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Optimizing Pharmacotherapy Management of COPD: Don't Miss the Forest for the Trees
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202402-0338VP. Online ahead of print.NO ABSTRACTPMID:38626371 | DOI:10.1164/rccm.202402-0338VP (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Jean Bourbeau Mohit Bhutani Paul Hernandez Erika Penz Darcy D Marciniuk Source Type: research

Transcriptome-Wide Association Study of Idiopathic Pulmonary Fibrosis Survival Identifies PTPN9 and SNRPB2 
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202310-1741LE. Online ahead of print.NO ABSTRACTPMID:38626378 | DOI:10.1164/rccm.202310-1741LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Xiaowei Hu John S Kim Aabida Saferali Yong Huang Shwu-Fan Ma Grace C Bingham Catherine A Bonham Carlos Flores Peter Castaldi Craig P Hersh Michael H Cho Imre Noth Ani Manichaikul IPF Survival GWAS Consortium Source Type: research

Plastic Bronchitis Related to Idiopathic Lymphatic Regurgitation
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202307-1246IM. Online ahead of print.NO ABSTRACTPMID:38625076 | DOI:10.1164/rccm.202307-1246IM (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Jiarui He Jun Li Huaping Dai Source Type: research

Quantitative CT in IPF: Is It Time to Act?
Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202403-0659ED. Online ahead of print.NO ABSTRACTPMID:38625082 | DOI:10.1164/rccm.202403-0659ED (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Lucio Calandriello Source Type: research

Disrupted BMP-9 Signaling Impairs Pulmonary Vascular Integrity in Hepatopulmonary Syndrome
CONCLUSION: The study findings suggest that portal hypertension-induced loss of BMP-9 signaling contributes to HPS development.PMID:38626313 | DOI:10.1164/rccm.202307-1289OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Fabien Robert Marie-Caroline Certain Audrey Baron Rapha ël Thuillet L éa Duhaut Mina Ottaviani Mustapha Kamel Chelgham Corinne Normand Nihel Berrebeh Nicolas Ricard Valerie Furlan Agn ès Desroches-Castan Emmanuel Gonzales Emmanuel Jacquemin Olivier Sit Source Type: research

Autoimmunity Against Surfactant Protein B Is Associated with Pneumonitis During Checkpoint Blockade
CONCLUSIONS: Our data suggest that the co-occurrence of surfactant protein-B-specific immunoglobulin G autoantibodies and CD4+ T cells is associated with the development of pneumonitis during ICI therapy. Pre-treatment levels of these antibodies may represent a potential biomarker for elevated risk of developing pneumonitis and on-treatment levels may provide a diagnostic aid.PMID:38626354 | DOI:10.1164/rccm.202311-2136OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Nina Wyss Fiamma Berner Vincent Walter Ann-Kristin Jochum Mette T Purde Marie-Therese Abdou Tobias Sinnberg Kathrin Hofmeister Oltin T Pop Omar Hasan Ali Jens Bauer Hung-Wei Cheng Mechthild L ütge Niklas Kl ümper Stefan Diem Zeynep Kosaloglu-Yalcin Yizh Source Type: research

Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis
CONCLUSIONS: WFDC2 dysfunction defines a novel molecular etiology of bronchiectasis characterized by the deficiency of a secreted component of the airways. A commercially available blood test combined with genetic testing allows its diagnosis. This article is open access and distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).PMID:38626355 | DOI:10.1164/rccm.202308-1370OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Gerard W Dougherty Lawrence E Ostrowski Tabea N öthe-Menchen Johanna Raidt Andre Schramm Heike Olbrich Weining Yin Patrick R Sears Hong Dang Amanda J Smith Achim G Beule Rim Hjeij Niels Rutjies Eric G Haarman Saskia M Maas Thomas W Ferkol Peadar G Noone Source Type: research

Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD
CONCLUSIONS: A novel multi-layer network analysis is able to identify clinically relevant COPD patient communities. Patients with similarly low FEV1 and emphysema can have molecularly distinct small airways and immune response patterns, indicating that different endotypes can lead to similar clinical presentation.PMID:38626356 | DOI:10.1164/rccm.202303-0500OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 16, 2024 Category: Intensive Care Authors: Nuria Olvera Jon S ánchez-Valle Iker N úñez-Carpintero Joselyn Rojas-Quintero Guillaume Noell Sandra Casas-Recasens Alen Faiz Philip Hansbro Angela Guirao Rosalba Lepore Davide Cirillo Alvar Agust í Francesca Polverino Alfonso Valencia Rosa Faner Source Type: research

Household Air Pollution Interventions to Improve Health in Low- and Middle-Income Countries: An Official American Thoracic Society Research Statement
Conclusions: HAP is associated with adverse health effects in observational studies. However, it remains unclear which household energy interventions reduce exposure, improve health, can be scaled, and are sustainable. Researchers should engage with policy makers and practitioners working to scale cleaner energy solutions to understand and address their information needs.PMID:38619436 | DOI:10.1164/rccm.202402-0398ST (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 15, 2024 Category: Intensive Care Authors: Peggy S Lai Nicholas L Lam Bill Gallery Alison G Lee Heather Adair-Rohani Donee Alexander Kalpana Balakrishnan Iwona Bisaga Zoe A Chafe Thomas Clasen Anait é Díaz-Artiga Andrew Grieshop Kat Harrison Stella M Hartinger Darby Jack Seyram Kaali Melissa Lyd Source Type: research

April 15 Highlight
Am J Respir Crit Care Med. 2024 Apr 15;209(8):xxvii-xxx. doi: 10.1164/rccm.209i8xxvii.NO ABSTRACTPMID:38619437 | DOI:10.1164/rccm.209i8xxvii (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 15, 2024 Category: Intensive Care Source Type: research

Erratum: A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities
Am J Respir Crit Care Med. 2024 Apr 15;209(8):1045. doi: 10.1164/rccm.v209erratum5.NO ABSTRACTPMID:38619438 | DOI:10.1164/rccm.v209erratum5 (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 15, 2024 Category: Intensive Care Source Type: research

Application of the ERS/ATS Spirometry Standards and Race-Neutral Equations in the COPDGene Study
CONCLUSIONS: The zGLI Global severity classification outperformed GOLD in the discrimination of survival, exacerbations, and imaging characteristics.PMID:38607551 | DOI:10.1164/rccm.202311-2145OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 12, 2024 Category: Intensive Care Authors: Enrico Schiavi Min Hyung Ryu Leonardo Martini Aparna Balasubramanian Meredith C McCormack Spyridon Fortis Elizabeth A Regan Matteo Bonini Craig P Hersh Source Type: research

Reply to Tiruvoipati et al. : VENT-AVOID Trial - Avoiding Acute Hypercapnic Respiratory Failure!
Am J Respir Crit Care Med. 2024 Apr 12. doi: 10.1164/rccm.202403-0618LE. Online ahead of print.NO ABSTRACTPMID:38608271 | DOI:10.1164/rccm.202403-0618LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - April 12, 2024 Category: Intensive Care Authors: Abhijit Duggal Steven A Conrad Laurent Brochard Daniel Brodie Nicholas S Hill Source Type: research