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The improving Medication Adherence in Adolescents and young adults following Liver Transplantation (iMALT) multisite trial: Design and trial implementation considerations
DISCUSSION: Improving Medication Adherence in adolescent Liver Transplant includes several innovative design elements. The use of a validated, objective adherence index to survey a large cohort of transplant recipients allows the teams to avoid bias inherent in both convenience sampling and referral-based recruitment and enroll only patients whose computed index indicates substantially increased risk of rejection. The remote intervention paradigm helps to engage patients who are by definition hard to engage. The use of an objective, masked medical (rather than behavioral) outcome measure reduces the likelihood of biases re...
Source: Clinical Trials - June 3, 2023 Category: Research Authors: Eyal Shemesh Sarah Duncan-Park George Mazariegos Rachel Annunziato Ravinder Anand Miguel Reyes-Mugica Jeff Mitchell Benjamin L Shneider for iMALT Source Type: research

Revolutionize your research with the NIH Comparative Genomics Resource (CGR)
Unlock the full potential of eukaryotic research organisms and their genomic data with the National Institutes of Health (NIH) Comparative Genomics Resource (CGR). CGR facilitates reliable comparative genomics analyses through community collaboration as well as an NCBI toolkit of interconnected, interoperable data and tools.    Comparative genomics is a field of study that uses the … Continue reading Revolutionize your research with the NIH Comparative Genomics Resource (CGR) →
Source: NCBI Insights - June 1, 2023 Category: Databases & Libraries Authors: NCBI Staff Tags: What's New Basic Local Alignment Search Tool (BLAST) ClusteredNR Comparative Genome Viewer (CGV) Comparative Genomics Resource (CGR) Datasets Eukaryotic genome annotation GenBank Genome Data Viewer (GDV) Multiple Sequence Alignment Viewe Source Type: news

2023 Masters in Hospital Medicine
SHM’s outgoing president Rachel Thompson, MD, MPH, SFHM, kicked off SHM Converge 2023 in Austin, Texas in March by honoring the newest members to become Masters in Hospital Medicine. “They join 39 other Masters in Hospital Medicine,” Dr. Thompson said. “For a total of 43 from a universe of tens of thousands worldwide.” Pictured above, left to right SHM CEO, Dr. Eric Howell with the new MHM members Danielle B. Scheurer, MD, MSCR, MHM, Daniel Payson Hunt, MD, MHM, Margaret C. Fang, MD, MPH, MHM, Alpesh N. Amin, MD, MBA, MACP, MHM, and Dr. Thompson. Dr. Amin Alpesh N. Amin, MD, MBA, MACP, MHM, was elected to the p...
Source: The Hospitalist - June 1, 2023 Category: Hospital Management Authors: Ronda Whitaker Tags: Awards Career Source Type: research

Editor's Spotlight/Take 5: Fewer Than One in 20 Current Academic Orthopaedic Surgeons Have Obtained National Institutes of Health Funding
Clin Orthop Relat Res. 2023 Jun 1. doi: 10.1097/CORR.0000000000002724. Online ahead of print.NO ABSTRACTPMID:37262089 | DOI:10.1097/CORR.0000000000002724
Source: Clinical Orthopaedics and Related Research - June 1, 2023 Category: Orthopaedics Authors: Seth S Leopold Source Type: research

Psychedelics: Threshold of a Therapeutic Revolution
Neuropharmacology. 2023 May 27:109610. doi: 10.1016/j.neuropharm.2023.109610. Online ahead of print.ABSTRACTThis Special Issue of Neuropharmacology on psychedelics provides a timely and comprehensive update on progress following the previous Neuropharmacology Special Issue "Psychedelics: New Doors, Altered Perceptions". Remarkable advances have been made in basic and clinical research on psychedelics in the five years since 2018. It is partly based on the seminar series focused on psilocybin organized by the National Institutes of Health (NIH), USA from April to June 2021, the "NIH Psilocybin Research Speaker Series". Part...
Source: Neuropharmacology - May 29, 2023 Category: Drugs & Pharmacology Authors: D J Heal S L Smith S J Belouin J E Henningfield Source Type: research

Longitudinal transitions in e-cigarette and cigarette use among US adults: prospective cohort study
We examined behavioral transitions (initiation, relapse, progression, and cessation) in ENDS and cigarette use across waves. Weighted generalized estimating equation models adjusted for sociodemographic variables.FINDINGS: Of never ENDS users at baseline, an estimated 1.7% reported initiating ENDS use by follow-up. Of former ENDS users, an estimated 12.1% relapsed into ENDS use. Of periodic ENDS users at baseline, 13% progressed to established ENDS use. Of baseline current ENDS users, 46.3% discontinued ENDS use. The corresponding transitions for cigarette smoking were 1.6% (initiation), 4.8% (relapse), 21.1% (progression)...
Source: Cancer Control - May 25, 2023 Category: Cancer & Oncology Authors: Mohammad Ebrahimi Kalan Noel T Brewer Source Type: research

Is low-risk status a surrogate outcome in pulmonary arterial hypertension? An analysis of three randomised trials
Lancet Respir Med. 2023 May 22:S2213-2600(23)00155-8. doi: 10.1016/S2213-2600(23)00155-8. Online ahead of print.ABSTRACTBACKGROUND: Targeting short-term improvements in multicomponent risk scores for mortality in patients with pulmonary arterial hypertension (PAH) could result in improved long-term outcomes. We aimed to determine whether PAH risk scores were adequate surrogates for clinical worsening or mortality outcomes in PAH randomised clinical trials (RCTs).METHODS: We performed an individual participant data meta-analysis of RCTs selected from PAH trials provided by the US Food and Drug Administration (FDA). We calcu...
Source: Respiratory Care - May 25, 2023 Category: Respiratory Medicine Authors: Bryan S Blette Jude Moutchia Nadine Al-Naamani Corey E Ventetuolo Chao Cheng Dina Appleby Ryan J Urbanowicz Jason Fritz Jeremy A Mazurek Fan Li Steven M Kawut Michael O Harhay Source Type: research

Biden Picks Cancer Surgeon Monica Bertagnolli to Head NIH Biden Picks Cancer Surgeon Monica Bertagnolli to Head NIH
The Biden administration said it intends to nominate cancer surgeon Dr Monica Bertagnolli to lead the National Institutes of Health following a 16-month search for a permanent successor to the agency ' s long-serving director.Reuters Health Information
Source: Medscape Hematology-Oncology Headlines - May 16, 2023 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Scientists use AI to identify likely drug targets in search for Alzheimer ' s cure
Scientists use AI to identify likely drug targets in search for Alzheimer's cure A team led by a University of Arizona College of Medicine – Tucson scientist harnesses artificial intelligence to trace the path from a healthy brain cell to one afflicted by Alzheimer ' s disease. Anna C. Christensen Today College of Medicine – TucsonRui-Chang_khp-web.jpg Rui Chang, an associate professor of neurology, is leading a team at the College of Medicine – Tucson that uses artificial intelligence to trace the molecular path of the development of Alzheimer's disease.HealthCollege of Medicine - TucsonDeterminationE...
Source: The University of Arizona: Health - May 15, 2023 Category: Universities & Medical Training Authors: mittank Source Type: research