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Paraneoplastic arthritis: a series of 92 cases
CONCLUSION: As a result, although PA is a rare condition, it can be confused with many rheumatological diseases. The most commonly involved joint is the knee joint, followed by the ankle and hand-wrist. Autoantibody negativity, high LDH level, and arthritis unresponsive to treatment constitute important clues for diagnosis.PMID:37738571 | DOI:10.1093/rheumatology/kead500
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: B ünyamin Kısacık Fatih Albayrak Mehmet Ali Balc ı Emrah Koc Source Type: research
Definitive carbon ion re-irradiation with pencil beam scanning in the treatment of unresectable locally recurrent rectal cancer
In conclusion, definitive carbon ion re-irradiation with PBS provided superior oncologic results with tolerable toxicities and may be served as a curative treatment strategy in unresectable LRRC.PMID:37738440 | DOI:10.1093/jrr/rrad068
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Xin Cai Ping Li Jingfang Zhao Weiwei Wang Jingyi Cheng Guangyuan Zhang Sanjun Cai Zhen Zhang Guoliang Jiang Qing Zhang Zheng Wang Source Type: research
Pregnancy and progression of differentiated thyroid cancer: A propensity score-matched retrospective cohort study
CONCLUSIONS: Pregnancy seemed to be irrelevant to DTC progression-free survival before surgical treatment. Further prospective cohort studies are needed to translate this finding into clinical practice.PMID:37738427 | DOI:10.1210/clinem/dgad557
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Wu-Cai Xiao Xin Li Rui Shan Fang Mei Shi-Bing Song Jing Chen Bang-Kai Sun Chun-Hui Yuan Zheng Liu Source Type: research
Effects of Photobiomodulation Therapy on Lung Function and Inflammatory Factors in Patients with COVID-19 During Acute Stage
Conclusions: Application of photobiomodulation is recommended for treatment of respiratory problems in patients with COVID-19 to improve clinical signs and control inflammatory factors. Clinical Trial Registration: IRCT2017070934969N1.PMID:37738370 | DOI:10.1089/photob.2022.0157
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Fatemeh Ehsani Rasool Bagheri Mahbubeh Darban Maral Hemati Mohammad Bahrami Fatemeh Sharafieh Source Type: research
Taxane-Based Chemotherapy Is Effective in Metastatic Appendiceal Adenocarcinoma
Oncologist. 2023 Sep 20:oyad263. doi: 10.1093/oncolo/oyad263. Online ahead of print.ABSTRACTAppendiceal cancer is a rare, orphan disease with no therapies currently approved by the FDA for its treatment. Given the limited data regarding drug efficacy, these tumors have historically been treated with chemotherapy designed for colon cancer. However, an overwhelming body of molecular data has demonstrated that appendiceal adenocarcinoma is a distinct entity with key molecular differences from colon cancer, notably rare APC mutation. Recognizing that APC loss-of-function is thought to contribute to taxane resistance and that t...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Julia Dansby Aditya More Mohammad Zeineddine Abdelrahman Yousef Alisha Bent Farshid Dayyani Robert Wolff Michael Overman John Paul Shen Source Type: research
ctDNA-guided adjuvant treatment after radical-intent treatment of metastatic spread from colorectal cancer-the first interim results from the OPTIMISE study
CONCLUSION: The study was proven to be feasible and continues in the planned large-scale phase II trial. Results from the OPTIMISE study will potentially optimize the adjuvant treatment of patients undergoing radical-intent treatment of mCRC, thereby improving survival and reducing chemotherapy-related toxicity.PMID:37738268 | DOI:10.1080/0284186X.2023.2259083
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Louise Bach Callesen Torben Fr østrup Hansen Rikke Fredslund Andersen Niels Pallisgaard Stine Kramer Sven Schlander S øren Rafael Rafaelsen Anders Kindberg Boysen Lars Henrik Jensen Anders Jakobsen Karen-Lise Garm Spindler Source Type: research
Recommendations on data sharing in HIV drug resistance research
PLoS Med. 2023 Sep 22;20(9):e1004293. doi: 10.1371/journal.pmed.1004293. Online ahead of print.ABSTRACTAuthor summary • Human immunodeficiency virus (HIV) drug resistance has implications for antiretroviral treatment strategies and for containing the HIV pandemic because the development of HIV drug resistance leads to the requirement for antiretroviral drugs that may be less effective, less well-tolerated, and more expensive than those used in first-line regimens. • HIV drug resistance studies are designed to determine which HIV mutations are selected by antiretroviral drugs and, in turn, how these mutations affect ant...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Seth C Inzaule Mark J Siedner Susan J Little Santiago Avila-Rios Alisen Ayitewala Ronald J Bosch Vincent Calvez Francesca Ceccherini-Silberstein Charlotte Charpentier Diane Descamps Susan H Eshleman Joseph Fokam Lisa M Frenkel Ravindra K Gupta John P A Io Source Type: research
Large-scale whole exome sequencing studies identify two genes,CTSL and APOE, associated with lung cancer
In this study, we investigate the contribution of rare variants (RVs) (minor allele frequency <0.01) to lung cancer through two large whole exome sequencing case-control studies. We first performed gene-based association tests using a novel Bayes Factor statistic in the International Lung Cancer Consortium, the discovery study (European, 1042 cases vs. 881 controls). The top genes identified are further assessed in the UK Biobank (European, 630 cases vs. 172 864 controls), the replication study. After controlling for the false discovery rate, we found two genes, CTSL and APOE, significantly associated with lung cancer i...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jingxiong Xu Wei Xu Jiyeon Choi Yonathan Brhane David C Christiani Jui Kothari James McKay John K Field Michael P A Davies Geoffrey Liu Christopher I Amos Rayjean J Hung Laurent Briollais Source Type: research
Decentralizing cancer care in sub-Saharan Africa through an integrated regional cancer centre model: The case of Kenya
This study aimed to analyze the status of the utilization of services at regional cancer centers. We analyzed data from the district health information system, focusing on patient demographics, visit type, cancer stage, and the type of treatment provided. For comparison, a trend analysis of new cancer cases recorded at the main national referral hospital between 2011-2021 was also conducted. We conducted a descriptive analysis of the variables of interest; the median was used to summarize continuous variables and percentages were used for categorical variables. A total of 29,321 patients visited the regional centers in 202...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Mary F Nyangasi Angela A McLigeyo David Kariuki Siwillis Mithe Albert Orwa Valerian Mwenda Source Type: research
Risk of thromboembolic events associated with different multiple myeloma regimens in Taiwan: a nested case-control study
J Thromb Thrombolysis. 2023 Sep 22. doi: 10.1007/s11239-023-02887-7. Online ahead of print.ABSTRACTAlthough novel agents for multiple myeloma (MM) have a better response rate and survival in both newly diagnosed and relapsed/refractory MM patients, concerns regarding the association between MM treatments and thromboembolic events have been raised. The aim of this population-based study was to examine the association between different combinations of MM treatments and the risk of thromboembolic events. We conducted a nested case-control study using the Taiwan Cancer Registry (TCR) and National Health Insurance Research Data...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Mei-Tsen Chen Shih-Tsung Huang Huai-Hsuan Huang Wen-Jone Chen Bor-Sheng Ko Fei-Yuan Hsiao Source Type: research
Rapid Detection of bla < sub > KPC < /sub > in Carbapenem-Resistant Enterobacterales Based on CRISPR/Cas13a
In conclusion, the RPA-Cas13a system is a simple and one-hour efficient technology for the detection of a potentially fatal antibiotic resistance gene.PMID:37737960 | DOI:10.1007/s00284-023-03457-z
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Mingjun Liang Bin Xiao Lidan Chen Xiaoyan Huang Jinchao Li Zhenzhan Kuang Xinping Chen Xiuna Huang Zhaohui Sun Linhai Li Source Type: research
The impact of intensified staging and combined therapies in locally advanced pancreatic cancer: a secondary analysis of prospective studies
CONCLUSIONS: The use of comprehensive pre-treatment staging, including laparoscopy and 18F-FDG-PET/CT scan, is an effective approach in identifying occult metastatic disease in LAPC patients. Our findings offer valuable insights into accurate staging and treatment efficacy, providing evidence-based support for optimal management strategies in LAPC patients.PMID:37737898 | DOI:10.1097/JS9.0000000000000755
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Michele Fiore Gian Marco Petrianni Pasquale Trecca Gabriele D'Ercole Alessandro Coppola Vincenzo La Vaccara Silvia Taralli Paola Cimini Carlo Greco Edy Ippolito Maria Lucia Calcagni Bruno Beomonte Zobel Damiano Caputo Roberto Coppola Sara Ramella Rolando Source Type: research
Harnessing Dendritic Cells: Next Frontier for Durable Immune Control in Myeloma
Clin Cancer Res. 2023 Sep 22:OF1-OF3. doi: 10.1158/1078-0432.CCR-23-2292. Online ahead of print.ABSTRACTImmune-based approaches including T-cell redirection have transformed the therapeutic landscape in myeloma. Injection of dendritic cells (DC) led to the induction of immune responses in vaccinated patients with myeloma. These studies pave the way for future combination strategies harnessing DCs to enhance tumor immunity and improve outcomes in myeloma. See related article by Freeman et al., p. 000.PMID:37737650 | DOI:10.1158/1078-0432.CCR-23-2292
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Madhav V Dhodapkar Source Type: research
Prevalence and predictors of colorectal cancer screening in the United States: evidence from the HINTS database 2018 to 2020
CONCLUSION: CRC screening rates among adults 45-49 years are low but are increasing steadily. Odds of CRC screening among Blacks is high which is encouraging while the odds among current smokers is low and concerning given their increased risk of developing CRC.PMID:37737304 | DOI:10.1007/s10552-023-01795-8
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Joseph Atarere Christopher Haas Ted Akhiwu Thilini Delungahawatta Ashik Pokharel Comfort Adewunmi Eugene Annor Vwaire Orhurhu Jasmine Barrow Source Type: research
Untargeted serum metabolomic profiles and breast density in young women
CONCLUSION: Our results suggest an inverse association of branched chain amino acids with %DBV. Larger studies in diverse populations are needed.PMID:37737303 | DOI:10.1007/s10552-023-01793-w
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Seungyoun Jung Sarah Silva Cher M Dallal Erin LeBlanc Kenneth Paris John Shepherd Linda G Snetselaar Linda Van Horn Yuji Zhang Joanne F Dorgan Source Type: research
