Development of Epigallocatechin 3-gallate-Loaded Hydrogel Nanocomposites for Oral Submucous Fibrosis
This study aimed to evaluate epigallocatechin 3-gallate (EGCG) encapsulated nanoparticles loaded mucoadhesive hydrogel nanocomposite (HNC) for OSF. Developed HNC formulations were evaluated for their permeation behaviour using in vitro as well as ex vivo studies, followed by evaluation of efficacy and safety by in vivo studies using areca nut extract-induced OSF in rats. The disease condition in OSF-induced rats was assessed by mouth-opening and biochemical markers. The optimized polymeric nanoparticles exhibited the required particle size (162.93 ± 13.81 nm), positive zeta potential (22.50 ± 2.94 mV) with better mucoadh...
Source: AAPS PharmSciTech - March 23, 2024 Category: Drugs & Pharmacology Authors: Chetan Hasmukh Mehta Varalakshmi Velagacherla Suman Manandhar Yogendra Nayak Sreedhara Ranganath K Pai Shruthi Acharya Usha Yogendra Nayak Source Type: research
A Comprehensive Review of Hydrogel-Based Drug Delivery Systems: Classification, Properties, Recent Trends, and Applications
AAPS PharmSciTech. 2024 Mar 21;25(4):64. doi: 10.1208/s12249-024-02786-x.ABSTRACTAs adaptable biomaterials, hydrogels have shown great promise in several industries, which include the delivery of drugs, engineering of tissues, biosensing, and regenerative medicine. These hydrophilic polymer three-dimensional networks have special qualities like increased content of water, soft, flexible nature, as well as biocompatibility, which makes it excellent candidates for simulating the extracellular matrix and promoting cell development and tissue regeneration. With an emphasis on their design concepts, synthesis processes, and cha...
Source: AAPS PharmSciTech - March 22, 2024 Category: Drugs & Pharmacology Authors: Huma Hameed Saleha Faheem Ana Cl áudia Paiva-Santos Hafiz Shoaib Sarwar Muhammad Jamshaid Source Type: research
A Comprehensive Review of Hydrogel-Based Drug Delivery Systems: Classification, Properties, Recent Trends, and Applications
AAPS PharmSciTech. 2024 Mar 21;25(4):64. doi: 10.1208/s12249-024-02786-x.ABSTRACTAs adaptable biomaterials, hydrogels have shown great promise in several industries, which include the delivery of drugs, engineering of tissues, biosensing, and regenerative medicine. These hydrophilic polymer three-dimensional networks have special qualities like increased content of water, soft, flexible nature, as well as biocompatibility, which makes it excellent candidates for simulating the extracellular matrix and promoting cell development and tissue regeneration. With an emphasis on their design concepts, synthesis processes, and cha...
Source: AAPS PharmSciTech - March 22, 2024 Category: Drugs & Pharmacology Authors: Huma Hameed Saleha Faheem Ana Cl áudia Paiva-Santos Hafiz Shoaib Sarwar Muhammad Jamshaid Source Type: research
Retraction Note: Natural Polymer-Based Graphene Oxide Bio-nanocomposite Hydrogel Beads: Superstructures with Advanced Potentials for Drug Delivery
AAPS PharmSciTech. 2024 Mar 19;25(4):63. doi: 10.1208/s12249-024-02788-9.NO ABSTRACTPMID:38502375 | DOI:10.1208/s12249-024-02788-9 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - March 19, 2024 Category: Drugs & Pharmacology Authors: Sadia Rehman Asadullah Madni Qazi Adnan Jameel Faisal Usman M Rafi Raza Faiz Ahmad Hina Shoukat Hamdan Aali Afifa Shafiq Source Type: research
Retraction Note: Natural Polymer-Based Graphene Oxide Bio-nanocomposite Hydrogel Beads: Superstructures with Advanced Potentials for Drug Delivery
AAPS PharmSciTech. 2024 Mar 19;25(4):63. doi: 10.1208/s12249-024-02788-9.NO ABSTRACTPMID:38502375 | DOI:10.1208/s12249-024-02788-9 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - March 19, 2024 Category: Drugs & Pharmacology Authors: Sadia Rehman Asadullah Madni Qazi Adnan Jameel Faisal Usman M Rafi Raza Faiz Ahmad Hina Shoukat Hamdan Aali Afifa Shafiq Source Type: research
Retraction Note: Natural Polymer-Based Graphene Oxide Bio-nanocomposite Hydrogel Beads: Superstructures with Advanced Potentials for Drug Delivery
AAPS PharmSciTech. 2024 Mar 19;25(4):63. doi: 10.1208/s12249-024-02788-9.NO ABSTRACTPMID:38502375 | DOI:10.1208/s12249-024-02788-9 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - March 19, 2024 Category: Drugs & Pharmacology Authors: Sadia Rehman Asadullah Madni Qazi Adnan Jameel Faisal Usman M Rafi Raza Faiz Ahmad Hina Shoukat Hamdan Aali Afifa Shafiq Source Type: research
Correction to: An in vitro Assessment of Thermo-Reversible Gel Formulation Containing Sunitinib Nanoparticles for Neovascular Age-Related Macular Degeneration
AAPS PharmSciTech. 2024 Mar 14;25(3):62. doi: 10.1208/s12249-024-02782-1.NO ABSTRACTPMID:38485865 | DOI:10.1208/s12249-024-02782-1 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - March 15, 2024 Category: Drugs & Pharmacology Authors: Priyanka Bhatt Priya Narvekar Rohan Lalani Mahavir Bhupal Chougule Yashwant Pathak Vijaykumar Sutariya Source Type: research
Formulation, Characterization and In Vitro Evaluation of Mesalamine and Bifidobacterium bifidum Loaded Hydrogel Beads in Capsule System for Colon Targeted Delivery
AAPS PharmSciTech. 2024 Mar 14;25(3):61. doi: 10.1208/s12249-024-02764-3.ABSTRACTMesalamine is a first-line drug for the treatment of inflammatory bowel diseases. However, its premature release associated with marketed formulations leads to adverse effects like gastric trouble, vomiting, and diarrhoea. To minimize these side effects, colon-targeted drug delivery is essential. Besides conventional pharmacotherapy, bifidogenic probiotics with anti-inflammatory activity has been reported to elicit a significant impact on the remission of ulcerative colitis. Bifidogenic probiotics being acid-labile necessitate developing a gas...
Source: AAPS PharmSciTech - March 15, 2024 Category: Drugs & Pharmacology Authors: Jagtar Singh Mohit Sharma Harmeet Singh Pinky Arora Puneet Utreja Shubham Kumar Source Type: research
Correction to: An in vitro Assessment of Thermo-Reversible Gel Formulation Containing Sunitinib Nanoparticles for Neovascular Age-Related Macular Degeneration
AAPS PharmSciTech. 2024 Mar 14;25(3):62. doi: 10.1208/s12249-024-02782-1.NO ABSTRACTPMID:38485865 | DOI:10.1208/s12249-024-02782-1 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - March 15, 2024 Category: Drugs & Pharmacology Authors: Priyanka Bhatt Priya Narvekar Rohan Lalani Mahavir Bhupal Chougule Yashwant Pathak Vijaykumar Sutariya Source Type: research
Formulation, Characterization and In Vitro Evaluation of Mesalamine and Bifidobacterium bifidum Loaded Hydrogel Beads in Capsule System for Colon Targeted Delivery
AAPS PharmSciTech. 2024 Mar 14;25(3):61. doi: 10.1208/s12249-024-02764-3.ABSTRACTMesalamine is a first-line drug for the treatment of inflammatory bowel diseases. However, its premature release associated with marketed formulations leads to adverse effects like gastric trouble, vomiting, and diarrhoea. To minimize these side effects, colon-targeted drug delivery is essential. Besides conventional pharmacotherapy, bifidogenic probiotics with anti-inflammatory activity has been reported to elicit a significant impact on the remission of ulcerative colitis. Bifidogenic probiotics being acid-labile necessitate developing a gas...
Source: AAPS PharmSciTech - March 15, 2024 Category: Drugs & Pharmacology Authors: Jagtar Singh Mohit Sharma Harmeet Singh Pinky Arora Puneet Utreja Shubham Kumar Source Type: research
Correction to: An in vitro Assessment of Thermo-Reversible Gel Formulation Containing Sunitinib Nanoparticles for Neovascular Age-Related Macular Degeneration
AAPS PharmSciTech. 2024 Mar 14;25(3):62. doi: 10.1208/s12249-024-02782-1.NO ABSTRACTPMID:38485865 | DOI:10.1208/s12249-024-02782-1 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - March 15, 2024 Category: Drugs & Pharmacology Authors: Priyanka Bhatt Priya Narvekar Rohan Lalani Mahavir Bhupal Chougule Yashwant Pathak Vijaykumar Sutariya Source Type: research
Formulation, Characterization and In Vitro Evaluation of Mesalamine and Bifidobacterium bifidum Loaded Hydrogel Beads in Capsule System for Colon Targeted Delivery
AAPS PharmSciTech. 2024 Mar 14;25(3):61. doi: 10.1208/s12249-024-02764-3.ABSTRACTMesalamine is a first-line drug for the treatment of inflammatory bowel diseases. However, its premature release associated with marketed formulations leads to adverse effects like gastric trouble, vomiting, and diarrhoea. To minimize these side effects, colon-targeted drug delivery is essential. Besides conventional pharmacotherapy, bifidogenic probiotics with anti-inflammatory activity has been reported to elicit a significant impact on the remission of ulcerative colitis. Bifidogenic probiotics being acid-labile necessitate developing a gas...
Source: AAPS PharmSciTech - March 15, 2024 Category: Drugs & Pharmacology Authors: Jagtar Singh Mohit Sharma Harmeet Singh Pinky Arora Puneet Utreja Shubham Kumar Source Type: research
Correction to: An in vitro Assessment of Thermo-Reversible Gel Formulation Containing Sunitinib Nanoparticles for Neovascular Age-Related Macular Degeneration
AAPS PharmSciTech. 2024 Mar 14;25(3):62. doi: 10.1208/s12249-024-02782-1.NO ABSTRACTPMID:38485865 | DOI:10.1208/s12249-024-02782-1 (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - March 15, 2024 Category: Drugs & Pharmacology Authors: Priyanka Bhatt Priya Narvekar Rohan Lalani Mahavir Bhupal Chougule Yashwant Pathak Vijaykumar Sutariya Source Type: research
Formulation, Characterization and In Vitro Evaluation of Mesalamine and Bifidobacterium bifidum Loaded Hydrogel Beads in Capsule System for Colon Targeted Delivery
AAPS PharmSciTech. 2024 Mar 14;25(3):61. doi: 10.1208/s12249-024-02764-3.ABSTRACTMesalamine is a first-line drug for the treatment of inflammatory bowel diseases. However, its premature release associated with marketed formulations leads to adverse effects like gastric trouble, vomiting, and diarrhoea. To minimize these side effects, colon-targeted drug delivery is essential. Besides conventional pharmacotherapy, bifidogenic probiotics with anti-inflammatory activity has been reported to elicit a significant impact on the remission of ulcerative colitis. Bifidogenic probiotics being acid-labile necessitate developing a gas...
Source: AAPS PharmSciTech - March 15, 2024 Category: Drugs & Pharmacology Authors: Jagtar Singh Mohit Sharma Harmeet Singh Pinky Arora Puneet Utreja Shubham Kumar Source Type: research
Preclinical Development of a Novel Epitope-based DNA Vaccine Candidate against SARS-CoV-2 and Evaluation of Immunogenicity in BALB/c Mice
This study demonstrated that the DNA vaccine construct encoding highly conserved immunogenic B and T cell epitopes was capable of eliciting potent humoral and cellular immune responses in mice.PMID:38472523 | DOI:10.1208/s12249-024-02778-x (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - March 13, 2024 Category: Drugs & Pharmacology Authors: Kanwal Khalid Hui Xuan Lim Ayaz Anwar Soon Hao Tan Jung Shan Hwang Seng-Kai Ong Chit Laa Poh Source Type: research
