Challenges in Ventricular Arrhythmia Ablation: Difficult Substrates and Advanced Ablation Strategies
This article provides a brief overview of difficult substrate ablation strategies in patients with premature ventricular contractions (PVC) or ventricular tachycardia (VT) and explores methods to improve outcomes for cases that do not respond to typical ablation techniques.Recent findingsRecent developments highlight the crucial role of advanced imaging and mapping techniques in the visualization, characterization, and localization of challenging ventricular substrates. Additionally, some novel and advanced ablation strategies may be useful when PVC/VT is refractory to conventional ablation treatment.SummaryAn expanding sp...
Source: Current Treatment Options in Cardiovascular Medicine - April 25, 2024 Category: Cardiology Source Type: research

Understanding Cardiovascular Risk in Prostate Cancer: Role of Disparities, Diabetes, and Aging
AbstractPurpose of reviewThe primary objective of this review article is to dissect the intricate relationship between disparities, aging, diabetes, and their collective influence on cardiovascular disease (CVD) risk in prostate cancer (PC) patients. We sought to answer how these determinants interact with each other and contribute to the varying CVD outcomes observed in different subsets of PC patients.Recent findingsIt has become evident that social determinants of health (SDOH) significantly impact PC outcomes. Particularly, cardiovascular outcomes in non-Hispanic Black (NHB) patients, those from lower socioeconomic bac...
Source: Current Treatment Options in Cardiovascular Medicine - April 2, 2024 Category: Cardiology Source Type: research

Advanced Electroanatomic Mapping: Current and Emerging Approaches
AbstractPurpose of reviewContemporary ablation for complex arrhythmias raises several challenges for electroanatomic mapping. We examine how current and emerging systems may meet these challenges, and we outline major unmet needs.Recent findingsThe latest versions of the 3 major systems (Carto ™, Ensite X™, and Rhythmia™) all construct near real-time maps of cardiac anatomy, which can be registered to tomographic images that integrate thousands of electrical points from high-resolution catheters to create activation maps, and display voltage, proprietary features, and ablation lesio n locations. While these systems h...
Source: Current Treatment Options in Cardiovascular Medicine - February 27, 2024 Category: Cardiology Source Type: research

Mitigating Bias  in Clinical Machine Learning Models
AbstractPurpose of reviewIdentifying the risk for and addressing bias in clinical machine learning models is essential to reap its full benefits and ensure health equity. We provide a review of the machine learning landscape in clinical medicine, highlight ethical concerns with a particular focus on algorithmic bias, and offer a framework for mitigating bias.Recent findingsMachine learning, the computational framework that supports artificial intelligence, now plays a significant role in everyday life and its potential role in clinical medicine continues to increase exponentially. Multiple machine learning models have demo...
Source: Current Treatment Options in Cardiovascular Medicine - February 10, 2024 Category: Cardiology Source Type: research

Program Building in Cardio-oncology: Bridging Existing Care Gaps to Improve Cardiovascular and Cancer Outcomes
AbstractPurpose of the reviewWe aim to elaborate on the fundamentals of cardio-oncology-programs (COP) building, existing challenges, and future directions to expand access to COPs and improve outcomes.Recent findingsWorldwide, the number of COPs is growing. Strategic planning, qualified staff, well-equipped infrastructures, patient-centered focus, and academia are optimal elements for building and sustaining a COP. Alternative models leveraging existing resources are feasible for a larger number of institutions in the community and can achieve essential care metrics. Furthermore, advocacy, research, and education can play...
Source: Current Treatment Options in Cardiovascular Medicine - January 23, 2024 Category: Cardiology Source Type: research

The Use of Pre- and Peri-Procedural Imaging During VT Ablation
AbstractPurpose of reviewVentricular arrhythmias, including ventricular tachycardia (VT), ventricular fibrillation (VF), and premature ventricular complexes (PVCs), may occur in structurally normal hearts and in the context of structural heart disease. In those patients with recurrent arrhythmias despite medical therapy, catheter ablation may be considered. To successfully suppress ventricular arrhythmias, an understanding of the substrate for the arrhythmias is crucial.Recent findingsAdvances in cross-sectional imaging used prior to VT ablation permit accurate localisation of fibrosis that represents the substrate for VT,...
Source: Current Treatment Options in Cardiovascular Medicine - January 12, 2024 Category: Cardiology Source Type: research

Current Percutaneous Approaches to Treat Mitral Valve Regurgitation
AbstractPurpose of reviewIn recent years, our understanding of mitral regurgitation and its management has evolved substantially. In particular, as percutaneous mitral valve interventions have proven safe and effective, it has become possible to offer expanded therapeutic options to patients who are deemed inoperable or at high surgical risk. This review provides an overview of currently available transcatheter mitral valve interventions and summarizes recently published findings that may allow for better risk stratification, patient selection, and procedural safety and efficacy.Recent findingsIn the last 1 –2 years, nu...
Source: Current Treatment Options in Cardiovascular Medicine - January 3, 2024 Category: Cardiology Source Type: research

Moving Beyond Cardiotoxicity Detection to Prevention: A Pharmacologic Review
AbstractPurpose of reviewCardio-oncology is a subspecialty of medicine focused on minimizing the risk of cardiovascular (CV) toxicity in patients receiving potentially cardiotoxic cancer therapy. While the literature has previously focused on detection of CV toxicity, there has been growing interest in primary prevention strategies for cancer therapy-related cardiovascular toxicity (CTR-CVT).Recent findingsSeveral trials have investigated the role of angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and/or beta-blockers with mixed results, prompting researchers to assess alternatives, e....
Source: Current Treatment Options in Cardiovascular Medicine - January 2, 2024 Category: Cardiology Source Type: research