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Association between weight loss agents and elevated liver enzymes: a population-based cross-sectional study
This study aimed to investigate the associations between weight loss agents and elevated liver enzymes at the population-level. We conducted a cross-sectional study using Korea National Health and Nutrition Examination Survey (KNHANES) data from 2013 to 2019. This study included 36,259 participants over 20 years of age who completed the questionnaire and had no history of hepatitis, cancer, or renal failure. In these participants, we analyzed associations between weight loss agents and elevated liver enzymes by constructing multiple logistic regression models with adjustment for confounding factors and stratified by sex, a...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ye-Jee Kim Seo Young Kang Mi-Sook Kim Joongyub Lee Bo Ram Yang Source Type: research

Regional disparities in suicide among patients with cancer: A nationwide population-based study in Japan
CONCLUSION: The results demonstrated that patients with cancer in certain prefectures in Japan have a high suicide risk.PMID:37737044 | DOI:10.1002/cam4.6574
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ken Kurisu Saki Harashima Maiko Fujimori Tatsuo Akechi Kazuhiro Yoshiuchi Yosuke Uchitomi Source Type: research

Fetal Exposure to Preeclampsia and Later Risk of Cardiometabolic Disorders: A Population-Based Cohort Study
CONCLUSIONS: Fetal preeclampsia exposure was associated with adult life hypertension, diabetes, and dyslipidemia, but these associations were likely due to shared etiological factors, rather than exposure to the preeclamptic condition itself.PMID:37737002 | DOI:10.1161/HYPERTENSIONAHA.122.20682
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Abira Paramsothy Tor-Arne Hegvik Anders Engeland Tone Bj ørge Grace M Egeland Kari Klungs øyr Source Type: research

Oncolytic virus oHSV2 combined with PD-1/PD-L1 inhibitors exert antitumor activity by mediating CD4  + T and CD8 + T cell infiltration in the lymphoma tumor microenvironment
Autoimmunity. 2023 Dec;56(1):2259126. doi: 10.1080/08916934.2023.2259126. Epub 2023 Sep 22.ABSTRACTA novel therapeutic regimen showed that the oncolytic type II herpes simplex virus (oHSV2) was able to prevent colorectal cancer growth, recurrence, and metastasis. However, no study has yet explored whether oHSV2 has an impact on the development of diffuse large B-cell lymphoma (DLBCL). We chose the clinical chemotherapeutic drug doxorubicin (DOX) as a positive control to evaluate the effect of oHSV2 infection on the apoptotic, invasive, and proliferative capacity of DLBCL cells. We next further explored the therapeutic effi...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jingbo Zhang Yiwei Guo Huiying Fang Xiuchen Guo Lina Zhao Source Type: research

Correction to: A comparison of two techniques of postoperative analgesia: lignocaine-fentanyl intravenous infusion and ropivacaine-fentanyl epidural infusion in patients undergoing cytoreductive cancer surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)-prospective randomized control study
Langenbecks Arch Surg. 2023 Sep 22;408(1):370. doi: 10.1007/s00423-023-03113-x.NO ABSTRACTPMID:37736776 | DOI:10.1007/s00423-023-03113-x
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Kiran Mahendru Rakesh Garg Sachidanand Jee Bharati Vinod Kumar Nishkarsh Gupta Seema Mishra Sushma Bhatnagar Mukurdipi Ray Suryanarayana Deo Source Type: research

Outcome of cancer patients after atrial fibrillation ablation: Insights from the China-AF registry
CONCLUSIONS: This study suggests that catheter ablation could be feasible for rhythm control of AF patients with concomitant cancer.PMID:37736690 | DOI:10.1111/pace.14830
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Xiaodong Peng Liu He Nian Liu Yanfei Ruan Xin Zhao Xueyuan Guo Wei Wang Songnan Li Ribo Tang Caihua Sang Chenxi Jiang Ronghui Yu Deyong Long Xin Du Jianzeng Dong Changsheng Ma Source Type: research

Argon-helium knife cryoablation plus programmed cell death protein 1 inhibitor in the treatment of advanced soft tissue sarcomas: there is no evidence of the synergistic effects of this combination therapy
CONCLUSION: Cryoablation combined with PD-1 inhibitors in the therapy of advanced STS is safe and can effectively shrink the cryoablation-target lesion. However, there is no evidence of the synergistic effects of this combination therapy.PMID:37736543 | PMC:PMC10509548 | DOI:10.3389/fonc.2023.1185291
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jiaqiang Wang Dengwei Zong Shuping Dong Shilei Gao Yonghao Yang Peng Zhang Xin Wang Weitao Yao Zhichao Tian Source Type: research

Evaluation of enhanced permeability effect and different linear energy transfer of radionuclides in a prostate cancer xenograft model
In conclusion, we found that specific targeting might negatively influence normal organ uptake when targeting secreted antigens. Furthermore, different energy deposition i.e. linear energy transfer of a radionuclide might have diverse effects on receptor expression and cell proliferation in tumors.PMID:37736493 | PMC:PMC10509292
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Oskar Vilhelmsson Timmermand Marcella Safi Bo Holmqvist Joanna Strand Source Type: research

Chemo-immune cell therapy by intratumoral injection of adoptive NK cells with capecitabine in gastric cancer xenograft model
CONCLUSION: Although NK cell therapy could effectively decrease the mitotic count in vivo, the obtained findings indicated lesser potency than MC despite ex vivo activation. In order to enhance NK cell therapy effectiveness, suppressive features of the tumor microenvironment and inhibitory immune checkpoints blockade should be considered.PMID:37736341 | PMC:PMC10509737 | DOI:10.34172/bi.2022.26386
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Zeinab Ghazvinian Shahrokh Abdolahi Mohammad Ahmadvand Amir Hossein Emami Samad Muhammadnejad Hamid Asadzadeh Aghdaei Jafar Ai Mohammad Reza Zali Iman Seyhoun Javad Verdi Kaveh Baghaei Source Type: research

Cytotoxicity of WT1-reactive T cells against Wilms tumor: An implication for antigen-specific adoptive immunotherapy
CONCLUSION: WT1-reactive T cells can be effectively enriched from the PBMCs of patients with Wilms tumor. Ex vivo generated WT1-reactive T cells might be considered an adoptive immunotherapeutic option for WT1+ Wilms tumors.PMID:37736339 | PMC:PMC10509739 | DOI:10.34172/bi.2023.27576
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Seyed Mostafa Monzavi Amir Ali Hamidieh Mohammad Vasei Jafar Ai Naser Ahmadbeigi Hamid Arshadi Samad Muhammadnejad Abdol-Mohammad Kajbafzadeh Source Type: research

Use of a Person-Centered Narrative Intervention in an Outpatient Palliative Care Setting: A Feasibility Study
J Patient Exp. 2023 Sep 18;10:23743735231202729. doi: 10.1177/23743735231202729. eCollection 2023.ABSTRACTPerson-centered narrative interventions offer potential solutions to facilitate a connection between the person receiving care and the person delivering the care, to improve quality of care, and positively impact a patient's biopsychosocial well-being. This single-arm feasibility study investigates patient-reported outcomes and barriers/facilitators to the implementation of an all-virtually delivered person-centered narrative intervention into the person's electronic health record. Overall, electronic data collection f...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Heather Coats Nadia Shive C Robert Bennett Bonnie Adrian Andrew D Boyd Ardith Z Doorenbos Sarah J Schmiege Source Type: research

Surgery As a Trigger for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Study
Conclusions Major surgery was a trigger for VTE, but the association between surgery and VTE risk was in part explained by other VTE triggers often coexisting with surgery, particularly immobilization and infection.PMID:37736074 | PMC:PMC10511275 | DOI:10.1055/a-2159-9957
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Dana Meknas Sigrid K Br ækkan John-Bjarne Hansen V ânia M Morelli Source Type: research

The diagnostic likelihood ratio function and modified test for trend: Identifying, evaluating, and validating nontraditional biomarkers in case-control studies
Stat Med. 2023 Sep 21. doi: 10.1002/sim.9912. Online ahead of print.ABSTRACTThe ROC curve and its associated summary statistic, the AUC, are used to identify informative diagnostic biomarkers under the assumption that risk of disease is a monotone function of the biomarker. We refer to biomarkers that meet this assumption as traditional, and those that do not as nontraditional. Nontraditional biomarkers most often arise when both low and high biomarker values are associated with an outcome of interest, such as blood pressure with medical complications or leukocyte count with ICU prognosis. Since nontraditional biomarkers d...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Hanna Lindner Phyllis A Gimotty Warren B Bilker Source Type: research

CT-Guided Percutaneous Cryoablation for Lung Metastasis of Colorectal Cancer: A Case Series
CONCLUSION: Lung CA is a safe and well-tolerated treatment with a satisfactory local control rate for patients with lung metastases derived from mCRC.PMID:37735896 | DOI:10.1177/15330338231201508
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Fu-Ming Wang Rong Luo Jin-Ming Tian Hang Liu Ji-Jin Yang Source Type: research

Establishing molecular pathology curriculum for pathology trainees and continued medical education: a collaborative work from the Molecular Pathology Study Group of the Korean Society of Pathologists
CONCLUSIONS: Approach toward the education of molecular pathology was refined, which would greatly benefit the future trainees.PMID:37735877 | DOI:10.4132/jptm.2023.08.26
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jiwon Koh Ha Young Park Jeong Mo Bae Jun Kang Uiju Cho Seung Eun Lee Haeyoun Kang Min Eui Hong Jae Kyung Won Youn-La Choi Wan-Seop Kim Ahwon Lee Source Type: research