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Total 197 results found since Jan 2013.
Case Report: Case Series of Kocuria palustris Bacteremia among Immunocompromised Patients
We present three cases of bacteremia in immunocompromised patients admitted to our hospital; one patient was receiving chemotherapy for gall bladder carcinoma, the second was on maintenance hemodialysis for chronic kidney disease, and the third was receiving chemotherapy for acute myeloid leukemia. All three patients presented with a fever in the setting of neutropenia during the course of treatment with chemotherapy (in Cases 1 and 3) or hemodialysis (in Case 2). The blood culture samples of all the patients had pure isolates of Kocuria species K. palustris, which was identified by matrix assisted laser desorption ionisat...
Source: The American Journal of Tropical Medicine and Hygiene - September 18, 2023 Category: Tropical Medicine Authors: Gerlin Varghese Ashima Jamwal Deepika Sarawat Chinmoy Sahu Sangram Singh Patel Nidhi Tejan Source Type: research
Surgical management of peritoneal metastasis: Opportunities for pharmaceutical research
This study, to our knowledge, is the first to illustrate the implications of drug properties in the CRS + IPC efficacy against PM. While drugs are now an integral part of PM patient management, there is limited pharmaceutical research in this treatment setting (e.g., effects of hyperthermia or pressure on drug transport or release from delivery systems, pharmacokinetics, pharmacodynamics). Hence, CRS + IPC of PM represents an area where additional pharmaceutical research can assist further development and optimization.PMID:37574051 | DOI:10.1016/j.jconrel.2023.08.017
Source: Cancer Control - August 13, 2023 Category: Cancer & Oncology Authors: Michael G Wientjes Ze Lu Carlos H F Chan Kiran Turaga Jessie L S Au Source Type: research
Electrolytes Play a Role in Detecting Cisplatin-Induced Kidney Complications and May Even Prevent Them-Retrospective Analysis
Conclusions: We report that an average of 15% of patients with electrolyte abnormalities develop renal toxicity and reduced function. Moreover, electrolytes may serve as an early indicator for renal damage as part of chemotherapy complication. This indication represents 15% of renal toxicity cases. Changes in electrolyte levels have been reported with cisplatin. Specifically, it has been linked to hypomagnesemia, hypocalcemia and hypokalemia. This study will help reduce the risk of dialysis or the need for kidney transplant. It is also important to manage any underlying conditions and control patients' intake of electrolyt...
Source: Cancer Control - May 27, 2023 Category: Cancer & Oncology Authors: Bahauddeen M Alrfaei Abdulaziz O Almutairi Alaa A Aljohani Hajar Alammar Abdulaziz Asiri Yahya Bokhari Feda S Aljaser Manal Abudawood Majed Halwani Source Type: research
High cancer selectivity and improving drug release from mesoporous silica nanoparticles in the presence of human serum albumin in cisplatin, carboplatin, oxaliplatin, and oxalipalladium treatment
Eur J Pharm Sci. 2023 May 22:106477. doi: 10.1016/j.ejps.2023.106477. Online ahead of print.ABSTRACTIn this project, drug release was examined based on the adsorption of cisplatin, carboplatin, oxaliplatin, and oxalipalladium on aminated mesoporous silica nanoparticles (N-HMSNs) and human serum albumin (HSA). These compounds were characterized by different techniques where three clinical Pt-drugs, cisplatin, carboplatin, oxaliplatin, plus oxalipalladium were loaded and investigated for release. Based on loading analysis, the loading ability of the mentioned metallodrug on N-HMSNs was dependent on the nature of the drug str...
Source: European Journal of Pharmaceutical Sciences - May 24, 2023 Category: Drugs & Pharmacology Authors: Mahboube Eslami Moghadam Maryam Sadeghi Hassan Mansouri-Torshizi Maryam Saidifar Source Type: research
A Single Center Experience With Bilateral Wilms Tumor
CONCLUSION: Management of BWT varies regarding the use of pre-operative biopsy, neoadjuvant chemotherapy, and extent of disease resection. Further guidelines on treatment protocols may optimize outcomes in children with BWT.PMID:37208897 | DOI:10.1177/00031348231175446
Source: The American Surgeon - May 20, 2023 Category: Surgery Authors: Stephanie Y Chen William Gh Lee Eric Laifman Shale J Mack Shengmei Zhou Eugene S Kim Source Type: research
Model-Informed Precision Dosing of Vancomycin in Adult Patients Undergoing Hemodialysis
In conclusion, this study demonstrated that KoA-predicted hemodialysis clearance may lead to an upgrade from conventional dosing to MIPD for vancomycin in patients undergoing hemodialysis.PMID:37195225 | DOI:10.1128/aac.00089-23
Source: Antimicrobial Agents and Chemotherapy - May 17, 2023 Category: Microbiology Authors: Kazutaka Oda Hirofumi Jono Hideyuki Saito Source Type: research
Nephro-oncology: clinical and biochemical aspects of kidney disease and cancer
This article focuses on acute kidney injury (AKI), chronic kidney disease (CKD), various electrolyte and acid-base disorders, the most common cancers after kidney transplantation and the kidney disorders associated with HSCT (hematopoietic stem cell transplantation). The possibility of the application of novel cancer therapy, such as cancer immunotherapy and proton therapy in transplant recipients was also discussed.PMID:37159995 | DOI:10.18388/abp.2020_6588
Source: Acta Biochim Pol - May 9, 2023 Category: Biochemistry Authors: Slawomir Lizakowski Alicja D ębska-Ślizień Ilona Kurnatowska Maciej Jan Zaucha Marcin Matuszewski Beata Naumnik Marcin Adamczak Jerzy Chudek Magdalena Durlik Carla Ferr ándiz-Pulido Bartosz Foroncewicz Ryszard Gellert Magdalena Krajewska Micha ł Nowi Source Type: research
Withdrawal from Hemodialysis in a Patient with IgD Type Multiple Myeloma: A Case-based Review
Acta Med Okayama. 2023 Apr;77(2):221-225. doi: 10.18926/AMO/65154.ABSTRACTSeveral previous case reports have shown that patients with immunoglobulin D (IgD) multiple myeloma (MM) can be withdrawn from hemodialysis, however, the characteristics that can predict withdrawal in these patients have not yet been elucidated. A 57-year-old Japanese woman required hemodialysis because of renal dysfunction due to IgD-λ and Bence Jones protein-λ MM. Bortezomib-based chemotherapy nine days after admission led to her withdrawal from hemodialysis on Day 50. In our case-based review, younger age and early initiation of bortezomib-based...
Source: Acta Med Okayama - April 24, 2023 Category: Universities & Medical Training Authors: Hiroki Iriyoshi Ken-Ei Sada Atsushi Miyauchi Hirotaka Yamamoto Daisuke Hashimoto Shigeru Nojima Shingo Yamanaka Masafumi Kawamura Satoshi Oka Source Type: research
