Longitudinal Lower Airway Microbial Signatures of Acute Cellular Rejection in Lung Transplantation
Conclusion: Dynamic changes in the lower airway microbiota are associated with the development of ACR, supporting its potential role as a useful biomarker or in ACR pathogenesis.PMID:38358857 | DOI:10.1164/rccm.202309-1551OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 15, 2024 Category: Intensive Care Authors: Jake G Natalini Kendrew K Wong Nathaniel C Nelson Benjamin G Wu Darya Rudym Melissa B Lesko Seema Qayum Tyler C Lewis Adrian Wong Stephanie H Chang Justin C Y Chan Travis C Geraci Yonghua Li Chan Wang Huilin Li Prerna Pamar Joseph Schnier Ian J Mahoney Ta Source Type: research

Shift-Level Team Familiarity Is Associated with Improved Outcomes in Mechanically Ventilated Adults
CONCLUSIONS: Interprofessional familiarity was associated with improved outcomes; assignment models that prioritize familiarity might be a novel solution.PMID:38358858 | DOI:10.1164/rccm.202310-1971OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 15, 2024 Category: Intensive Care Authors: Deena K Costa Olga Yakusheva Lara Khadr Hannah C Ratliff Kathryn A Lee Michael Sjoding Jose Victor Jimenez Deanna J Mariott Source Type: research

February 15 Highlight
Am J Respir Crit Care Med. 2024 Feb 15;209(4):xiiii-xiv. doi: 10.1164/rccm.209i4xiii.NO ABSTRACTPMID:38358127 | DOI:10.1164/rccm.209i4xiii (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 15, 2024 Category: Intensive Care Source Type: research

Erratum: Idiopathic Pulmonary Fibrosis Is Associated with Common Genetic Variants and Limited Rare Variants
Am J Respir Crit Care Med. 2024 Feb 15;209(4):462. doi: 10.1164/rccm.v209erratum2.NO ABSTRACTPMID:38358128 | DOI:10.1164/rccm.v209erratum2 (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 15, 2024 Category: Intensive Care Source Type: research

Early Diagnosis and Treatment of COPD: The Costs and Benefits of Case-Finding
Am J Respir Crit Care Med. 2024 Feb 15. doi: 10.1164/rccm.202311-2120PP. Online ahead of print.NO ABSTRACTPMID:38358788 | DOI:10.1164/rccm.202311-2120PP (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 15, 2024 Category: Intensive Care Authors: Shawn D Aaron Maria Montes de Oca Bartolome Celli Surya P Bhatt Jean Bourbeau Gerard J Criner Dawn L DeMeo David M G Halpin MeiLan K Han John R Hurst Jamuna K Krishnan David Mannino Job F M van Boven Claus F Vogelmeier Jadwiga A Wedzicha Barbara P Yawn Fe Source Type: research

Depths of Dysfunctional Epithelial and Immune Crosstalk in Cystic Fibrosis Revealed
Am J Respir Crit Care Med. 2024 Feb 15. doi: 10.1164/rccm.202401-0181ED. Online ahead of print.NO ABSTRACTPMID:38358817 | DOI:10.1164/rccm.202401-0181ED (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 15, 2024 Category: Intensive Care Authors: Lael M Yonker T Bernard Kinane Source Type: research

Unsung Heroes? De-Coding the Protective Effects of Airway Microbiota in COPD
Am J Respir Crit Care Med. 2024 Feb 15. doi: 10.1164/rccm.202401-0189ED. Online ahead of print.NO ABSTRACTPMID:38358821 | DOI:10.1164/rccm.202401-0189ED (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 15, 2024 Category: Intensive Care Authors: Miche ál Mac Aogáin Source Type: research

Funding Population-based Cohorts: Still Relevant for Respiratory Epidemiology in the Era of Big Data
Am J Respir Crit Care Med. 2024 Feb 15. doi: 10.1164/rccm.202401-0172ED. Online ahead of print.NO ABSTRACTPMID:38358824 | DOI:10.1164/rccm.202401-0172ED (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 15, 2024 Category: Intensive Care Authors: William Checkley John R Hurst Robert A Wise Source Type: research

Longitudinal Lower Airway Microbial Signatures of Acute Cellular Rejection in Lung Transplantation
Conclusion: Dynamic changes in the lower airway microbiota are associated with the development of ACR, supporting its potential role as a useful biomarker or in ACR pathogenesis.PMID:38358857 | DOI:10.1164/rccm.202309-1551OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 15, 2024 Category: Intensive Care Authors: Jake G Natalini Kendrew K Wong Nathaniel C Nelson Benjamin G Wu Darya Rudym Melissa B Lesko Seema Qayum Tyler C Lewis Adrian Wong Stephanie H Chang Justin C Y Chan Travis C Geraci Yonghua Li Chan Wang Huilin Li Prerna Pamar Joseph Schnier Ian J Mahoney Ta Source Type: research

Shift-Level Team Familiarity Is Associated with Improved Outcomes in Mechanically Ventilated Adults
CONCLUSIONS: Interprofessional familiarity was associated with improved outcomes; assignment models that prioritize familiarity might be a novel solution.PMID:38358858 | DOI:10.1164/rccm.202310-1971OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 15, 2024 Category: Intensive Care Authors: Deena K Costa Olga Yakusheva Lara Khadr Hannah C Ratliff Kathryn A Lee Michael Sjoding Jose Victor Jimenez Deanna J Mariott Source Type: research

Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis
CONCLUSIONS: Together, our findings show that altered lipid metabolism in sarcoidosis macrophages is associated with its predisposition to granuloma formation and suggest cholesterol-reducing therapies as a treatment option in patients.PMID:38353578 | DOI:10.1164/rccm.202307-1273OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 14, 2024 Category: Intensive Care Authors: Clarice X Lim Anna Redl Lisa Kleissl Ram Vinay Pandey Carolina Mayerhofer Thomas El Jammal Mario Mazic Karine Gonzales Nyamdelger Sukhbaatar Thomas Krausgruber Christoph Bock Markus Hengstschl äger Alain Calender Yves Pacheco Georg Stary Thomas Weichhart Source Type: research

Limiting Overdistention or Collapse when Mechanically Ventilating Injured Lungs: A Randomized Study in a Porcine Model
CONCLUSIONS: PEEP to minimize overdistention resulted in high mortality in an animal model of ARDS. Minimizing collapse or choosing a compromise between collapse and overdistention may result in less lung injury, with potential benefits of the compromise approach.PMID:38354065 | DOI:10.1164/rccm.202310-1895OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 14, 2024 Category: Intensive Care Authors: Mayson L A Sousa Bhushan H Katira Sheena Bouch Vanessa Hsing Doreen Engelberts Marcelo Amato Martin Post Laurent J Brochard Source Type: research

Zinpentraxin Alfa for Idiopathic Pulmonary Fibrosis: The Randomized Phase III STARSCAPE Trial
CONCLUSIONS: Zinpentraxin alfa treatment did not benefit patients with idiopathic pulmonary fibrosis over placebo. Learnings from this program may help improve decision-making around trials in idiopathic pulmonary fibrosis. Clinical trial registration available at www.CLINICALTRIALS: gov, ID: NCT04552899.PMID:38354066 | DOI:10.1164/rccm.202401-0116OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 14, 2024 Category: Intensive Care Authors: Luca Richeldi Courtney Schiffman J ürgen Behr Yoshikazu Inoue Tamera J Corte Vincent Cottin R Gisli Jenkins Steven D Nathan Ganesh Raghu Simon L F Walsh Parminderjit K Jayia Nikhil Kamath Fernando J Martinez Source Type: research

Monotherapy or Combination Therapy for Septic Shock? A Debate on Steroids
Am J Respir Crit Care Med. 2024 Feb 14. doi: 10.1164/rccm.202401-0175ED. Online ahead of print.NO ABSTRACTPMID:38354067 | DOI:10.1164/rccm.202401-0175ED (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 14, 2024 Category: Intensive Care Authors: Vasiliki Tsolaki Ilias I Siempos Source Type: research

Hierarchical CT Scoring Systems Cannot Discriminate Between Reversible Bronchiectasis and Mucus Plugs
Am J Respir Crit Care Med. 2024 Feb 14. doi: 10.1164/rccm.202311-2124LE. Online ahead of print.NO ABSTRACTPMID:38354402 | DOI:10.1164/rccm.202311-2124LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - February 14, 2024 Category: Intensive Care Authors: Ga ël Dournes Ilyes Benlala Source Type: research