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COVID-19 Can Cause New Cholesterol Problems. What to Know
Not long after the start of the global coronavirus pandemic, it was apparent that many people infected with SARS-CoV-2 were developing persistent and, in some cases, debilitating health problems. Now known widely as post-Covid syndrome or Long COVID, the most common symptoms of this condition are fatigue, attention problems, headaches, muscle or joint pain, and weakness. But those are just the start. Medical researchers have also linked SARS-CoV-2 to lingering complications in multiple organs and systems, and some recent work has found that new-onset cholesterol problems may be an under-recognized but common complication o...
Source: TIME: Health - May 30, 2023 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized healthscienceclimate heart health Source Type: news

Janssen Submits New Drug Application to U.S. FDA Seeking Approval of Investigational Single Tablet Combination Therapy of Macitentan and Tadalafil for Treatment of Patients with Pulmonary Arterial Hypertension (PAH)
RARITAN, NJ, May 30, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the submission of a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) seeking approval of an investigational single tablet combination therapy of macitentan 10mg and tadalafil 40mg (M/T STCT) for the long-term treatment of pulmonary arterial hypertension (PAH, World Health Organization [WHO] Group 1) in adult patients with WHO functional class (FC) II-III.[1] The application is based on positive data from the Phase 3 A DUE study, which met its primary endpoint and demonstrated that M/T STCT si...
Source: Johnson and Johnson - May 30, 2023 Category: Pharmaceuticals Source Type: news

Predictive Attributes for Developing Long COVID-A Study Using Machine Learning and Real-World Data from Primary Care Physicians in Germany
Conclusions: The present exploratory study describes an initial investigation of the prediction of potential features increasing the risk of developing long COVID after COVID-19 infection by using the patient history from electronic medical records before COVID-19 infection in primary care practices in Germany using machine learning. Notably, we identified several predictive features for the development of long COVID in patient demographics and their medical histories.PMID:37240616 | PMC:PMC10219004 | DOI:10.3390/jcm12103511
Source: Pain Physician - May 27, 2023 Category: Anesthesiology Authors: Roman Kessler Jos Philipp Joanna Wilfer Karel Kostev Source Type: research

Randomized trial to evaluate the safety, tolerability, and immunogenicity of a booster (third dose) of BNT162b2 COVID-19 vaccine coadministered with 20-valent pneumococcal conjugate vaccine in adults  ≥65 years old
CONCLUSIONS: Safety and immunogenicity of coadministered PCV20 and BNT162b2 were similar to those of PCV20 or BNT162b2 administered alone, suggesting that the 2 vaccines may be coadministered.TRIAL REGISTRATION: ClinicalTrials.gov, NCT04887948.PMID:37244809 | PMC:PMC10165018 | DOI:10.1016/j.vaccine.2023.05.002
Source: Vaccine - May 27, 2023 Category: Allergy & Immunology Authors: David Fitz-Patrick Mariano Young Kari Yacisin Kathleen McElwee Todd Belanger Kelly Belanger Yahong Peng Dung-Yang Lee William C Gruber Daniel A Scott Wendy Watson Source Type: research

Predictive Attributes for Developing Long COVID-A Study Using Machine Learning and Real-World Data from Primary Care Physicians in Germany
Conclusions: The present exploratory study describes an initial investigation of the prediction of potential features increasing the risk of developing long COVID after COVID-19 infection by using the patient history from electronic medical records before COVID-19 infection in primary care practices in Germany using machine learning. Notably, we identified several predictive features for the development of long COVID in patient demographics and their medical histories.PMID:37240616 | DOI:10.3390/jcm12103511
Source: Pain Physician - May 27, 2023 Category: Anesthesiology Authors: Roman Kessler Jos Philipp Joanna Wilfer Karel Kostev Source Type: research

Adverse Effects Post Covid -19 Vaccination and Its Association with Age, Gender and Comorbid Disease in Basrah City Southern of Iraq
CONCLUSION: Most adverse effects related to the COVID-19 vaccine were minor and could be tolerated without the need for hospital admission.PMID:37231751 | DOI:10.2174/1574886318666230525142152
Source: Current Drug Safety - May 26, 2023 Category: Drugs & Pharmacology Authors: Zainab Najim Abdul-Nabi Noor Kadhim Mohamed-Jawad Noor Yousif Fareed Nadheerah Falih Neama Falah Hassan Shari Source Type: research

News at a glance: China ’s ethics oversight, ARPA-H’s new science, and $210 million for protein research
PUBLIC HEALTH FDA advisers back maternal RSV shot A vaccine aims to protect infants from respiratory syncytial virus, a leading cause of infant hospitalization. JAMIE KELTER DAVIS/ THE NEW YORK TIMES /REDUX A panel advising the U.S. Food and Drug Administration (FDA) last week recommended that it approve a vaccine given to pregnant people to protect infants from respiratory syncytial virus (RSV), which can cause severe lung infections. The vote was unanimous based on the efficacy of the vaccine, called RSVpreF and branded Abrysvo. Ten members of the panel also...
Source: Science of Aging Knowledge Environment - May 25, 2023 Category: Geriatrics Source Type: research

Prevalence and difference of COVID-19 symptoms, post-COVID conditions and duration of illness among the vaccinated and unvaccinated population: a cross-sectional study in Peshawar
CONCLUSION: The study found that COVID-19 vaccination can reduce the duration and frequency of symptoms, as well as post-COVID conditions. This is the first research of its kind conducted in Peshawar, Pakistan, and may serve as a foundation for future research in this demographic.PMID:37229071 | PMC:PMC10205198 | DOI:10.1097/MS9.0000000000000606
Source: Annals of Medicine - May 25, 2023 Category: Internal Medicine Authors: Asad Rahman Muhammad T Ikram Amina Arif Bakht D Khan Kamal U Azam Muhammad Sanaan Fida Adam K Rahim Muhammad S Khan Muhammad H Mushtaq Raiyan Fida Hamza Yunus Mohammad D Khan Source Type: research