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Specialty: Allergy & Immunology
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Total 72221 results found since Jan 2013.
Avian safety guardian: Luteolin restores Mycoplasma gallisepticum-induced immunocompromise to improve production performance via inhibiting the IL-17/NF-kB pathway
This study indicates Lut can serve as a safe and effective antibiotic alternative drug for preventing and treating MG-induced CRD. It also provides new evidence to explore the molecular mechanisms of MG infection.PMID:37717315 | DOI:10.1016/j.intimp.2023.110946
Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Tengfei Wang Guangyang Jiang Shan Lv Yufei Xiao Changyong Fan Mengyun Zou Yingjie Wang Qiao Guo Md Ahsanul Kabir Xiuli Peng Source Type: research
Brevilin A attenuates cartilage destruction in osteoarthritis mouse model by inhibiting inflammation and ferroptosis via SIRT1/Nrf2/GPX4 signaling pathway
In conclusion, brevilin A protected mice against OA via suppressing inflammatory response and ferroptosis by regulating SIRT1/Nrf2/GPX4 signaling.PMID:37717314 | DOI:10.1016/j.intimp.2023.110924
Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Qing Ruan Cuijie Wang Yunfeng Zhang Jiayang Sun Source Type: research
cGAS-like receptors: back to the future
Trends Immunol. 2023 Sep 11:S1471-4906(23)00177-1. doi: 10.1016/j.it.2023.08.009. Online ahead of print.ABSTRACTRecent studies have characterized ancient forms of cyclic GMP-AMP (cGAMP) synthase (cGAS)-like receptors (cGLRs) in bacterial and Drosophila immunity. Using bioinformatics and biochemical screening, Li et al. recently constructed and characterized >3000 cGLRs to reveal conserved mechanisms of nucleic acid sensing across animal immunity.PMID:37718174 | DOI:10.1016/j.it.2023.08.009
Source: Trends in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Fiachra Humphries Source Type: research
The diversity of cGLR receptors: shedding new light on innate immunity
Trends Immunol. 2023 Sep 12:S1471-4906(23)00181-3. doi: 10.1016/j.it.2023.09.001. Online ahead of print.ABSTRACTThe characterization of a new group of innate pattern recognition receptors detected in >500 species across the tree of life by Li et al. reveals surprising commonalities and peculiarities shared with other innate receptors. Receptor diversity within and among species opens the way to reconsidering the costs and benefits of innate immune recognition.PMID:37718173 | DOI:10.1016/j.it.2023.09.001
Source: Trends in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: C Jessica E Metcalf Alexander E Downie Source Type: research
Active inoculation with an inactivated Coxsackievirus A2 vaccine induces neutralizing antibodies and protects mice against lethal infection
In conclusion, our findings suggest that this experimental inactivated CVA2 vaccine is a promising component of polyvalent vaccines related to HFMD in the near future.PMID:37718187 | DOI:10.1016/j.vaccine.2023.08.083
Source: Vaccine - September 17, 2023 Category: Allergy & Immunology Authors: Yuexia Wang Wangquan Ji Dong Li Tiantian Sun Peiyu Zhu Junwei Li Liang Zhang Yu Zhang Haiyan Yang Shuaiyin Chen Yuefei Jin Guangcai Duan Source Type: research
Protocol for a living evidence synthesis on variants of concern and COVID-19 vaccine effectiveness
DISCUSSION: Evidence generated from our living evidence synthesis will be used to inform policy making, modelling, and prioritization of future research on the effectiveness of COVID-19 vaccines against VOC.PMID:37718186 | DOI:10.1016/j.vaccine.2023.09.012
Source: Vaccine - September 17, 2023 Category: Allergy & Immunology Authors: Nicole Shaver Melanie Katz Gideon Darko Asamoah Lori-Ann Linkins Wael Abdelkader Andrew Beck Alexandria Bennett Sarah E Hughes Maureen Smith Mpho Begin Doug Coyle Thomas Piggott Benjamin M Kagina Vivian Welch Caroline Colijn David J D Earn Khaled El Emam Source Type: research
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research
Targeting C5a is beneficial in critically ill COVID-19 patients
Immunobiology. 2023 Sep 12;228(6):152743. doi: 10.1016/j.imbio.2023.152743. Online ahead of print.NO ABSTRACTPMID:37717470 | DOI:10.1016/j.imbio.2023.152743
Source: Immunobiology - September 17, 2023 Category: Allergy & Immunology Authors: Endry H T Lim Alexander P J Vlaar Matthijs C Brouwer Diederik van de Beek Source Type: research
DNA methylation profiling and integrative multi-omics analysis of skin samples reveal important contribution of epigenetics and immune response in the pathogenesis of acne vulgaris
This study supports the significant contribution of epigenetics to the pathogenesis of acne vulgaris and may provide new ideas for the molecular mechanisms of and potential therapeutic strategies for acne vulgaris.PMID:37717673 | DOI:10.1016/j.clim.2023.109773
Source: Clinical Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Lin Liu Yuzhou Xue Jiayi Chen Yuxin Li Tingqiao Chen Xingyu Pan Judan Zhong Xinyi Shao Yangmei Chen Jin Chen Source Type: research
MAIT cells confer resistance to Lenvatinib plus anti-PD1 antibodies in hepatocellular carcinoma through TNF-TNFRSF1B pathway
Clin Immunol. 2023 Sep 15:109770. doi: 10.1016/j.clim.2023.109770. Online ahead of print.ABSTRACTThe combination of antiangiogenic agents and immune checkpoint inhibitors is more efficient than monotherapy in the management of hepatocellular carcinoma (HCC). Lenvatinib plus anti-PD1 antibodies have become the mainstay in HCC treatment. However, more than half the patients with HCC are non-responsive, and the mechanisms underlying drug resistance are unknown. To address this issue, we performed single-cell sequencing on samples from six HCC patients, aiming to explore cellular signals and molecular pathways related to the e...
Source: Clinical Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Cheng Zhou Bao-Ye Sun Pei-Yun Zhou Zhang-Fu Yang Zhu-Tao Wang Gao Liu Wei Gan Zheng Wang Jian Zhou Jia Fan Yong Yi Ning Ren Shuang-Jian Qiu Source Type: research
Better safe than sorry: Naive T-cell dynamics in healthy ageing
Semin Immunol. 2023 Sep 14;70:101839. doi: 10.1016/j.smim.2023.101839. Online ahead of print.ABSTRACTIt is well-known that the functioning of the immune system gradually deteriorates with age, and we are increasingly confronted with its consequences as the life expectancy of the human population increases. Changes in the T-cell pool are among the most prominent features of the changing immune system during healthy ageing, and changes in the naive T-cell pool in particular are generally held responsible for its gradual deterioration. These changes in the naive T-cell pool are thought to be due to involution of the thymus. I...
Source: Seminars in Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Rob J de Boer Kiki Tesselaar Jos é A M Borghans Source Type: research
Procalcitonin is elevated in severe malaria and is a promising biomarker of severe malaria and multi-organ dysfunction: A cross-sectional study and meta-analysis
CONCLUSIONS: PCT is elevated in P. falciparum-infected patients and could be a good biomarker for diagnosis of severe malaria and multi-organ dysfunction. It can help in the management of severe disease with additional treatment options.PMID:37716164 | DOI:10.1016/j.intimp.2023.110923
Source: International Immunopharmacology - September 16, 2023 Category: Allergy & Immunology Authors: Rina Tripathy Bidyut K Das Aditya K Panda Source Type: research
The effect of artesunate to reverse CLP-induced sepsis immunosuppression mice with secondary infection is tightly related to reducing the apoptosis of T cells via decreasing the inhibiting receptors and activating MAPK/ERK pathway
Int Immunopharmacol. 2023 Sep 14;124(Pt A):110917. doi: 10.1016/j.intimp.2023.110917. Online ahead of print.ABSTRACTT cells play an important role in regulating immune system balance. Sepsis-associated immunosuppression causes apoptosis of T cells and a decrease in their number. Previously, artesunate was found to have an immunomodulatory effect on immunosuppression in model mice with cecal ligation and puncture (CLP)-induced sepsis. In the present study, mouse sepsis models of CLP and CLP with secondary infection were established and treated with artesunate in order to examine the effect of artesunate on adaptive immune r...
Source: International Immunopharmacology - September 16, 2023 Category: Allergy & Immunology Authors: Yue Yuan Ling Hua Jun Zhou Dan Liu Fumin Ouyang Xuemin Chen Shujuan Long Yasi Huang Xin Liu Jiang Zheng Hong Zhou Source Type: research
PR-957 retards rheumatoid arthritis progression and inflammation by inhibiting LMP7-mediated CD4 < sup > + < /sup > T cell imbalance
CONCLUSION: PR-957 ameliorates RA progression and inflammation by repressing LMP7-mediated CD4+ T cell imbalance.PMID:37716163 | DOI:10.1016/j.intimp.2023.110860
Source: International Immunopharmacology - September 16, 2023 Category: Allergy & Immunology Authors: Qingyang Liu Jin Shen Jian Wang Jinjun Xia Jian Yin Guowei Cheng Ximing Qian Yun Jiang Xin Ge Qiubo Wang Source Type: research
Therapeutic potential of ozone water treatment in alleviating atopic dermatitis symptoms in mouse models: Exploring its bactericidal and direct anti-inflammatory properties
This study aimed to verify the bactericidal effects of ozone water at different concentrations (3 and 11 mg/L) against staphylococcal species in vitro, as well as evaluate the anti-inflammatory effects of ozone water in a mouse model of AD and pyoderma. Initially, the bactericidal properties of several concentrations of ozone water were confirmed with Staphylococcus aureus and methicillin-resistant S. pseudintermedius. Both 3 and 11 mg/L of ozone water exhibited a significant bactericidal effect against staphylococci at less than 100 times dilution. We next examined the cellular cytotoxicity and cytokine production (Interl...
Source: International Immunopharmacology - September 16, 2023 Category: Allergy & Immunology Authors: Mao Kaneki Chiharu Ohira Miyu Takahashi Naoki Iwashita Yoshiichi Takagi Masaki Nagane Jumpei Uchiyama Tomoki Fukuyama Source Type: research
