Potential Applications and Additive Manufacturing Technology-Based Considerations of Mesoporous Silica: A Review
AAPS PharmSciTech. 2023 Dec 21;25(1):6. doi: 10.1208/s12249-023-02720-7.ABSTRACTNanoporous materials are categorized as microporous (pore sizes 0.2-2 nm), mesoporous (pore sizes 2-50 nm), and macroporous (pore sizes 50-1000 nm). Mesoporous silica (MS) has gained a significant interest due to its notable characteristics, including organized pore networks, specific surface areas, and the ability to be integrated in a variety of morphologies. Recently, MS has been widely accepted by range of manufacturer and as drug carrier. Moreover, silica nanoparticles containing mesopores, also known as mesoporous silica nanoparticles (MS...
Source: AAPS PharmSciTech - December 22, 2023 Category: Drugs & Pharmacology Authors: Jigar Vyas Sudarshan Singh Isha Shah Bhupendra G Prajapati Source Type: research
Evaluation of Dose-Response Relationship of Permeation Enhancer Isopropyl Myristate Release on Drug Release: Release Enhancement Efficiency and Molecular Mechanism
The objective of this study is to investigate the dose-response relationship between various concentrations of permeation enhancers (PEs) and their ability to enhance drug release from a polymer matrix, utilizing an innovative parameter known as release enhancement efficiency (K). Additionally, the molecular mechanism underlying dynamic enhancement was also examined. Isopropyl myristate (IPM) was used as model enhancer and zolmitriptan (ZOL) was used as model drug to investigate dose-effect relationship in pressure sensitive adhesives (PSA). The release behavior of the PEs was determined by LC-MS/MS and verified by confoca...
Source: AAPS PharmSciTech - December 20, 2023 Category: Drugs & Pharmacology Authors: Jiuheng Ruan Sida Liao Jinye Tang Liang Fang Source Type: research
Preparation of Tetrandrine Nanocrystals by Microfluidic Method and Its In Vitro and In Vivo Evaluation
The objectives of this study were to prepare TET nanocrystals (TET-NC@GL) using a Y-microfluidic method with glycyrrhetinic acid (GL) as a stabilizer. The optimal preparation prescription was determined through a single-factor test and Box-Behnken response surface method. Additionally, the nanocrystals prepared with the commonly used stabilizer polyvinylpyrrolidone K30 (PVPK30), known as TET-NC@PVPK30, were characterized and evaluated for their toxicity to HepG2 cells. Hybridized nanocrystals (TET-HNC@GL and TET-HNC@PVPK30) were synthesized using a water-soluble aggregation-induced emission (AIE) fluorescent probe (TVP). Q...
Source: AAPS PharmSciTech - December 20, 2023 Category: Drugs & Pharmacology Authors: Jinping Huang Shuwen Huang Shengjun Liu Lizhen Feng Wenxiu Huang Yao Wang Dongyi Huang Tingting Huang Xingzhen Huang Source Type: research
Dissolution Profiles Comparison Using Conventional and Bias Corrected and Accelerated f2 Bootstrap Approaches with Different Software's: Impact of Variability, Sample Size and Number of Bootstraps
AAPS PharmSciTech. 2023 Dec 20;25(1):5. doi: 10.1208/s12249-023-02710-9.ABSTRACTDissolution profiles comparison is an important element in order to support biowaivers, scale-up and post approval changes and site transfers. Highly variable dissolution can possess significant challenges for comparison and f2 bootstrap approach can be utilized in such cases. However, availability of different types of f2 and confidence intervals (CI) methods indicates necessity to understand each type of calculation thoroughly. Among all approaches, bias corrected and accelerated (BCa) can be an attractive choice as it corrects the bias and s...
Source: AAPS PharmSciTech - December 20, 2023 Category: Drugs & Pharmacology Authors: Rajkumar Boddu Sivacharan Kollipara Adithya Karthik Bhattiprolu Karthik Parsa Sanketh Kumar Chakilam Krishna Reddy Daka Ashima Bhatia Tausif Ahmed Source Type: research
Evaluation of Dose-Response Relationship of Permeation Enhancer Isopropyl Myristate Release on Drug Release: Release Enhancement Efficiency and Molecular Mechanism
The objective of this study is to investigate the dose-response relationship between various concentrations of permeation enhancers (PEs) and their ability to enhance drug release from a polymer matrix, utilizing an innovative parameter known as release enhancement efficiency (K). Additionally, the molecular mechanism underlying dynamic enhancement was also examined. Isopropyl myristate (IPM) was used as model enhancer and zolmitriptan (ZOL) was used as model drug to investigate dose-effect relationship in pressure sensitive adhesives (PSA). The release behavior of the PEs was determined by LC-MS/MS and verified by confoca...
Source: AAPS PharmSciTech - December 20, 2023 Category: Drugs & Pharmacology Authors: Jiuheng Ruan Sida Liao Jinye Tang Liang Fang Source Type: research
Preparation of Tetrandrine Nanocrystals by Microfluidic Method and Its In Vitro and In Vivo Evaluation
The objectives of this study were to prepare TET nanocrystals (TET-NC@GL) using a Y-microfluidic method with glycyrrhetinic acid (GL) as a stabilizer. The optimal preparation prescription was determined through a single-factor test and Box-Behnken response surface method. Additionally, the nanocrystals prepared with the commonly used stabilizer polyvinylpyrrolidone K30 (PVPK30), known as TET-NC@PVPK30, were characterized and evaluated for their toxicity to HepG2 cells. Hybridized nanocrystals (TET-HNC@GL and TET-HNC@PVPK30) were synthesized using a water-soluble aggregation-induced emission (AIE) fluorescent probe (TVP). Q...
Source: AAPS PharmSciTech - December 20, 2023 Category: Drugs & Pharmacology Authors: Jinping Huang Shuwen Huang Shengjun Liu Lizhen Feng Wenxiu Huang Yao Wang Dongyi Huang Tingting Huang Xingzhen Huang Source Type: research
Dissolution Profiles Comparison Using Conventional and Bias Corrected and Accelerated f2 Bootstrap Approaches with Different Software's: Impact of Variability, Sample Size and Number of Bootstraps
AAPS PharmSciTech. 2023 Dec 20;25(1):5. doi: 10.1208/s12249-023-02710-9.ABSTRACTDissolution profiles comparison is an important element in order to support biowaivers, scale-up and post approval changes and site transfers. Highly variable dissolution can possess significant challenges for comparison and f2 bootstrap approach can be utilized in such cases. However, availability of different types of f2 and confidence intervals (CI) methods indicates necessity to understand each type of calculation thoroughly. Among all approaches, bias corrected and accelerated (BCa) can be an attractive choice as it corrects the bias and s...
Source: AAPS PharmSciTech - December 20, 2023 Category: Drugs & Pharmacology Authors: Rajkumar Boddu Sivacharan Kollipara Adithya Karthik Bhattiprolu Karthik Parsa Sanketh Kumar Chakilam Krishna Reddy Daka Ashima Bhatia Tausif Ahmed Source Type: research
Evaluation of Dose-Response Relationship of Permeation Enhancer Isopropyl Myristate Release on Drug Release: Release Enhancement Efficiency and Molecular Mechanism
The objective of this study is to investigate the dose-response relationship between various concentrations of permeation enhancers (PEs) and their ability to enhance drug release from a polymer matrix, utilizing an innovative parameter known as release enhancement efficiency (K). Additionally, the molecular mechanism underlying dynamic enhancement was also examined. Isopropyl myristate (IPM) was used as model enhancer and zolmitriptan (ZOL) was used as model drug to investigate dose-effect relationship in pressure sensitive adhesives (PSA). The release behavior of the PEs was determined by LC-MS/MS and verified by confoca...
Source: AAPS PharmSciTech - December 20, 2023 Category: Drugs & Pharmacology Authors: Jiuheng Ruan Sida Liao Jinye Tang Liang Fang Source Type: research
Preparation of Tetrandrine Nanocrystals by Microfluidic Method and Its In Vitro and In Vivo Evaluation
The objectives of this study were to prepare TET nanocrystals (TET-NC@GL) using a Y-microfluidic method with glycyrrhetinic acid (GL) as a stabilizer. The optimal preparation prescription was determined through a single-factor test and Box-Behnken response surface method. Additionally, the nanocrystals prepared with the commonly used stabilizer polyvinylpyrrolidone K30 (PVPK30), known as TET-NC@PVPK30, were characterized and evaluated for their toxicity to HepG2 cells. Hybridized nanocrystals (TET-HNC@GL and TET-HNC@PVPK30) were synthesized using a water-soluble aggregation-induced emission (AIE) fluorescent probe (TVP). Q...
Source: AAPS PharmSciTech - December 20, 2023 Category: Drugs & Pharmacology Authors: Jinping Huang Shuwen Huang Shengjun Liu Lizhen Feng Wenxiu Huang Yao Wang Dongyi Huang Tingting Huang Xingzhen Huang Source Type: research
Separable and Inseparable Silk Fibroin Microneedles for the Transdermal Delivery of Colchicine: Development, Characterization, and Comparisons
In conclusion, the separable silk fibroin-based microneedles provide a promising route for colchicine delivery.PMID:38114734 | DOI:10.1208/s12249-023-02716-3 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - December 19, 2023 Category: Drugs & Pharmacology Authors: Shiji Liao Guirong Qiu Yanping Hu Bohong Guo Yuqin Qiu Source Type: research
In Vivo Cancer Microenvironment Responsive Glycan Receptor-Targeted Nanoparticles for Gemcitabine Delivery to Benzo[a]pyrene-Induced Lung Cancer Model
AAPS PharmSciTech. 2023 Dec 19;25(1):2. doi: 10.1208/s12249-023-02714-5.ABSTRACTTargeted gemcitabine (GEB) loaded 5-N-acetyl-neuraminic acid (Neu5Ac) assembled chitosan nanoparticles (CA-NPs) were formulated by ionotropic gelation process and evaluated for physicochemical and morphological characterization, in vitro and in vivo studies in A-549 cells and lung cancer mice model, respectively. The mean diameter of GEB-CA-Neu5Ac-NPs determined by dynamic light scattering was 161.16 ± 7.70 nm with a polydispersity index (PDI) value of 0.303 ± 0.011 and its zeta potential and entrapment efficiency (%EE) were 40.3 ± 3.45 mv a...
Source: AAPS PharmSciTech - December 19, 2023 Category: Drugs & Pharmacology Authors: Krishan Kumar Rinki Verma None Manjit None Priya Mohini Mishra Varsha Rani Ruchi Chawla Source Type: research
Recent Advances of Multifunctional PLGA Nanocarriers in the Management of Triple-Negative Breast Cancer
AAPS PharmSciTech. 2023 Dec 14;24(8):258. doi: 10.1208/s12249-023-02712-7.ABSTRACTEven though chemotherapy stands as a standard option in the therapy of TNBC, problems associated with it such as anemia, bone marrow suppression, immune suppression, toxic effects on healthy cells, and multi-drug resistance (MDR) can compromise their effects. Nanoparticles gained paramount importance in overcoming the limitations of conventional chemotherapy. Among the various options, nanotechnology has appeared as a promising path in preclinical and clinical studies for early diagnosis of primary tumors and metastases and destroying tumor c...
Source: AAPS PharmSciTech - December 14, 2023 Category: Drugs & Pharmacology Authors: Yirivinti Hayagreeva Dinakar Naveen Rajana Nalla Usha Kumari Vikas Jain Neelesh Kumar Mehra Source Type: research
Recent Advances of Multifunctional PLGA Nanocarriers in the Management of Triple-Negative Breast Cancer
AAPS PharmSciTech. 2023 Dec 14;24(8):258. doi: 10.1208/s12249-023-02712-7.ABSTRACTEven though chemotherapy stands as a standard option in the therapy of TNBC, problems associated with it such as anemia, bone marrow suppression, immune suppression, toxic effects on healthy cells, and multi-drug resistance (MDR) can compromise their effects. Nanoparticles gained paramount importance in overcoming the limitations of conventional chemotherapy. Among the various options, nanotechnology has appeared as a promising path in preclinical and clinical studies for early diagnosis of primary tumors and metastases and destroying tumor c...
Source: AAPS PharmSciTech - December 14, 2023 Category: Drugs & Pharmacology Authors: Yirivinti Hayagreeva Dinakar Naveen Rajana Nalla Usha Kumari Vikas Jain Neelesh Kumar Mehra Source Type: research
Recent Advances of Multifunctional PLGA Nanocarriers in the Management of Triple-Negative Breast Cancer
AAPS PharmSciTech. 2023 Dec 14;24(8):258. doi: 10.1208/s12249-023-02712-7.ABSTRACTEven though chemotherapy stands as a standard option in the therapy of TNBC, problems associated with it such as anemia, bone marrow suppression, immune suppression, toxic effects on healthy cells, and multi-drug resistance (MDR) can compromise their effects. Nanoparticles gained paramount importance in overcoming the limitations of conventional chemotherapy. Among the various options, nanotechnology has appeared as a promising path in preclinical and clinical studies for early diagnosis of primary tumors and metastases and destroying tumor c...
Source: AAPS PharmSciTech - December 14, 2023 Category: Drugs & Pharmacology Authors: Yirivinti Hayagreeva Dinakar Naveen Rajana Nalla Usha Kumari Vikas Jain Neelesh Kumar Mehra Source Type: research
Recent Advances of Multifunctional PLGA Nanocarriers in the Management of Triple-Negative Breast Cancer
AAPS PharmSciTech. 2023 Dec 14;24(8):258. doi: 10.1208/s12249-023-02712-7.ABSTRACTEven though chemotherapy stands as a standard option in the therapy of TNBC, problems associated with it such as anemia, bone marrow suppression, immune suppression, toxic effects on healthy cells, and multi-drug resistance (MDR) can compromise their effects. Nanoparticles gained paramount importance in overcoming the limitations of conventional chemotherapy. Among the various options, nanotechnology has appeared as a promising path in preclinical and clinical studies for early diagnosis of primary tumors and metastases and destroying tumor c...
Source: AAPS PharmSciTech - December 14, 2023 Category: Drugs & Pharmacology Authors: Yirivinti Hayagreeva Dinakar Naveen Rajana Nalla Usha Kumari Vikas Jain Neelesh Kumar Mehra Source Type: research
