One Platform Comparison of Polymeric and Lipidic Nanoparticles for the Delivery of Amphotericin B
AAPS PharmSciTech. 2023 Nov 10;24(8):226. doi: 10.1208/s12249-023-02672-y.ABSTRACTAmphotericin B (AmB) is a membrane-acting antibiotic used for the treatment of fungal and protozoal infections. AmB exists in various molecular forms, i.e., monomeric, super-aggregated, and oligomeric forms, where oligomeric forms are highly toxic because of their relative affinity toward cholesterol present over human cell membrane. Hence, the objective of our research work was to study the aggregation state of AmB in two different nanoformulations, i.e., solid lipid nanoparticles (SLNs) and zein-based nanoparticles (PNPs), with the aim of e...
Source: AAPS PharmSciTech - November 9, 2023 Category: Drugs & Pharmacology Authors: Nandha Joyson Anchal Pathak Keerti Jain Source Type: research

ApoE3 Anchored Liposomal Delivery of Rivastigmine for Brain Delivery: Formulation, Characterization, and In Vivo Pharmacokinetic Evaluation
In this study, the RHT was incorporated inside the hydrophilic core of liposomes (LPS) and then coated with the ApoE3. ApoE3-coated RHT-loaded liposomes (ApoE3-RHT-LPS) were fabricated through the thin film hydration method using DSPE-PEG. The coating of LPS with ApoE3 enhances brain uptake and improves Aβ clearance. The results obtained from the physicochemical characterization demonstrated that ApoE3-RHT-LPS shows a particle size of 128.6 ± 2.16 nm and a zeta potential of 16.6 ± 1.19. The % entrapment efficiency and % drug loading were found to be 75% and 17.84%, respectively. The data obtained from TEM and SEM studie...
Source: AAPS PharmSciTech - November 9, 2023 Category: Drugs & Pharmacology Authors: Pooja Khairnar Ajit Singh Kailash Ahirwar Rahul Shukla Source Type: research

Investigations on Compaction Behavior of Kollidon < sup > ® < /sup > SR-Based Multi-component Directly Compressed Tablets for Preparation of Controlled Release Diclofenac Sodium
In conclusion, optimum quaternary tablets were obtained with optimum crushing strengths, relatively low Py, and moderate percentage porosities among all prepared quaternary tablets. The drug release of the optimum quaternary tablets demonstrated similar in vitro release profile compared to that of the marketed product with a mechanism of release that follows Korsmeyer-Peppas model.PMID:37945987 | DOI:10.1208/s12249-023-02685-7 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - November 9, 2023 Category: Drugs & Pharmacology Authors: Wasfy M Obeidat Ishraq K Lahlouh Shadi F Gharaibeh Source Type: research

Development of Sustained Release Formulations Based on Lipid-Liquid Crystal to Control the Release of Deoxycholate: In Vitro and In Vivo Assessment
AAPS PharmSciTech. 2023 Nov 10;24(8):224. doi: 10.1208/s12249-023-02677-7.ABSTRACTSubcutaneous injections of phosphatidylcholine (PC), sodium deoxycholate (NADC), and a mixture of them were found to be an effective option for treating cellulite. However, it is noteworthy that the injection of NADC may result in inflammation as well as necrosis in the injection area. The preparation of a sustained release formulation based on lipid-liquid crystal that controls the release of NADC could be a potential solution to address the issue of inflammation and necrosis at the site of injection. To present a practical and validated app...
Source: AAPS PharmSciTech - November 9, 2023 Category: Drugs & Pharmacology Authors: Maryam Kouhjani Arezoo Saberi Farzin Hadizadeh Elham Khodaverdi Malihe Karimi Elaheh Gholizadeh Hossein Kamali Ali Nokhodchi Source Type: research

One Platform Comparison of Polymeric and Lipidic Nanoparticles for the Delivery of Amphotericin B
AAPS PharmSciTech. 2023 Nov 10;24(8):226. doi: 10.1208/s12249-023-02672-y.ABSTRACTAmphotericin B (AmB) is a membrane-acting antibiotic used for the treatment of fungal and protozoal infections. AmB exists in various molecular forms, i.e., monomeric, super-aggregated, and oligomeric forms, where oligomeric forms are highly toxic because of their relative affinity toward cholesterol present over human cell membrane. Hence, the objective of our research work was to study the aggregation state of AmB in two different nanoformulations, i.e., solid lipid nanoparticles (SLNs) and zein-based nanoparticles (PNPs), with the aim of e...
Source: AAPS PharmSciTech - November 9, 2023 Category: Drugs & Pharmacology Authors: Nandha Joyson Anchal Pathak Keerti Jain Source Type: research

ApoE3 Anchored Liposomal Delivery of Rivastigmine for Brain Delivery: Formulation, Characterization, and In Vivo Pharmacokinetic Evaluation
In this study, the RHT was incorporated inside the hydrophilic core of liposomes (LPS) and then coated with the ApoE3. ApoE3-coated RHT-loaded liposomes (ApoE3-RHT-LPS) were fabricated through the thin film hydration method using DSPE-PEG. The coating of LPS with ApoE3 enhances brain uptake and improves Aβ clearance. The results obtained from the physicochemical characterization demonstrated that ApoE3-RHT-LPS shows a particle size of 128.6 ± 2.16 nm and a zeta potential of 16.6 ± 1.19. The % entrapment efficiency and % drug loading were found to be 75% and 17.84%, respectively. The data obtained from TEM and SEM studie...
Source: AAPS PharmSciTech - November 9, 2023 Category: Drugs & Pharmacology Authors: Pooja Khairnar Ajit Singh Kailash Ahirwar Rahul Shukla Source Type: research

Investigations on Compaction Behavior of Kollidon < sup > ® < /sup > SR-Based Multi-component Directly Compressed Tablets for Preparation of Controlled Release Diclofenac Sodium
In conclusion, optimum quaternary tablets were obtained with optimum crushing strengths, relatively low Py, and moderate percentage porosities among all prepared quaternary tablets. The drug release of the optimum quaternary tablets demonstrated similar in vitro release profile compared to that of the marketed product with a mechanism of release that follows Korsmeyer-Peppas model.PMID:37945987 | DOI:10.1208/s12249-023-02685-7 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - November 9, 2023 Category: Drugs & Pharmacology Authors: Wasfy M Obeidat Ishraq K Lahlouh Shadi F Gharaibeh Source Type: research

Development of Sustained Release Formulations Based on Lipid-Liquid Crystal to Control the Release of Deoxycholate: In Vitro and In Vivo Assessment
AAPS PharmSciTech. 2023 Nov 10;24(8):224. doi: 10.1208/s12249-023-02677-7.ABSTRACTSubcutaneous injections of phosphatidylcholine (PC), sodium deoxycholate (NADC), and a mixture of them were found to be an effective option for treating cellulite. However, it is noteworthy that the injection of NADC may result in inflammation as well as necrosis in the injection area. The preparation of a sustained release formulation based on lipid-liquid crystal that controls the release of NADC could be a potential solution to address the issue of inflammation and necrosis at the site of injection. To present a practical and validated app...
Source: AAPS PharmSciTech - November 9, 2023 Category: Drugs & Pharmacology Authors: Maryam Kouhjani Arezoo Saberi Farzin Hadizadeh Elham Khodaverdi Malihe Karimi Elaheh Gholizadeh Hossein Kamali Ali Nokhodchi Source Type: research

One Platform Comparison of Polymeric and Lipidic Nanoparticles for the Delivery of Amphotericin B
AAPS PharmSciTech. 2023 Nov 10;24(8):226. doi: 10.1208/s12249-023-02672-y.ABSTRACTAmphotericin B (AmB) is a membrane-acting antibiotic used for the treatment of fungal and protozoal infections. AmB exists in various molecular forms, i.e., monomeric, super-aggregated, and oligomeric forms, where oligomeric forms are highly toxic because of their relative affinity toward cholesterol present over human cell membrane. Hence, the objective of our research work was to study the aggregation state of AmB in two different nanoformulations, i.e., solid lipid nanoparticles (SLNs) and zein-based nanoparticles (PNPs), with the aim of e...
Source: AAPS PharmSciTech - November 9, 2023 Category: Drugs & Pharmacology Authors: Nandha Joyson Anchal Pathak Keerti Jain Source Type: research

ApoE3 Anchored Liposomal Delivery of Rivastigmine for Brain Delivery: Formulation, Characterization, and In Vivo Pharmacokinetic Evaluation
In this study, the RHT was incorporated inside the hydrophilic core of liposomes (LPS) and then coated with the ApoE3. ApoE3-coated RHT-loaded liposomes (ApoE3-RHT-LPS) were fabricated through the thin film hydration method using DSPE-PEG. The coating of LPS with ApoE3 enhances brain uptake and improves Aβ clearance. The results obtained from the physicochemical characterization demonstrated that ApoE3-RHT-LPS shows a particle size of 128.6 ± 2.16 nm and a zeta potential of 16.6 ± 1.19. The % entrapment efficiency and % drug loading were found to be 75% and 17.84%, respectively. The data obtained from TEM and SEM studie...
Source: AAPS PharmSciTech - November 9, 2023 Category: Drugs & Pharmacology Authors: Pooja Khairnar Ajit Singh Kailash Ahirwar Rahul Shukla Source Type: research

Investigations on Compaction Behavior of Kollidon < sup > ® < /sup > SR-Based Multi-component Directly Compressed Tablets for Preparation of Controlled Release Diclofenac Sodium
In conclusion, optimum quaternary tablets were obtained with optimum crushing strengths, relatively low Py, and moderate percentage porosities among all prepared quaternary tablets. The drug release of the optimum quaternary tablets demonstrated similar in vitro release profile compared to that of the marketed product with a mechanism of release that follows Korsmeyer-Peppas model.PMID:37945987 | DOI:10.1208/s12249-023-02685-7 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - November 9, 2023 Category: Drugs & Pharmacology Authors: Wasfy M Obeidat Ishraq K Lahlouh Shadi F Gharaibeh Source Type: research

Development of Sustained Release Formulations Based on Lipid-Liquid Crystal to Control the Release of Deoxycholate: In Vitro and In Vivo Assessment
AAPS PharmSciTech. 2023 Nov 10;24(8):224. doi: 10.1208/s12249-023-02677-7.ABSTRACTSubcutaneous injections of phosphatidylcholine (PC), sodium deoxycholate (NADC), and a mixture of them were found to be an effective option for treating cellulite. However, it is noteworthy that the injection of NADC may result in inflammation as well as necrosis in the injection area. The preparation of a sustained release formulation based on lipid-liquid crystal that controls the release of NADC could be a potential solution to address the issue of inflammation and necrosis at the site of injection. To present a practical and validated app...
Source: AAPS PharmSciTech - November 9, 2023 Category: Drugs & Pharmacology Authors: Maryam Kouhjani Arezoo Saberi Farzin Hadizadeh Elham Khodaverdi Malihe Karimi Elaheh Gholizadeh Hossein Kamali Ali Nokhodchi Source Type: research

Nanohybrid Based on (Mn, Zn) Ferrite Nanoparticles Functionalized With Chitosan and Sodium Alginate for Loading of Curcumin Against Human Breast Cancer Cells
This study reports on the synthesis of Mn1 - xZnxFe2O4 (Mn, Zn ferrite) magnetic nanoparticles (MNPs) as drug delivery carriers for effective therapeutic outcomes. The MNPs were prepared using the coprecipitation method, and their magnetic properties were investigated based on their composition. Among the compositions tested, Mn0.8Zn0.2Fe2O4 MNPs exhibited superparamagnetic properties with a saturation magnetization moment of 34.6 emu/g at room temperature (25°C). To enhance the water solubility of curcumin (Cur), known for its hydrophobic nature, it was successfully loaded onto alginate (Alg)/chitosan (Chit)@Mn0.8Zn0.2Fe...
Source: AAPS PharmSciTech - November 7, 2023 Category: Drugs & Pharmacology Authors: Fatemeh Ahmadi Majid Saeedi Jafar Akbari Mohammad Seyedabadi Pedram Ebrahimnejad Katayoun Morteza-Semnani Shahram Ghasemi Monire Moalem-Banhangi Amirhossein Babaei Seyyed Mohammad Hassan Hashemi Kofi Asare-Addo Ali Nokhodchi Source Type: research

Nanohybrid Based on (Mn, Zn) Ferrite Nanoparticles Functionalized With Chitosan and Sodium Alginate for Loading of Curcumin Against Human Breast Cancer Cells
This study reports on the synthesis of Mn1 - xZnxFe2O4 (Mn, Zn ferrite) magnetic nanoparticles (MNPs) as drug delivery carriers for effective therapeutic outcomes. The MNPs were prepared using the coprecipitation method, and their magnetic properties were investigated based on their composition. Among the compositions tested, Mn0.8Zn0.2Fe2O4 MNPs exhibited superparamagnetic properties with a saturation magnetization moment of 34.6 emu/g at room temperature (25°C). To enhance the water solubility of curcumin (Cur), known for its hydrophobic nature, it was successfully loaded onto alginate (Alg)/chitosan (Chit)@Mn0.8Zn0.2Fe...
Source: AAPS PharmSciTech - November 7, 2023 Category: Drugs & Pharmacology Authors: Fatemeh Ahmadi Majid Saeedi Jafar Akbari Mohammad Seyedabadi Pedram Ebrahimnejad Katayoun Morteza-Semnani Shahram Ghasemi Monire Moalem-Banhangi Amirhossein Babaei Seyyed Mohammad Hassan Hashemi Kofi Asare-Addo Ali Nokhodchi Source Type: research

Effects of Sodium Salts of Fatty Acids and Their Derivatives on Skin Permeation of Cromolyn Sodium
AAPS PharmSciTech. 2023 Nov 2;24(8):221. doi: 10.1208/s12249-023-02676-8.ABSTRACTAtopic dermatitis is a chronic inflammatory disorder with rising prevalence. The safety concerns over usually used steroids are driving the need for developing an effective atopic dermatitis treatment. The use of therapeutic agents such as cromolyn sodium (CS) is suggested. However, due to its physicochemical properties, CS permeation across the skin is a challenge. The aim of this study was to investigate the effect of sodium salts of fatty acids or their derivatives with varied carbon chain lengths as potential enhancers on the skin permeati...
Source: AAPS PharmSciTech - November 3, 2023 Category: Drugs & Pharmacology Authors: Olasunkanmi Evelyn Akinbote Gabrielle Verana Amruta A Dandekar Akeemat O Tijani Dhruv Mishra Ashana Puri Steven Dinh Source Type: research