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Procedure: Anesthesia
Therapy: Stem Cell Therapy
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Total 139 results found since Jan 2013.
Human umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice
CONCLUSIONS: Our study highlights the beneficial effects of hUC-MSC treatment on PND and provides a justification to consider the potential use of hUC-MSCs in the perioperative period.PMID:37735415 | DOI:10.1186/s13287-023-03499-x
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Penghui Wei Min Jia Xiangyi Kong Wenyuan Lyu Hao Feng Xinyi Sun Jianjun Li Jian-Jun Yang Source Type: research
Fetal Muse-based therapy prevents lethal radio-induced gastrointestinal syndrome by intestinal regeneration
CONCLUSION: Our findings indicate that a single injection of a small quantity of WJ-Muse may be a new and easy therapeutic strategy for treating lethal GIS.PMID:37568164 | DOI:10.1186/s13287-023-03425-1
Source: Cell Research - August 11, 2023 Category: Cytology Authors: Honorine Dushime St éphanie G Moreno Christine Linard Annie Adrait Yohann Cout é Juliette Peltzer S ébastien Messiaen Claire Torres Lydia Bensemmane Daniel Lewandowski Paul-Henri Romeo Vanessa Petit Nathalie Gault Source Type: research
Effects of nebulized adipose-derived mesenchymal stem cells on acute lung injury following smoke inhalation in sheep
CONCLUSION: Nebulized ASCs moderately improved pulmonary function and delayed the onset of ARDS.PMID:37494838 | DOI:10.1016/j.intimp.2023.110638
Source: International Immunopharmacology - July 26, 2023 Category: Allergy & Immunology Authors: Yosuke Niimi Tuvshintugs Baljinnyam Satoshi Fukuda Clark R Andersen John R Salsbury Jong O Lee Donald S Prough Perenlei Enkhbaatar Source Type: research
Exosomes derived from mesenchymal stem cells rescue cartilage injury in osteoarthritis through Ferroptosis by GOT1/CCR2 expression
This study aims to evaluate the potential pro-inflammatory effects and molecular mechanism of Mesenchymal stem cells-derived exosomes (MSC-Exos) in Osteoarthritis. Bilateral ovariectomy was carried out to induce osteoporosis under anesthesia for the mice. MC3T3-E1 cells were induced for 14 days.HE staining, Safranin O staining and Biomechanical parameter analysis were used in this experiment. MSC-Exos improved osteoarthritis in a mouse model by reducing inflammation levels, preventing ferroptosis, and inducing expression of GOT1/CCR2 to regulate ferroptosis. MSC-Exos also promoted cell growth and osteogenic differentiation...
Source: International Immunopharmacology - July 7, 2023 Category: Allergy & Immunology Authors: Song Peng Chang Sun Chengteng Lai Lei Zhang Source Type: research
Comprehensive analysis of local anesthetics affecting adipose stem cells, in vitro
CONCLUSION: Depending on our in vitro data, lidocaine, mepivacaine and ropivacaine could be applied at concentrations of 1 - 10 mM without affecting ASC survival. Contrariwise, bupivacaine at concentrations >100 µM should be administered with great caution. However, the differentiation of ASCs and the ASC's secretome might already be decreased by each local anesthetic at 1 mM.PMID:36988627 | DOI:10.1097/PRS.0000000000010460
Source: Hand Surgery - March 29, 2023 Category: Surgery Authors: Vincent G J Guillaume Ella F Lippold Justus P Beier Tim Ruhl Source Type: research
Maternal sevoflurane exposure affects neural stem cell differentiation in offspring rats through NRF2 signaling
Neurotoxicology. 2022 Dec;93:348-354. doi: 10.1016/j.neuro.2022.10.014. Epub 2022 Oct 27.ABSTRACTStudies have shown that sevoflurane, a halogenated inhalational anesthetic, interferes with neurogenesis in the developing rodent brain. However, the mechanisms by which sevoflurane affects neural stem cells (NSCs) differentiation require further elucidation. Pregnant rats (gestational day 14) were anesthetized with 3.5% sevoflurane for 2 h, with or without ML385 pretreatment. ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor. NRF2 expression and the downstream Sonic Hedgehog (SHH)/glioma-associat...
Source: Neurotoxicology - November 21, 2022 Category: Neurology Authors: Yinong Zhang Shihui Kuai Yi Zhang Hang Xue Ziyi Wu Ping Zhao Source Type: research
Sevoflurane Does Not Promote the Colony-Forming Ability of Human Mesenchymal Glioblastoma Stem Cells In Vitro
Conclusions: Sevoflurane at clinically used concentrations does not promote the colony-forming ability of human mesenchymal glioblastoma stem cells in vitro. It is very important for neurosurgeons and anesthesiologists to know that sevoflurane, a volatile anesthetic used in surgical anesthesia, would not exacerbate the disease course of GSCs.PMID:36363571 | DOI:10.3390/medicina58111614
Source: Medicina (Kaunas) - November 11, 2022 Category: Universities & Medical Training Authors: Tomohiro Shoji Mikio Hayashi Chisato Sumi Munenori Kusunoki Takeo Uba Yoshiyuki Matsuo Kiichi Hirota Source Type: research
