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Therapy: Corticosteroid Therapy

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Total 30301 results found since Jan 2013.

A Randomized Controlled Trial of Corticosteroids in Pediatric Septic Shock: A Pilot Feasibility Study*
Conclusions: This study suggests that a large randomized controlled trial on early use of corticosteroids in pediatric septic shock is potentially feasible. However, the frequent use of empiric corticosteroids in otherwise eligible patients remains a significant challenge. Knowledge translation activities, targeted recruitment, and alternative study designs are possible strategies to mitigate this challenge.
Source: Pediatric Critical Care Medicine - June 1, 2017 Category: Pediatrics Tags: Feature Articles Source Type: research

Glucocorticoid Receptor Polymorphisms and Outcomes in Pediatric Septic Shock*
Conclusions: Based on these glucocorticoid receptor polymorphisms, we could not detect a beneficial effect of corticosteroids among any genotype group. Among children homozygous for the wild-type allele, corticosteroids were independently associated with increased odds of poor outcome.
Source: Pediatric Critical Care Medicine - April 1, 2017 Category: Pediatrics Tags: Feature Articles Source Type: research

Characterization of the Glucocorticoid Receptor in Children Undergoing Cardiac Surgery*
Conclusions: Increasing glucocorticoid receptor levels in peripheral WBCs of children undergoing cardiac surgery are associated with a longer time to being inotrope free. Cortisol levels minimally increased during the study duration. These results suggest that exposure to high-dose perioperative corticosteroids may suppress the hypothalamic-pituitary-adrenal axis leading to increase in glucocorticoid receptor levels in response to a low cortisol environment. Further studies are required to better delineate the interplay between glucocorticoid receptor levels, cortisol levels, corticosteroid exposure, and postoperative in...
Source: Pediatric Critical Care Medicine - August 1, 2018 Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research

Measurement of the glucocorticoid receptor: Relevance to the diagnosis of critical illness–related corticosteroid insufficiency in children
This article details the role of the GR during critical illness with a focus upon the measurement of the GR, as a potentially important means by which to clinically assess the level of corticosteroid tissue–resistant in patients suspected of CIRCI. Measurement of the GR may be particularly useful as a means by which to determine the judicious administration of steroids, maximizing their therapeutic potential, whereas minimizing the morbidity that can be associated with their use.
Source: Journal of Critical Care - March 3, 2014 Category: Intensive Care Authors: Rahul Bhatia, Jonathan Muraskas, Linda Witek Janusek, Herbert Mathews Tags: Electronic Articles Source Type: research

Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part II): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017
No abstract available
Source: Critical Care Medicine - December 19, 2017 Category: Emergency Medicine Tags: Special Article Source Type: research

Epstein-Barr virus infection-Related hemophagocytic lymphohistiocytosis
We report a case of 27-year-old female diagnosed with hemophagocytic lymphohistiocytosis (HLH) following a recent Epstein-Barr virus (EBV) infection. A known case of relapsing remitting multiple sclerosis on corticosteroids for last 6 months presented to the critical care unit with fever, maculopapular rash and difficulty in breathing. A rapid and correct diagnosis with the precise treatment led to complete recovery of this patient. The HLH is a rare complication of primary EBV infection.
Source: Indian Journal of Critical Care Medicine - July 8, 2015 Category: Intensive Care Authors: Navin KumarChitra MehtaSmita SarmaSumit SinghYatin Mehta Source Type: research

Clinical management practices of life-threatening asthma: an audit of practices in intensive care.
CONCLUSION: In LTA, practice variation is common, with opportunities to improve discharge management plans and asthma education. PMID: 30857513 [PubMed - in process]
Source: Critical Care and Resuscitation - March 13, 2019 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Role of presepsin compared to C-reactive protein in sepsis diagnosis and prognostication
Publication date: Available online 16 February 2017 Source:The Egyptian Journal of Critical Care Medicine Author(s): Mohamed El-Saied El-Shafie, Khaled M. Taema, Moataz M. El-Hallag, Abdallah Mohamed Abdallah Kandeel Early identification of sepsis and its differentiation from non-infective SIRS are important for sepsis outcome. We intended to evaluate the use of presepsin in differentiating sepsis from noninfectious SIRS and its prognostic value compared to CRP. We included 31 patients (median age 60year old, 16 males) admitted with SIRS to El-Sahel Teaching Hospital, Egypt after excluding 21 patients with preadmission co...
Source: The Egyptian Journal of Critical Care Medicine - February 16, 2017 Category: Intensive Care Source Type: research

A pilot study of nebulized heparin for prevention of ventilator induced lung injury: Comparative effects with an inhaled corticosteroid
Conclusion: The results of this study show that the overall effectiveness of nebulized heparin is at least as comparable with a potent corticosteroid (budesonide). Heparin could be a safe and effective modality for patients who at risk of VILI.
Source: Indian Journal of Critical Care Medicine - October 17, 2017 Category: Intensive Care Authors: Farzin Ghiasi Mohsen Sadeghian Mohammad Emami Babak Ali Kiaie Sarah Mousavi Source Type: research

Corticosteroid Therapy for Critically Ill Patients with the Middle East Respiratory Syndrome.
CONCLUSIONS: Corticosteroid therapy in patients with MERS was not associated with a difference in mortality after adjustment for time-varying confounders, but was associated with delayed MERS coronavirus RNA clearance. These findings highlight the challenges and importance of adjusting for baseline and time-varying confounders when estimating clinical effects of treatments using observational studies. PMID: 29161116 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - November 21, 2017 Category: Respiratory Medicine Authors: Arabi YM, Mandourah Y, Al-Hameed F, Sindi AA, Al Mekhlafi GA, Hussein MA, Jose J, Pinto R, Al-Omari A, Kharaba A, Almotairi A, Al Khatib K, Alraddadi B, Shalhoub S, Abdulmomen A, Qushmaq I, Mady A, Solaiman O, Al-Aithan AM, Al-Raddadi R, Ragab A, Balkhy H Tags: Am J Respir Crit Care Med Source Type: research

Major publications in critical care pharmacotherapy literature in 2018
ConclusionThis clinical review and expert commentary of impactful critical care pharmacotherapy publications in 2018 provides perspectives and insights for the critical care practitioner.
Source: Journal of Critical Care - May 2, 2019 Category: Gastroenterology Source Type: research

Disease Management Plus Recommended Care versus Recommended Care Alone for Ambulatory COPD Patients.
CONCLUSIONS: DM added to RC was not superior to RC alone in delaying first hospital admission or death among ambulatory COPD patients. Clinical trial registration available at www.clinicaltrials.gov, ID NCT00982384. PMID: 29494211 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - March 1, 2018 Category: Respiratory Medicine Authors: Kalter-Leibovici O, Benderly M, Freedman LS, Kaufman G, Molcho Falkenberg Luft T, Murad H, Olmer L, Gluch M, Segev D, Gilad A, Elkrinawi S, Cukierman-Yaffe T, Chen B, Jacobson O, Key C, Shani M, Fink G, Chronic Obstructive Pulmonary Disease Community Dise Tags: Am J Respir Crit Care Med Source Type: research

A Canadian survey of critical care physicians' hemodynamic management of deceased organ donors.
CONCLUSION: We observed important variability in self-perceived practices of ICU physicians in the hemodynamic management of deceased donors, particularly in the treatment of the autonomic storm, in the prescription of hormone therapy, and in the administration of inotropes. PMID: 31168739 [PubMed - as supplied by publisher]
Source: Canadian Journal of Anaesthesia - June 4, 2019 Category: Anesthesiology Authors: Frenette AJ, Charbonney E, D'Aragon F, Serri K, Marsolais P, Chassé M, Meade M, Williamson D, Canadian Critical Care TrialsGroup Tags: Can J Anaesth Source Type: research

What Is the Right Dose of Systemic Corticosteroids for Intensive Care Unit Patients with Chronic Obstructive Pulmonary Disease Exacerbations?. A Question in Search of a Definitive Answer.
PMID: 24787061 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - May 1, 2014 Category: Respiratory Medicine Authors: Abroug F, Krishnan JA Tags: Am J Respir Crit Care Med Source Type: research

Steroids in CAP: Beneficial, Harmful, or Inconsequential?Steroids in CAP: Beneficial, Harmful, or Inconsequential?
A meta-analysis examines the question of whether corticosteroids are of any use in adults hospitalized with community-acquired pneumonia. Medscape Critical Care
Source: Medscape Critical Care Headlines - January 26, 2016 Category: Intensive Care Tags: Critical Care Viewpoint Source Type: news