helpful for utilizing the T. quinquecostatus plant in different industries including food, pharmaceuticals, pesticides, perfumery, and cosmetics.
Source: Molecules - July 1, 2022 Category: Chemistry Authors: Minju Kim Kandhasamy Sowndhararajan Songmun Kim Tags: Review Source Type: research

Molecules, Vol. 27, Pages 4240: Ziziphus nummularia: A Comprehensive Review of Its Phytochemical Constituents and Pharmacological Properties
Conclusion: Research into the phytochemical and pharmacological properties of Z. nummularia has demonstrated that this plant is a rich source of novel bioactive compounds. So far, Z. nummularia has shown a varied pharmacological profile (antioxidant, anticancer, anti-inflammatory, and cardioprotective), warranting further research to uncover the therapeutic potential of the bioactives of this plant. Taken together, Z. nummularia may represent a new potential target for the discovery of new drug leads.
Source: Molecules - June 30, 2022 Category: Chemistry Authors: Joelle Mesmar Rola Abdallah Adnan Badran Marc Maresca Abdullah Shaito Elias Baydoun Tags: Review Source Type: research

Molecules, Vol. 27, Pages 4213: Catalytic Performance of Immobilized Sulfuric Acid on Silica Gel for N-Formylation of Amines with Triethyl Orthoformate
rause In the search for convenient, green, and practical catalytic methods for the current interest in organic synthesis, a simple, green, and highly efficient protocol for N-formylation of various amines was carried out in the presence of immobilized sulfuric acid on silica gel (H2SO4–SiO2). All reactions were performed in refluxing triethyl orthoformate (65 °C). The product formamides were obtained with high-to-excellent yields within 4 min to 2 h. The current approach is advantageous, due to its short reaction time and high yields. The catalyst is recyclable with no significant loss in catalytic efficiency.
Source: Molecules - June 30, 2022 Category: Chemistry Authors: Sodeeq Aderotimi Salami Xavier Siwe-Noundou Rui W. M. Krause Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4210: In Silico Screening of Novel TMPRSS2 Inhibitors for Treatment of COVID-19
Wang COVID-19, a pandemic caused by the virus SARS-CoV-2, has spread globally, necessitating the search for antiviral compounds. Transmembrane protease serine 2 (TMPRSS2) is a cell surface protease that plays an essential role in SARS-CoV-2 infection. Therefore, researchers are searching for TMPRSS2 inhibitors that can be used for the treatment of COVID-19. As such, in this study, based on the crystal structure, we targeted the active site of TMPRSS2 for virtual screening of compounds in the FDA database. Then, we screened lumacaftor and ergotamine, which showed strong binding ability, using 100 ns molecular dynamics ...
Source: Molecules - June 30, 2022 Category: Chemistry Authors: Shuo Wang Xuexun Fang Ye Wang Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4141: Conversion of Natural Narciclasine to Its C-1 and C-6 Derivatives and Their Antitumor Activity Evaluation: Some Unusual Chemistry of Narciclasine
ko Tomas Hudlicky During the search for a general, efficient route toward the synthesis of C-1 analogues of narciclasine, natural narciclasine was protected and converted to its C-1 enol derivative using a novel semi-synthetic route. Attempted conversion of this material to its triflate in order to conduct cross-coupling at C-1 resulted in a triflate at C-6 that was successfully coupled with several functionalities. Four novel compounds were fully deprotected after seven steps and subjected to evaluation for cytotoxic activity against three cancer cell lines. Only one derivative showed moderate activity compared to t...
Source: Molecules - June 28, 2022 Category: Chemistry Authors: Juana Goulart Stollmaier Jared Thomson Mary Ann Endoma-Arias Razvan Simionescu Alexandra Vernaza Nakya Mesa-Diaz Mitchell Smith Liqin Du Alexander Kornienko Tomas Hudlicky Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4133: Screening an In-House Isoquinoline Alkaloids Library for New Blockers of Voltage-Gated Na+ Channels Using Voltage Sensor Fluorescent Probes: Hits and Biases
Daniel Henrion Pascal Richomme César Mattei Michel De Waard Anne-Marie Le Ray Christian Legros Voltage-gated Na+ (NaV) channels are significant therapeutic targets for the treatment of cardiac and neurological disorders, thus promoting the search for novel NaV channel ligands. With the objective of discovering new blockers of NaV channel ligands, we screened an In-House vegetal alkaloid library using fluorescence cell-based assays. We screened 62 isoquinoline alkaloids (IA) for their ability to decrease the FRET signal of voltage sensor probes (VSP), which were induced by the activation of NaV channels with ...
Source: Molecules - June 28, 2022 Category: Chemistry Authors: Quentin Coquerel Claire Legendre Jacinthe Frangieh Stephan De Waard J érôme Montnach Leos Cmarko Joseph Khoury Charifat Said Hassane Dimitri Br éard Benjamin Siegler Ziad Fajloun Harold De Pomyers Kamel Mabrouk Norbert Weiss Daniel Henrion Pascal Richo Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4118: A Computational Approach Applied to the Study of Potential Allosteric Inhibitors Protease NS2B/NS3 from Dengue Virus
o S. B. Brasil Dengue virus (DENV) is a danger to more than 400 million people in the world, and there is no specific treatment. Thus, there is an urgent need to develop an effective method to combat this pathology. NS2B/NS3 protease is an important biological target due it being necessary for viral replication and the fact that it promotes the spread of the infection. Thus, this study aimed to design DENV NS2B/NS3pro allosteric inhibitors from a matrix compound. The search was conducted using the Swiss Similarity tool. The compounds were subjected to molecular docking calculations, molecular dynamics simulations (MD) ...
Source: Molecules - June 27, 2022 Category: Chemistry Authors: Renato A. da Costa Jo ão A. P. da Rocha Alan S. Pinheiro Andr éia do S. S. da Costa Elaine C. M. da Rocha Rai. C. Silva Arlan da S. Gon çalves Cleydson B. R. Santos Davi do S. B. Brasil Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4091: The Classification of Rice Blast Resistant Seed Based on Ranman Spectroscopy and SVM
i Bo Ma Rice blast is a serious threat to rice yield. Breeding disease-resistant varieties is one of the most economical and effective ways to prevent damage from rice blast. The traditional identification of resistant rice seeds has some shortcoming, such as long possession time, high cost and complex operation. The purpose of this study was to develop an optimal prediction model for determining resistant rice seeds using Ranman spectroscopy. First, the support vector machine (SVM), BP neural network (BP) and probabilistic neural network (PNN) models were initially established on the original spectral data. Second, ...
Source: Molecules - June 25, 2022 Category: Chemistry Authors: Yan He Wei Zhang Yongcai Ma Jinyang Li Bo Ma Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4061: Should We & lsquo;Eat a Rainbow & rsquo;? An Umbrella Review of the Health Effects of Colorful Bioactive Pigments in Fruits and Vegetables
Molecules, Vol. 27, Pages 4061: Should We ‘Eat a Rainbow’? An Umbrella Review of the Health Effects of Colorful Bioactive Pigments in Fruits and Vegetables Molecules doi: 10.3390/molecules27134061 Authors: Michelle Blumfield Hannah Mayr Nienke De Vlieger Kylie Abbott Carlene Starck Flavia Fayet-Moore Skye Marshall Health promotion campaigns have advocated for individuals to ‘eat a rainbow’ of fruits and vegetables (FV). However, the literature has only focused on individual color pigments or individual health outcomes. This umbrella review synthesized the ...
Source: Molecules - June 24, 2022 Category: Chemistry Authors: Michelle Blumfield Hannah Mayr Nienke De Vlieger Kylie Abbott Carlene Starck Flavia Fayet-Moore Skye Marshall Tags: Review Source Type: research