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Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era
World J Gastroenterol. 2023 Sep 7;29(33):4942-4961. doi: 10.3748/wjg.v29.i33.4942.ABSTRACTHepatitis due to hepatitis B virus (HBV) reactivation can be serious and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving chemotherapy, especially rituximab-containing therapy for hematological malignancies and those receiving stem cell transplantation. Patients with inactive and even resolved HBV infection still have persistence of HBV genomes in the liver. The expression of these silent genomes is controlled by the immune system. Suppression or ablation of immune cells, most imp...
Source: World Journal of Gastroenterology : WJG - September 21, 2023 Category: Gastroenterology Authors: Joyce Wing Yan Mak Alvin Wing Hin Law Kimmy Wan Tung Law Rita Ho Carmen Ka Man Cheung Man Fai Law Source Type: research

Diagnosis and treatment of adult patients with PTLD at different sites after liver transplantation: A three-case report and literature review
Transpl Immunol. 2023 Jun 29:101881. doi: 10.1016/j.trim.2023.101881. Online ahead of print.ABSTRACTPost-transplant lymphoproliferative disease (PTLD) is a rare complication accompanying organ transplantation. Herein, we presented 3 cases of PTLD with different primary sites. All three patients presented with symptoms in the corresponding organs or sites and the latter two patients started with atypical symptoms of infections. The first two patients who developed the disease about a year after liver transplantation both had EBV infections. All three patients received immunosuppressant reduction and antiviral therapy. In ca...
Source: Transplant Immunology - July 1, 2023 Category: Transplant Surgery Authors: Yanchao Zhang Yi Lv Bo Wang Chang Liu Rongqian Wu Xiaogang Zhang Yu Li Min Tian Source Type: research

Prediction model of hepatitis B virus-related hepatocellular carcinoma in patients receiving antiviral therapy
J Formos Med Assoc. 2023 Jun 15:S0929-6646(23)00198-5. doi: 10.1016/j.jfma.2023.05.029. Online ahead of print.ABSTRACTChronic hepatitis B virus (HBV) infection, which ultimately leads to liver cirrhosis, hepatic decompensation, and hepatocellular carcinoma (HCC), remains a significant disease burden worldwide. Despite the use of antiviral therapy (AVT) using oral nucleos(t)ide analogs (NUCs) with high genetic barriers, the risk of HCC development cannot be completely eliminated. Therefore, bi-annual surveillance of HCC using abdominal ultrasonography with or without tumor markers is recommended for at-risk populations. For...
Source: J Formos Med Assoc - June 17, 2023 Category: General Medicine Authors: Beom Kyung Kim Sang Hoon Ahn Source Type: research

Impact of Direct-Acting Antiviral Therapy on Liver Fibrosis Regression among People with Chronic HCV Infection: Results from a Real-Life Cohort in Patients Who Achieved Sustained Virological Response
Conclusions: Treatment with DAAs achieved high rates of LFR and a decrease in mean FibroScan® values in all subgroups.PMID:37109770 | PMC:PMC10141631 | DOI:10.3390/medicina59040814
Source: Medicina (Kaunas) - April 28, 2023 Category: Universities & Medical Training Authors: Alejandro Garc ía-Ros Senador Mor án Virginia N úñez Gonzalo Garc ía-Ros Guadalupe Ruiz Jos é García-Solano Source Type: research

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