The Impact of the Chronic High-Altitude Environment on COPD Outcomes
Am J Respir Crit Care Med. 2024 Apr 24. doi: 10.1164/rccm.202404-0667ED. Online ahead of print.NO ABSTRACTPMID:38656771 | DOI:10.1164/rccm.202404-0667ED (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 24, 2024 Category: Intensive Care Authors: Brooks Thomas Kuhn Source Type: research

The Convoluted Journey to Unveil the Respiratory Syncytial Virus (RSV) in Chronic Obstructive Pulmonary Disease (COPD) Exacerbations: Old Paths and New Traces
Am J Respir Crit Care Med. 2024 Apr 24. doi: 10.1164/rccm.202403-0649ED. Online ahead of print.NO ABSTRACTPMID:38657157 | DOI:10.1164/rccm.202403-0649ED (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 24, 2024 Category: Intensive Care Authors: Federico Baraldi Marco Contoli Alberto Papi Source Type: research

Reply to Chi < em > et al. < /em > : Ventilator Waveforms May Give Clues to Expiratory Muscle Activity
Am J Respir Crit Care Med. 2024 Apr 24. doi: 10.1164/rccm.202402-0360LE. Online ahead of print.NO ABSTRACTPMID:38657264 | DOI:10.1164/rccm.202402-0360LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 24, 2024 Category: Intensive Care Authors: Glauco M Plens Eduardo L V Costa Giacomo Bellani Marcelo B P Amato Source Type: research

Ventilator Waveforms May Give Clues to Expiratory Muscle Activity
Am J Respir Crit Care Med. 2024 Apr 24. doi: 10.1164/rccm.202402-0269LE. Online ahead of print.NO ABSTRACTPMID:38657267 | DOI:10.1164/rccm.202402-0269LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 24, 2024 Category: Intensive Care Authors: Yi Chi Huaiwu He Yun Long Source Type: research

Human Airway and Alveolar Organoids from Bronchoalveolar Lavage Fluid
Am J Respir Crit Care Med. 2024 Apr 23. doi: 10.1164/rccm.202310-1831LE. Online ahead of print.NO ABSTRACTPMID:38652140 | DOI:10.1164/rccm.202310-1831LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 23, 2024 Category: Intensive Care Authors: Monica Yun Liu Belinda Chen Mehdi Borji Carolina Garcia de Alba Rivas Antonella F M Dost Aaron L Moye Nusrath Movval Abdulla Margherita Paschini Stuart D Rollins Ruobing Wang Lynn M Schnapp Hassan A Khalil Catherine J Wu Nirmal S Sharma Carla F Kim Source Type: research

Human Airway and Alveolar Organoids from Bronchoalveolar Lavage Fluid
Am J Respir Crit Care Med. 2024 Apr 23. doi: 10.1164/rccm.202310-1831LE. Online ahead of print.NO ABSTRACTPMID:38652140 | DOI:10.1164/rccm.202310-1831LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 23, 2024 Category: Intensive Care Authors: Monica Yun Liu Belinda Chen Mehdi Borji Carolina Garcia de Alba Rivas Antonella F M Dost Aaron L Moye Nusrath Movval Abdulla Margherita Paschini Stuart D Rollins Ruobing Wang Lynn M Schnapp Hassan A Khalil Catherine J Wu Nirmal S Sharma Carla F Kim Source Type: research

A Nanopore Sequencing-based Pharmacogenomic Panel to Personalize Tuberculosis Drug Dosing
CONCLUSION: Targeted sequencing can enable detection of polymorphisms influencing TB drug metabolism on a low-cost, portable instrument to personalize dosing for TB treatment or prevention. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38647526 | DOI:10.1164/rccm.202309-1583OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 22, 2024 Category: Intensive Care Authors: Renu Verma Kesia Esther da Silva Neesha Rockwood Roeland E Wasmann Nombuso Yende Taeksun Song Eugene Kim Paolo Denti Robert J Wilkinson Jason R Andrews Source Type: research

Another Step Closer to Genomic-informed Therapeutic Dosing for Tuberculosis Drugs
Am J Respir Crit Care Med. 2024 Apr 22. doi: 10.1164/rccm.202403-0566ED. Online ahead of print.NO ABSTRACTPMID:38648185 | DOI:10.1164/rccm.202403-0566ED (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 22, 2024 Category: Intensive Care Authors: Paul K Drain Source Type: research

Exhaled Volatile Organic Compounds for Asthma Control Classification in Children with Moderate to Severe Asthma: Results from the SysPharmPediA Study
CONCLUSIONS: Exhaled metabolites analysis might enable asthma control classification in children. This should stimulate further development of exhaled metabolites-based point-of-care tests in asthma.PMID:38648186 | DOI:10.1164/rccm.202312-2270OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 22, 2024 Category: Intensive Care Authors: Shahriyar Shahbazi Khamas Yoni Van Dijk Mahmoud I Abdel-Aziz Anne H Neerincx Jelle Blankestijn Susanne J H Vijverberg Simone Hashimoto Andrew Bush Aletta D Kraneveld Anna M Hedman Antoaneta A Toncheva Catarina Almqvist Christine Wolff Clare S Murray Gunil Source Type: research

Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic, Omalizumab, in Severe Asthma in Adults: Results of the SoMOSA Study
Conclusions This is the first discovery of omics biomarkers that predict improvement to a biologic for asthma. Their prospective validation and development for clinical use is justified.PMID:38635834 | DOI:10.1164/rccm.202310-1730OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 18, 2024 Category: Intensive Care Authors: Ratko Djukanovi ć Paul Brinkman Johan Kolmert Cristina Gomez James Schofield Joost Brandsma Andy Shapanis Paul J S Skipp Anthony Postle Craig Wheelock Sven-Erik Dahlen Peter J Sterk Thomas Brown David J Jackson Adel Mansur Ian Pavord Mitesh Patel Christo Source Type: research

Structural Lung Disease and Clinical Phenotype in Bronchiectasis Patients: The EMBARC CT Study
CONCLUSION: Patients with bronchiectasis have highly heterogeneous type and extent of structural lung abnormalities. Strong relationships between radiological disease and clinical features suggest CT analysis may be a useful tool for clinical phenotyping.PMID:38635862 | DOI:10.1164/rccm.202311-2109OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 18, 2024 Category: Intensive Care Authors: Angelina L P Pieters Tjeerd van der Veer Jennifer J Meerburg Eleni-Rosalina Andrinopoulou Menno M Vd Eerden Pierluigi Ciet Stefano Aliberti Pierre-Regis Burgel Megan L Crichton Amelia Shoemark Pieter C Goeminne Michal Shteinberg Michael R Loebinger Charle Source Type: research

Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic, Omalizumab, in Severe Asthma in Adults: Results of the SoMOSA Study
Conclusions This is the first discovery of omics biomarkers that predict improvement to a biologic for asthma. Their prospective validation and development for clinical use is justified.PMID:38635834 | DOI:10.1164/rccm.202310-1730OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 18, 2024 Category: Intensive Care Authors: Ratko Djukanovi ć Paul Brinkman Johan Kolmert Cristina Gomez James Schofield Joost Brandsma Andy Shapanis Paul J S Skipp Anthony Postle Craig Wheelock Sven-Erik Dahlen Peter J Sterk Thomas Brown David J Jackson Adel Mansur Ian Pavord Mitesh Patel Christo Source Type: research

Structural Lung Disease and Clinical Phenotype in Bronchiectasis Patients: The EMBARC CT Study
CONCLUSION: Patients with bronchiectasis have highly heterogeneous type and extent of structural lung abnormalities. Strong relationships between radiological disease and clinical features suggest CT analysis may be a useful tool for clinical phenotyping.PMID:38635862 | DOI:10.1164/rccm.202311-2109OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 18, 2024 Category: Intensive Care Authors: Angelina L P Pieters Tjeerd van der Veer Jennifer J Meerburg Eleni-Rosalina Andrinopoulou Menno M Vd Eerden Pierluigi Ciet Stefano Aliberti Pierre-Regis Burgel Megan L Crichton Amelia Shoemark Pieter C Goeminne Michal Shteinberg Michael R Loebinger Charle Source Type: research

Endobronchial Ultrasound-guided Cryobiopsy of Pulmonary Artery Intimal Sarcoma
Am J Respir Crit Care Med. 2024 Apr 17. doi: 10.1164/rccm.202309-1633IM. Online ahead of print.NO ABSTRACTPMID:38631018 | DOI:10.1164/rccm.202309-1633IM (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 17, 2024 Category: Intensive Care Authors: Simone Petrarulo Claudia Ravaglia Arianna Johanna De Grauw Stefano Oldani Suman Paul Alessandra Dubini Sara Piciucchi Venerino Poletti Source Type: research

Radiographic Outcomes in Paediatric Bronchiectasis and Factors Associated with Reversibility
CONCLUSIONS: This first large cohort confirms bronchiectasis in children is often reversible with appropriate management. Younger aged children and those with lesser radiographic severity at diagnosis were most likely to achieve radiographic reversibility whilst those with PsA infection were least likely.PMID:38631023 | DOI:10.1164/rccm.202402-0411OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 17, 2024 Category: Intensive Care Authors: Dustin R Mills Ian B Masters Stephanie T Yerkovich Jane McEniery Nitin Kapur Anne B Chang Julie M Marchant Vikas Goyal Source Type: research