HSPiP, Computational, and Thermodynamic Model-Based Optimized Solvents for Subcutaneous Delivery of Tolterodine Tartrate and GastroPlus-Based In Vivo Prediction in Humans: Part I
AAPS PharmSciTech. 2024 May 1;25(5):93. doi: 10.1208/s12249-024-02800-2.ABSTRACTTolterodine tartrate (TOTA) is associated with adverse effect, high hepatic access, varied bioavailability, slight aqueous solubility, and short half-life after oral delivery. Hansen solubility parameters (HSP, HSPiP program), experimental solubility (T = 298.2 to 318.2 K and p = 0.1 MPa), computational (van't Hoff and Apelblat models), and thermodynamic models were used to the select solvent(s). HSPiP predicted PEG400 as the most suitable co-solvent based on HSP values (δd = 17.88, δp = 4.0, and δh = 8.8 of PEG400) and comparable to the dru...
Source: AAPS PharmSciTech - May 1, 2024 Category: Drugs & Pharmacology Authors: Abdul Malik Tasneem Khan Mohd Usman Mohd Siddique Abdul Faruk Ashwani Kumar Sood Zahid Rafiq Bhat Source Type: research
HSPiP, Computational, and Thermodynamic Model-Based Optimized Solvents for Subcutaneous Delivery of Tolterodine Tartrate and GastroPlus-Based In Vivo Prediction in Humans: Part I
AAPS PharmSciTech. 2024 May 1;25(5):93. doi: 10.1208/s12249-024-02800-2.ABSTRACTTolterodine tartrate (TOTA) is associated with adverse effect, high hepatic access, varied bioavailability, slight aqueous solubility, and short half-life after oral delivery. Hansen solubility parameters (HSP, HSPiP program), experimental solubility (T = 298.2 to 318.2 K and p = 0.1 MPa), computational (van't Hoff and Apelblat models), and thermodynamic models were used to the select solvent(s). HSPiP predicted PEG400 as the most suitable co-solvent based on HSP values (δd = 17.88, δp = 4.0, and δh = 8.8 of PEG400) and comparable to the dru...
Source: AAPS PharmSciTech - May 1, 2024 Category: Drugs & Pharmacology Authors: Abdul Malik Tasneem Khan Mohd Usman Mohd Siddique Abdul Faruk Ashwani Kumar Sood Zahid Rafiq Bhat Source Type: research
HSPiP, Computational, and Thermodynamic Model-Based Optimized Solvents for Subcutaneous Delivery of Tolterodine Tartrate and GastroPlus-Based In Vivo Prediction in Humans: Part I
AAPS PharmSciTech. 2024 May 1;25(5):93. doi: 10.1208/s12249-024-02800-2.ABSTRACTTolterodine tartrate (TOTA) is associated with adverse effect, high hepatic access, varied bioavailability, slight aqueous solubility, and short half-life after oral delivery. Hansen solubility parameters (HSP, HSPiP program), experimental solubility (T = 298.2 to 318.2 K and p = 0.1 MPa), computational (van't Hoff and Apelblat models), and thermodynamic models were used to the select solvent(s). HSPiP predicted PEG400 as the most suitable co-solvent based on HSP values (δd = 17.88, δp = 4.0, and δh = 8.8 of PEG400) and comparable to the dru...
Source: AAPS PharmSciTech - May 1, 2024 Category: Drugs & Pharmacology Authors: Abdul Malik Tasneem Khan Mohd Usman Mohd Siddique Abdul Faruk Ashwani Kumar Sood Zahid Rafiq Bhat Source Type: research
HSPiP, Computational, and Thermodynamic Model-Based Optimized Solvents for Subcutaneous Delivery of Tolterodine Tartrate and GastroPlus-Based In Vivo Prediction in Humans: Part I
AAPS PharmSciTech. 2024 May 1;25(5):93. doi: 10.1208/s12249-024-02800-2.ABSTRACTTolterodine tartrate (TOTA) is associated with adverse effect, high hepatic access, varied bioavailability, slight aqueous solubility, and short half-life after oral delivery. Hansen solubility parameters (HSP, HSPiP program), experimental solubility (T = 298.2 to 318.2 K and p = 0.1 MPa), computational (van't Hoff and Apelblat models), and thermodynamic models were used to the select solvent(s). HSPiP predicted PEG400 as the most suitable co-solvent based on HSP values (δd = 17.88, δp = 4.0, and δh = 8.8 of PEG400) and comparable to the dru...
Source: AAPS PharmSciTech - May 1, 2024 Category: Drugs & Pharmacology Authors: Abdul Malik Tasneem Khan Mohd Usman Mohd Siddique Abdul Faruk Ashwani Kumar Sood Zahid Rafiq Bhat Source Type: research
Silk Fibroin Formed Bioadhesive Ophthalmic Gel for Dry Eye Syndrome Treatment
CONCLUSION: The CsA NBG formulation exhibits promising potential for intraocular drug delivery, enabling safe, effective, and controlled administration of hydrophobic drugs into the eye. Moreover, it enhances drug retention within the ocular tissues and improves systemic bioavailability, thereby demonstrating significant clinical translational prospects.PMID:38684590 | DOI:10.1208/s12249-024-02792-z (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - April 29, 2024 Category: Drugs & Pharmacology Authors: Tianjiao Hao Lu Tang Qianzi Xu Wei Wang Zengjing Li Yan Shen Bohui Xu Hao Luo Qian Li Jirong Wang Jinling Zhang Source Type: research
Silk Fibroin Formed Bioadhesive Ophthalmic Gel for Dry Eye Syndrome Treatment
CONCLUSION: The CsA NBG formulation exhibits promising potential for intraocular drug delivery, enabling safe, effective, and controlled administration of hydrophobic drugs into the eye. Moreover, it enhances drug retention within the ocular tissues and improves systemic bioavailability, thereby demonstrating significant clinical translational prospects.PMID:38684590 | DOI:10.1208/s12249-024-02792-z (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - April 29, 2024 Category: Drugs & Pharmacology Authors: Tianjiao Hao Lu Tang Qianzi Xu Wei Wang Zengjing Li Yan Shen Bohui Xu Hao Luo Qian Li Jirong Wang Jinling Zhang Source Type: research
Phospholipid Complex Formulation Technology for Improved Drug Delivery in Oncological Settings: a Comprehensive Review
This article provides a comprehensive exploration of the mechanisms underlying phospholipid complexes. Special emphasis is placed on the solvent evaporation method, with meticulous scrutiny of formulation aspects such as the phospholipid ratio to the drug and solvent. Characterization techniques are employed to understand structural and functional attributes. Highlighting the adaptability of the phospholipid complex, the review discusses the loading of various nanoformulations and emulsion systems. These strategies aim to enhance drug delivery and efficacy in various malignancies, including breast, liver, lung, cervical, a...
Source: AAPS PharmSciTech - April 25, 2024 Category: Drugs & Pharmacology Authors: Jayesh Patil Datta Maroti Pawde Sankha Bhattacharya Sauarbh Srivastava Source Type: research
Phospholipid Complex Formulation Technology for Improved Drug Delivery in Oncological Settings: a Comprehensive Review
This article provides a comprehensive exploration of the mechanisms underlying phospholipid complexes. Special emphasis is placed on the solvent evaporation method, with meticulous scrutiny of formulation aspects such as the phospholipid ratio to the drug and solvent. Characterization techniques are employed to understand structural and functional attributes. Highlighting the adaptability of the phospholipid complex, the review discusses the loading of various nanoformulations and emulsion systems. These strategies aim to enhance drug delivery and efficacy in various malignancies, including breast, liver, lung, cervical, a...
Source: AAPS PharmSciTech - April 25, 2024 Category: Drugs & Pharmacology Authors: Jayesh Patil Datta Maroti Pawde Sankha Bhattacharya Sauarbh Srivastava Source Type: research
Phospholipid Complex Formulation Technology for Improved Drug Delivery in Oncological Settings: a Comprehensive Review
This article provides a comprehensive exploration of the mechanisms underlying phospholipid complexes. Special emphasis is placed on the solvent evaporation method, with meticulous scrutiny of formulation aspects such as the phospholipid ratio to the drug and solvent. Characterization techniques are employed to understand structural and functional attributes. Highlighting the adaptability of the phospholipid complex, the review discusses the loading of various nanoformulations and emulsion systems. These strategies aim to enhance drug delivery and efficacy in various malignancies, including breast, liver, lung, cervical, a...
Source: AAPS PharmSciTech - April 25, 2024 Category: Drugs & Pharmacology Authors: Jayesh Patil Datta Maroti Pawde Sankha Bhattacharya Sauarbh Srivastava Source Type: research
Phospholipid Complex Formulation Technology for Improved Drug Delivery in Oncological Settings: a Comprehensive Review
This article provides a comprehensive exploration of the mechanisms underlying phospholipid complexes. Special emphasis is placed on the solvent evaporation method, with meticulous scrutiny of formulation aspects such as the phospholipid ratio to the drug and solvent. Characterization techniques are employed to understand structural and functional attributes. Highlighting the adaptability of the phospholipid complex, the review discusses the loading of various nanoformulations and emulsion systems. These strategies aim to enhance drug delivery and efficacy in various malignancies, including breast, liver, lung, cervical, a...
Source: AAPS PharmSciTech - April 25, 2024 Category: Drugs & Pharmacology Authors: Jayesh Patil Datta Maroti Pawde Sankha Bhattacharya Sauarbh Srivastava Source Type: research
QbD Based Formulation Development and Optimisation of Ozenoxacin Topical Nano-Emulgel and Efficacy Evaluation Using Impetigo Mice Model
This study demonstrates the application of QbD methodology for the development and optimization of an effective topical nanoemulgel formulation for the treatment of Impetigo focusing on the selection of appropriate excipients, optimization of formulation and process variables, and characterization of critical quality attributes. BBD was used to study the effect of "% of oil, % of Smix and homogenization speed" on critical quality attributes "globule size and % entrapment efficiency" for the optimisation of Ozenoxacin Nano-emulsion. Ozenoxacin loaded nano-emulgel was characterized for "description, identification, pH, speci...
Source: AAPS PharmSciTech - April 22, 2024 Category: Drugs & Pharmacology Authors: Amarnath Reddy Ramireddy Dilip Kumar Behara Source Type: research
QbD Based Formulation Development and Optimisation of Ozenoxacin Topical Nano-Emulgel and Efficacy Evaluation Using Impetigo Mice Model
This study demonstrates the application of QbD methodology for the development and optimization of an effective topical nanoemulgel formulation for the treatment of Impetigo focusing on the selection of appropriate excipients, optimization of formulation and process variables, and characterization of critical quality attributes. BBD was used to study the effect of "% of oil, % of Smix and homogenization speed" on critical quality attributes "globule size and % entrapment efficiency" for the optimisation of Ozenoxacin Nano-emulsion. Ozenoxacin loaded nano-emulgel was characterized for "description, identification, pH, speci...
Source: AAPS PharmSciTech - April 22, 2024 Category: Drugs & Pharmacology Authors: Amarnath Reddy Ramireddy Dilip Kumar Behara Source Type: research
QbD Based Formulation Development and Optimisation of Ozenoxacin Topical Nano-Emulgel and Efficacy Evaluation Using Impetigo Mice Model
This study demonstrates the application of QbD methodology for the development and optimization of an effective topical nanoemulgel formulation for the treatment of Impetigo focusing on the selection of appropriate excipients, optimization of formulation and process variables, and characterization of critical quality attributes. BBD was used to study the effect of "% of oil, % of Smix and homogenization speed" on critical quality attributes "globule size and % entrapment efficiency" for the optimisation of Ozenoxacin Nano-emulsion. Ozenoxacin loaded nano-emulgel was characterized for "description, identification, pH, speci...
Source: AAPS PharmSciTech - April 22, 2024 Category: Drugs & Pharmacology Authors: Amarnath Reddy Ramireddy Dilip Kumar Behara Source Type: research
Fluconazole-Loaded Ibuprofen In Situ Gel-Based Oral Spray for Oropharyngeal Candidiasis Treatment
AAPS PharmSciTech. 2024 Apr 19;25(5):89. doi: 10.1208/s12249-024-02804-y.ABSTRACTOral candidiasis is a fungal infection affecting the oral mucous membrane, and this research specifically addresses on a localized treatment through fluconazole-loaded ibuprofen in situ gel-based oral spray. The low solubility of ibuprofen is advantageous for forming a gel when exposed to an aqueous phase. The 1% w/w fluconazole-loaded in situ gel oral sprays were developed utilizing various concentrations of ibuprofen in N-methyl pyrrolidone. The prepared solutions underwent evaluation for viscosity, surface tension, contact angle, water tole...
Source: AAPS PharmSciTech - April 19, 2024 Category: Drugs & Pharmacology Authors: Ei Mon Khaing Setthapong Senarat Kritamorn Jitrangsri Thawatchai Phaechamud Source Type: research
A Comprehensive Analysis of Biopharmaceutical Products Listed in the FDA's Purple Book
This study did a comprehensive analysis of the FDA's Purple Book database. Firstly, our research uncovered market trends and provided insights into biologics distributions. According to the investigation, although biotechnology has advanced and legislative shifts have made the approval process faster, there are still challenges to overcome, such as molecular instability and formulation design. Moreover, our research comprehensively analyzed biological formulations, pointing out significant strategies regarding administration routes, dosage forms, product packaging, and excipients. In conjunction with biologics, the widespr...
Source: AAPS PharmSciTech - April 18, 2024 Category: Drugs & Pharmacology Authors: Fuduan Chen Hao Zhong Ging Chan Defang Ouyang Source Type: research
