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Total 981 results found since Jan 2013.

Molecules, Vol. 27, Pages 7274: Immunosuppressive Sesquiterpene Pyridine Alkaloids from Tripterygium wilfordii Hook. f
In this study, ten new SPAs, wilfordatine A–J (1–10), were isolated from the roots of T. wilfordii, along with ten known analogues (11–20). Their structures were primarily elucidated by extensive 1D and 2D NMR spectroscopic analysis. To search for more immunosuppressive ingredients related to the clinical efficacy of T. wilfordii, the total alkaloids (TA) and compounds 4, 5, and 9–16 were tested for their inhibitory effects on nuclear factor-kappa B (NF-κB) pathway in Lipopolysaccharide (LPS) induced HEK293/NF-κB-Luc cells. Among them, TA, ...
Source: Molecules - October 26, 2022 Category: Chemistry Authors: Yadan Wang Jiangong Yan Zhongmou Zhang Minghui Chen Xianfu Wu Shuangcheng Ma Tags: Article Source Type: research

Molecules, Vol. 27, Pages 7219: Synthesis of Novel Diketopyrrolopyrrole-Rhodamine Conjugates and Their Ability for Sensing Cu2+ and Li+
. Silva The search for accurate and sensitive methods to detect chemical substances, namely cations and anions, is urgent and widely sought due to the enormous impact that some of these chemical species have on human health and on the environment. Here, we present a new platform for the efficient sensing of Cu2+ and Li+ cations. For this purpose, two novel photoactive diketopyrrolopyrrole-rhodamine conjugates were synthesized through the condensation of a diketopyrrolopyrrole dicarbaldehyde with rhodamine B hydrazide. The resulting chemosensors 1 and 2, bearing one or two rhodamine hydrazide moieties, respectively, wer...
Source: Molecules - October 25, 2022 Category: Chemistry Authors: Carla Queir ós V ítor A. S. Almodôvar F ábio Martins Andreia Leite Augusto C. Tom é Ana M. G. Silva Tags: Article Source Type: research

Molecules, Vol. 27, Pages 7200: Biological Properties of Latex, Aqueous Extracts and Bee Products of Euphorbia officinarum L.: A Short Review
guel Euphorbia officinarum L. is a Moroccan endemic plant known as “Tikiout” and “Daghmus” that can also be found in Mauritania, Western Sahara, and Algeria. In the present review, “Euphorbia officinarum”, “metabolites” “hemisynthesis” were the keywords used for the research in the Web search engine Google Scholar and in the database Web of Science. Triterpenes, phytosterols and ingol diterpenes were isolated and identified in the latex of Moroccan E. officinarum. More than sixty t...
Source: Molecules - October 24, 2022 Category: Chemistry Authors: Oumaima Boutoub Lahsen El Ghadraoui Maria Gra ça Miguel Tags: Review Source Type: research

Molecules, Vol. 27, Pages 7109: Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of Myrtus communis against Staphylococcus Species
a D’Abrosca Myrtaceae family is a continuous source of antimicrobial agents. In the search for novel antimicrobial agents against Staphylococcus species, bioactive fractions of Myrtus communis L., growing in the Sardinia island (Italy) have been investigated. Their phytochemical analysis led us to isolate and characterize four alkylphloroglucinol glycosides (1–4), three of them gallomyrtucommulones G–H (1,2), and myrtucommulonoside (4) isolated and characterized for the first time. The structures of the new and known compounds, endopreroxide G3 (5), myricetin-3-O-glycosides (6,7) were dete...
Source: Molecules - October 21, 2022 Category: Chemistry Authors: Francesca Guzzo Alexandra G. Dur án Cinzia Sanna Rosangela Marasco Nicola Molfetta Elisabetta Buommino Antonio Fiorentino Brigida D ’Abrosca Tags: Article Source Type: research

Molecules, Vol. 27, Pages 7030: Evaluation of DNA-Damaging Effects Induced by Different Tanning Agents Used in the Processing of Natural Leather & mdash;Pilot Study on HepG2 Cell Line
Molecules, Vol. 27, Pages 7030: Evaluation of DNA-Damaging Effects Induced by Different Tanning Agents Used in the Processing of Natural Leather—Pilot Study on HepG2 Cell Line Molecules doi: 10.3390/molecules27207030 Authors: Sanja Ercegović Ražić Nevenka Kopjar Vilena Kašuba Zenun Skenderi Jadranka Akalović Jasna Hrenović For a long time, the production and processing of cowhide was based on the use of chrome tanning. However, the growing problem with chromium waste and its negative impact on human health and the environment prompted the search for more environmentally friendly processes ...
Source: Molecules - October 18, 2022 Category: Chemistry Authors: Sanja Ercegovi ć Ražić Nevenka Kopjar Vilena Ka šuba Zenun Skenderi Jadranka Akalovi ć Jasna Hrenovi ć Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6967: Metal Coordination Effects on the Photophysics of Dipyrrinato Photosensitizers
lliams Within this work, we review the metal coordination effect on the photophysics of metal dipyrrinato complexes. Dipyrrinato complexes are promising candidates in the search for alternative transition metal photosensitizers for application in photodynamic therapy (PDT). These complexes can be activated by irradiation with light of a specific wavelength, after which, cytotoxic reactive oxygen species (ROS) are generated. The metal coordination allows for the use of the heavy atom effect, which can enhance the triplet generation necessary for generation of ROS. Additionally, the flexibility of these complexes for met...
Source: Molecules - October 17, 2022 Category: Chemistry Authors: Paula C. P. Teeuwen Zoi Melissari Mathias O. Senge Rene ́ M. Williams Tags: Review Source Type: research

Molecules, Vol. 27, Pages 6940: A Literature Review of Artocarpus lacucha Focusing on the Phytochemical Constituents and Pharmacological Properties of the Plant
Conclusions: Mobe (A. lacucha) is a plant native to North Sumatra, Indonesia. This plant is efficacious as an antioxidant, antibacterial, antidiarrheal, anti-inflammatory, analgesic, antinociceptive, schistosomicidal, hepatoprotective, neuroprotective, cytotoxic, antiglycation, and anticholesterol, and can also be used for anti-aging and wound healing. In addition to its various benefits, it turns out that this plant also has many active compounds that are useful to the health sector, especially the pharmaceutical field.
Source: Molecules - October 16, 2022 Category: Chemistry Authors: Panal Sitorus Jane Melita Keliat Vivi Asfianti Mahatir Muhammad Denny Satria Tags: Review Source Type: research

Molecules, Vol. 27, Pages 6934: Potential Therapeutic Approach of Melatonin against Omicron and Some Other Variants of SARS-CoV-2
Yoshikazu Yonei The Omicron variant (B.529) of COVID-19 caused disease outbreaks worldwide because of its contagious and diverse mutations. To reduce these outbreaks, therapeutic drugs and adjuvant vaccines have been applied for the treatment of the disease. However, these drugs have not shown high efficacy in reducing COVID-19 severity, and even antiviral drugs have not shown to be effective. Researchers thus continue to search for an effective adjuvant therapy with a combination of drugs or vaccines to treat COVID-19 disease. We were motivated to consider melatonin as a defensive agent against SARS-CoV-2 because of...
Source: Molecules - October 16, 2022 Category: Chemistry Authors: Rahima Begum A. N. M. Mamun-Or-Rashid Tanzima Tarannum Lucy Md. Kamruzzaman Pramanik Bijon Kumar Sil Nobendu Mukerjee Priti Tagde Masayuki Yagi Yoshikazu Yonei Tags: Review Source Type: research

Molecules, Vol. 27, Pages 6889: Bis(oxiranes) Containing Cyclooctane Core: Synthesis and Reactivity towards NaN3
lena B. Averina Reactions of oxirane ring opening provide a powerful tool for regio- and stereoselective synthesis of polyfunctional and heterocyclic compounds, widely used in organic chemistry and drug design. Cyclooctane, alongside other medium-sized rings, is of interest as a novel molecular platform for the construction of target-oriented leads. Additionally, cyclooctane derivatives are well known to be prone to transannular reactions, which makes them a promising object in the search for novel approaches to polycyclic structures. In the present work, a series of cyclooctanediones was studied in Corey-Chaykovsky re...
Source: Molecules - October 14, 2022 Category: Chemistry Authors: Kseniya N. Sedenkova Olga V. Ryzhikova Svetlana A. Stepanova Alexei D. Averin Sergei V. Kositov Yuri K. Grishin Igor P. Gloriozov Elena B. Averina Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6847: The Use of Photodynamic Therapy in the Treatment of Brain Tumors & mdash;A Review of the Literature
Molecules, Vol. 27, Pages 6847: The Use of Photodynamic Therapy in the Treatment of Brain Tumors—A Review of the Literature Molecules doi: 10.3390/molecules27206847 Authors: Dorota Bartusik-Aebisher Aleksandra Żołyniak Edyta Barnaś Agnieszka Machorowska-Pieniążek Piotr Oleś Aleksandra Kawczyk-Krupka David Aebisher The treatment of neoplastic disease of the brain is still a challenge for modern medicine. Therefore, advanced methodologies are needed that can rationally and successfully contribute to the early diagnosis of primary and metastatic tumors growing within the brain. Photodynamic...
Source: Molecules - October 13, 2022 Category: Chemistry Authors: Dorota Bartusik-Aebisher Aleksandra Żołyniak Edyta Barna ś Agnieszka Machorowska-Pieni ążek Piotr Ole ś Aleksandra Kawczyk-Krupka David Aebisher Tags: Review Source Type: research

Molecules, Vol. 27, Pages 6860: Antimicrobial Activity of Silver and Gold Nanoparticles Prepared by Photoreduction Process with Leaves and Fruit Extracts of Plinia cauliflora and Punica granatum
Courrol The increased number of resistant microbes generates a search for new antibiotic methods. Metallic nanoparticles have emerged as a new platform against several microorganisms. The nanoparticles can damage the bacteria membrane and DNA by oxidative stress. The photoreduction process is a clean and low-cost method for obtaining silver and gold nanoparticles. This work describes two original insights: (1) the use of extracts of leaves and fruits from a Brazilian plant Plinia cauliflora, compared with a well know plant Punica granatum, and (2) the use of phytochemicals as stabilizing agents in the photoreduction pr...
Source: Molecules - October 13, 2022 Category: Chemistry Authors: Marcia Regina Franzolin Daniella dos Santos Courrol Flavia Rodrigues de Oliveira Silva Lilia Coronato Courrol Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6837: In Vitro Activity of Essential Oils Distilled from Colombian Plants against Candida auris and Other Candida Species with Different Antifungal Susceptibility Profiles
a-Arango Multi-drug resistant species such as Candida auris are a global health threat. This scenario has highlighted the need to search for antifungal alternatives. Essential oils (EOs), or some of their major compounds, could be a source of new antifungal molecules. The aim of this study was to evaluate the in vitro activity of EOs and some terpenes against C. auris and other Candida spp. The eleven EOs evaluated were obtained by hydro-distillation from different Colombian plants and the terpenes were purchased. EO chemical compositions were obtained by gas chromatography/mass spectrometry (GC/MS). Antifungal activit...
Source: Molecules - October 12, 2022 Category: Chemistry Authors: Carolina Zapata-Zapata Manuela Loaiza-Oliva Mar ía C. Martínez-Pabón Elena E. Stashenko Ana C. Mesa-Arango Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6768: Luminescent Carbon Dots from Wet Olive Pomace: Structural Insights, Photophysical Properties and Cytotoxicity
é V. Prata Carbon nanomaterials endowed with significant luminescence have been synthesized for the first time from an abundant, highly localized waste, the wet pomace (WP), a semi-solid by-product of industrial olive oil production. Synthetic efforts were undertaken to outshine the photoluminescence (PL) of carbon nanoparticles through a systematic search of the best reaction conditions to convert the waste biomass, mainly consisting in holocellulose, lignin and proteins, into carbon dots (CDs) by hydrothermal carbonization processes. Blue-emitting CDs with high fluorescence quantum yields were obtained. Using a comp...
Source: Molecules - October 10, 2022 Category: Chemistry Authors: Diogo A. Sousa Lu ís F. V. Ferreira Alexander A. Fedorov Ana M. B. do Rego Ana M. Ferraria Adriana B. Cruz M ário N. Berberan-Santos Jos é V. Prata Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6726: A Novel Two-Dimensional ZnSiP2 Monolayer as an Anode Material for K-Ion Batteries and NO2 Gas Sensing
ing Cheng Using the crystal-structure search technique and first-principles calculation, we report a new two-dimensional semiconductor, ZnSiP2, which was found to be stable by phonon, molecular-dynamic, and elastic-moduli simulations. ZnSiP2 has an indirect band gap of 1.79 eV and exhibits an anisotropic character mechanically. Here, we investigated the ZnSiP2 monolayer as an anode material for K-ion batteries and gas sensing for the adsorption of CO, CO2, SO2, NO, NO2, and NH3 gas molecules. Our calculations show that the ZnSiP2 monolayer possesses a theoretical capacity of 517 mAh/g for K ions and an ultralow diffusi...
Source: Molecules - October 9, 2022 Category: Chemistry Authors: Chunying Pu Zhuo Wang Xin Tang Dawei Zhou Jinbing Cheng Tags: Article Source Type: research

Molecules, Vol. 27, Pages 6712: Comparison of Odorants in Beef and Chicken Broth & mdash;Focus on Thiazoles and Thiazolines
Molecules, Vol. 27, Pages 6712: Comparison of Odorants in Beef and Chicken Broth—Focus on Thiazoles and Thiazolines Molecules doi: 10.3390/molecules27196712 Authors: Huiqi Yeo Dimitrios P. Balagiannis Jean H. Koek Jane K. Parker The shift in consumer landscape towards vegan, vegetarian and flexitarian diets has created an unprecedented challenge in creating meat aroma from plant-based alternatives. The search for potential vegan solutions has thus led to a renewed interest in authentic meat flavour profiles. To gain a better understanding of the qualitative odour differences between boiled beef and ...
Source: Molecules - October 9, 2022 Category: Chemistry Authors: Huiqi Yeo Dimitrios P. Balagiannis Jean H. Koek Jane K. Parker Tags: Article Source Type: research