Quality-by-Design Based Development of Doxycycline Hyclate-Loaded Polymeric Microspheres for Prolonged Drug Release
This study explores a novel approach to address the challenges of delivering highly water-soluble drug molecules by employing hydrophobic ion-pairing (HIP) complexes within poly (lactic-co-glycolic acid) (PLGA) microspheres. The HIP complex, formed between doxycycline hyclate (DH) and docusate sodium (DS), renders the drug hydrophobic. The development of the microspheres was done using the QbD approach, namely, Box-Behnken Design (BBD). A comprehensive characterization of the HIP complex confirmed the successful conversion of DH. DH and the HIP complex were effectively loaded into PLGA microspheres using the oil-in-water (...
Source: AAPS PharmSciTech - February 29, 2024 Category: Drugs & Pharmacology Authors: Suraj Longre Dhwani Rana Shagun Rangra Anil B Jindal Sagar Salave Jyotsna Vitore Derajram Benival Source Type: research
Nanocosmeceuticals: Trends and Recent Advancements in Self Care
AAPS PharmSciTech. 2024 Feb 29;25(3):51. doi: 10.1208/s12249-024-02761-6.ABSTRACTThe term cosmetics refers to any substances or products intended for external application on the skin with the aim of protection and better appearance of the skin surface. The skin delivery system promotes the controlled and targeted delivery of active ingredients. The development of this system has been driven by challenges encountered with conventional cosmeceuticals, including low skin retention of active components, limited percutaneous penetration, poor water dispersion of insoluble active ingredients, and instability of effective compone...
Source: AAPS PharmSciTech - February 29, 2024 Category: Drugs & Pharmacology Authors: Mitali Sethi Rafquat Rana Sharda Sambhakar Manish K Chourasia Source Type: research
Wurster Technology-Assisted Step-by-Step Engineering of Multi-layered Pellets (Sprinkles): Microscopy, Micro-CT, and e-Tongue-Based Analysis
AAPS PharmSciTech. 2024 Feb 29;25(3):50. doi: 10.1208/s12249-024-02773-2.ABSTRACTThe advancement in the formulation and characterization techniques have paved the path for development of new as well as modification of existing dosage forms. The present work explores the role of micro-computed tomography (micro-CT) as advanced characterization technique for multi-layered-coated pellets to ascertain the quality of coated pellets. The work further explored in-house e-tongue technique for understanding palatability of formulation in early stages of development thus by reducing clinical taste evaluation time. The developed mult...
Source: AAPS PharmSciTech - February 29, 2024 Category: Drugs & Pharmacology Authors: Vishnu Datta Maremanda Dirk Maertin Malak Bitar Abhijeet Pandey Source Type: research
Nanocarrier-Mediated Drug Delivery via Inhalational Route for Lung Cancer Therapy: A Systematic and Updated Review
AAPS PharmSciTech. 2024 Feb 29;25(3):47. doi: 10.1208/s12249-024-02758-1.ABSTRACTLung cancer is one of the most severe lethal malignancies, with approximately 1.6 million deaths every year. Lung cancer can be broadly categorised into small and non-small-cell lung cancer. The traditional chemotherapy is nonspecific, destroys healthy cells and produces systemic toxicity; targeted inhalation drug delivery in conjunction with nanoformulations has piqued interest as an approach for improving chemotherapeutic drug activity in the treatment of lung cancer. Our aim is to discuss the impact of polymer and lipid-based nanocarriers (...
Source: AAPS PharmSciTech - February 29, 2024 Category: Drugs & Pharmacology Authors: Nargis Ara Abdul Hafeez Source Type: research
Correction: Effects of Apex Size on Dissolution Profiles in the USP II Paddle Apparatus
AAPS PharmSciTech. 2024 Feb 29;25(3):48. doi: 10.1208/s12249-024-02770-5.NO ABSTRACTPMID:38424376 | DOI:10.1208/s12249-024-02770-5 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - February 29, 2024 Category: Drugs & Pharmacology Authors: Hiroyuki Yoshida Tokio Morita Yasuhiro Abe Aoi Inagaki Naomi Tomita Ken-Ichi Izutsu Yoji Sato Source Type: research
Quality-by-Design Based Development of Doxycycline Hyclate-Loaded Polymeric Microspheres for Prolonged Drug Release
This study explores a novel approach to address the challenges of delivering highly water-soluble drug molecules by employing hydrophobic ion-pairing (HIP) complexes within poly (lactic-co-glycolic acid) (PLGA) microspheres. The HIP complex, formed between doxycycline hyclate (DH) and docusate sodium (DS), renders the drug hydrophobic. The development of the microspheres was done using the QbD approach, namely, Box-Behnken Design (BBD). A comprehensive characterization of the HIP complex confirmed the successful conversion of DH. DH and the HIP complex were effectively loaded into PLGA microspheres using the oil-in-water (...
Source: AAPS PharmSciTech - February 29, 2024 Category: Drugs & Pharmacology Authors: Suraj Longre Dhwani Rana Shagun Rangra Anil B Jindal Sagar Salave Jyotsna Vitore Derajram Benival Source Type: research
Nanocosmeceuticals: Trends and Recent Advancements in Self Care
AAPS PharmSciTech. 2024 Feb 29;25(3):51. doi: 10.1208/s12249-024-02761-6.ABSTRACTThe term cosmetics refers to any substances or products intended for external application on the skin with the aim of protection and better appearance of the skin surface. The skin delivery system promotes the controlled and targeted delivery of active ingredients. The development of this system has been driven by challenges encountered with conventional cosmeceuticals, including low skin retention of active components, limited percutaneous penetration, poor water dispersion of insoluble active ingredients, and instability of effective compone...
Source: AAPS PharmSciTech - February 29, 2024 Category: Drugs & Pharmacology Authors: Mitali Sethi Rafquat Rana Sharda Sambhakar Manish K Chourasia Source Type: research
Cutaneous Pharmacokinetics of Topically Applied Novel Dermatological Formulations
This article serves as a valuable resource for researchers, scientists, and pharmaceutical professionals determined to enhance the development and understanding of novel dermatological drug products and the complex dynamics of cutaneous pharmacokinetics.PMID:38413430 | DOI:10.1208/s12249-024-02763-4 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - February 27, 2024 Category: Drugs & Pharmacology Authors: Meenakshi Patel Ashwini Patel Jagruti Desai Swayamprakash Patel Source Type: research
Cutaneous Pharmacokinetics of Topically Applied Novel Dermatological Formulations
This article serves as a valuable resource for researchers, scientists, and pharmaceutical professionals determined to enhance the development and understanding of novel dermatological drug products and the complex dynamics of cutaneous pharmacokinetics.PMID:38413430 | DOI:10.1208/s12249-024-02763-4 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - February 27, 2024 Category: Drugs & Pharmacology Authors: Meenakshi Patel Ashwini Patel Jagruti Desai Swayamprakash Patel Source Type: research
Cutaneous Pharmacokinetics of Topically Applied Novel Dermatological Formulations
This article serves as a valuable resource for researchers, scientists, and pharmaceutical professionals determined to enhance the development and understanding of novel dermatological drug products and the complex dynamics of cutaneous pharmacokinetics.PMID:38413430 | DOI:10.1208/s12249-024-02763-4 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - February 27, 2024 Category: Drugs & Pharmacology Authors: Meenakshi Patel Ashwini Patel Jagruti Desai Swayamprakash Patel Source Type: research
Using Dry Dispersion Laser Diffraction to Assess Dispersibility in Spheronized Agglomerate Formulations
In this study, dry dispersion laser diffraction was used to study the dispersibility of spheronized agglomerate formulations and identify geometric particle size metrics that correlated well with aerodynamic particle size distribution (APSD). Eleven unique batches of agglomerates were prepared for both laser diffraction and cascade impaction testing. Correlations between the particle size distribution (PSD) and aerodynamic particle size distribution (APSD) metrics for the eleven agglomerate batches were determined in a semi-empirical manner. The strongest correlation between APSD and PSD was observed between the impactor-s...
Source: AAPS PharmSciTech - February 23, 2024 Category: Drugs & Pharmacology Authors: Faustin Arevalo Steven Tignor Andrew Brunskill Adrian Goodey Source Type: research
Using Dry Dispersion Laser Diffraction to Assess Dispersibility in Spheronized Agglomerate Formulations
In this study, dry dispersion laser diffraction was used to study the dispersibility of spheronized agglomerate formulations and identify geometric particle size metrics that correlated well with aerodynamic particle size distribution (APSD). Eleven unique batches of agglomerates were prepared for both laser diffraction and cascade impaction testing. Correlations between the particle size distribution (PSD) and aerodynamic particle size distribution (APSD) metrics for the eleven agglomerate batches were determined in a semi-empirical manner. The strongest correlation between APSD and PSD was observed between the impactor-s...
Source: AAPS PharmSciTech - February 23, 2024 Category: Drugs & Pharmacology Authors: Faustin Arevalo Steven Tignor Andrew Brunskill Adrian Goodey Source Type: research
Using Dry Dispersion Laser Diffraction to Assess Dispersibility in Spheronized Agglomerate Formulations
In this study, dry dispersion laser diffraction was used to study the dispersibility of spheronized agglomerate formulations and identify geometric particle size metrics that correlated well with aerodynamic particle size distribution (APSD). Eleven unique batches of agglomerates were prepared for both laser diffraction and cascade impaction testing. Correlations between the particle size distribution (PSD) and aerodynamic particle size distribution (APSD) metrics for the eleven agglomerate batches were determined in a semi-empirical manner. The strongest correlation between APSD and PSD was observed between the impactor-s...
Source: AAPS PharmSciTech - February 23, 2024 Category: Drugs & Pharmacology Authors: Faustin Arevalo Steven Tignor Andrew Brunskill Adrian Goodey Source Type: research
Design of floating formulations and antiulcer activity of Desmostachya bipinnata
AAPS PharmSciTech. 2024 Feb 21;25(3):44. doi: 10.1208/s12249-024-02745-6.ABSTRACTThe study aims to design and optimize the floating formulations of the aqueous extract of Desmostachya bipinnata (ADB) to treat peptic ulcers. The trial concentrations of HPMC E50, HPMC K4M, and Carbopol 940 were used as factors, and floating lag time, total floating time, and % drug release at 12 h were used as responses. The formulation underwent evaluation for different parameters: aspirin-induced ulcers in rats assessed the antiulcer activity, and X-ray studies in rabbits evaluated the gastroretentive nature. The optimized formulation has ...
Source: AAPS PharmSciTech - February 22, 2024 Category: Drugs & Pharmacology Authors: Sanjay Kumar Putta Koteshwara Kb Usha Y Nayak Sreedhara Ranganath Pai K Raghuveer Pathuri Aswatha Ram Hn Source Type: research
Retraction Note: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation
AAPS PharmSciTech. 2024 Feb 21;25(3):43. doi: 10.1208/s12249-024-02768-z.NO ABSTRACTPMID:38383873 | DOI:10.1208/s12249-024-02768-z (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - February 22, 2024 Category: Drugs & Pharmacology Authors: Kifayat Ullah Khan Naveed Akhtar Muhammad Usman Minhas Source Type: research
