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Total 13617 results found since Jan 2013.
GLUT5: structure, functions, diseases and potential applications
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 7. doi: 10.3724/abbs.2023158. Online ahead of print.ABSTRACTGlucose transporter 5 (GLUT5) is a membrane transporter that specifically transports fructose and plays a key role in dietary fructose uptake and metabolism. In recent years, a high fructose diet has occupied an important position in the daily intake of human beings, resulting in a significant increase in the incidence of obesity and metabolic diseases worldwide. Over the past few decades, GLUT5 has been well understood to play a significant role in the pathogenesis of human digestive diseases. Recently, the role of GL...
Source: Acta Biochimica et Biophysica Sinica - September 7, 2023 Category: Biochemistry Authors: Aqian Song Yuanpeng Mao Hongshan Wei Source Type: research
The Relationship Between Taste and Smell Alterations and Quality of Life Among Women With Breast Cancer Receiving Chemotherapy
Oncol Nurs Forum. 2023 Jun 15;50(4):499-508. doi: 10.1188/23.ONF.499-508.ABSTRACTOBJECTIVES: To understand taste and smell alterations (TSAs) and their relationship with quality of life among women with breast cancer receiving chemotherapy.SAMPLE & SETTING: A descriptive correlational study was conducted with 121 women with breast cancer receiving chemotherapy, and data were collected through an online survey.METHODS & VARIABLES: The Taste and Smell Survey was used to measure TSAs, and the Functional Assessment of Cancer Therapy-Breast was used to measure quality of life.RESULTS: More than half of the participants ...
Source: Oncology Nursing Forum - September 7, 2023 Category: Nursing Authors: Hae Jeong An Sook Jung Kang Source Type: research
GLUT5: structure, functions, diseases and potential applications
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 7. doi: 10.3724/abbs.2023158. Online ahead of print.ABSTRACTGlucose transporter 5 (GLUT5) is a membrane transporter that specifically transports fructose and plays a key role in dietary fructose uptake and metabolism. In recent years, a high fructose diet has occupied an important position in the daily intake of human beings, resulting in a significant increase in the incidence of obesity and metabolic diseases worldwide. Over the past few decades, GLUT5 has been well understood to play a significant role in the pathogenesis of human digestive diseases. Recently, the role of GL...
Source: Acta Biochimica et Biophysica Sinica - September 7, 2023 Category: Biochemistry Authors: Aqian Song Yuanpeng Mao Hongshan Wei Source Type: research
The Relationship Between Taste and Smell Alterations and Quality of Life Among Women With Breast Cancer Receiving Chemotherapy
Oncol Nurs Forum. 2023 Jun 15;50(4):499-508. doi: 10.1188/23.ONF.499-508.ABSTRACTOBJECTIVES: To understand taste and smell alterations (TSAs) and their relationship with quality of life among women with breast cancer receiving chemotherapy.SAMPLE & SETTING: A descriptive correlational study was conducted with 121 women with breast cancer receiving chemotherapy, and data were collected through an online survey.METHODS & VARIABLES: The Taste and Smell Survey was used to measure TSAs, and the Functional Assessment of Cancer Therapy-Breast was used to measure quality of life.RESULTS: More than half of the participants ...
Source: Oncology Nursing Forum - September 7, 2023 Category: Nursing Authors: Hae Jeong An Sook Jung Kang Source Type: research
Cancers, Vol. 15, Pages 4450: Morphea, Eosinophilic Fasciitis and Cancer: A Scoping Review
This study is limited by the type of articles included (case reports, case series and observational studies), and hence, additional research on this important topic is needed.
Source: Cancers - September 7, 2023 Category: Cancer & Oncology Authors: Maxine Joly-Chevrier Alexa G élinas Stephanie Ghazal Sarah Moussa Catherine C. McCuaig Maryam Piram Alexandra Mereniuk Ivan V. Litvinov Mohammed Osman Kevin Pehr Elena Netchiporouk Tags: Review Source Type: research
Fight, flight, and freeze!
Cell Metab. 2023 Sep 5;35(9):1493-1495. doi: 10.1016/j.cmet.2023.08.007.ABSTRACTJust like time and tide, embryonic development waits for no man but progresses forcefully to its completion, with just one exception. Diapause is an enigmatic, reversible, dormant halt that protects the developing embryo. Cancer cells have evolved to hijack many useful stem cell capabilities, and diapause is no exception. Recent work has revealed a diapause-like cancer cell state, prompting the quest for its key molecular regulators useful for cancer therapies. The present paper by Sun et al.1 addresses this knowledge gap by revealing a key pla...
Source: Cell Metabolism - September 6, 2023 Category: Cytology Authors: Riya Keshri Julie Mathieu Hannele Ruohola-Baker Source Type: research
Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy
In this study, the PROTAC strategy was used to perform structural modifications of the flavonoid derivative LWT-111 to design a series of flavonoid-based CDK9 degraders. Notably, compound CP-07 emerged as a potent CDK9 degrader, effectively suppressing the proliferation and colony formation of 22RV1 cells by downregulating Mcl-1 and c-Myc. Moreover, CP-07 exhibited significant tumor growth inhibition with a TGI of 75.1% when administered at a dose of 20 mg/kg in the 22RV1 xenograft tumor model. These findings demonstrated the potential of CP-07 as a powerful flavonoid-based CDK9 degrader for prostate cancer therapy.PMID:37...
Source: European Journal of Medicinal Chemistry - September 6, 2023 Category: Chemistry Authors: Tizhi Wu Zhiming Zhang Guangyue Gong Zekun Du Yifan Xu Sixian Yu Feihai Ma Xuan Zhang Yuxiao Wang Haoming Chen Shiqi Wu Xi Xu Zhixia Qiu Zhiyu Li Hongxi Wu Jinlei Bian Jubo Wang Source Type: research
Fight, flight, and freeze!
Cell Metab. 2023 Sep 5;35(9):1493-1495. doi: 10.1016/j.cmet.2023.08.007.ABSTRACTJust like time and tide, embryonic development waits for no man but progresses forcefully to its completion, with just one exception. Diapause is an enigmatic, reversible, dormant halt that protects the developing embryo. Cancer cells have evolved to hijack many useful stem cell capabilities, and diapause is no exception. Recent work has revealed a diapause-like cancer cell state, prompting the quest for its key molecular regulators useful for cancer therapies. The present paper by Sun et al.1 addresses this knowledge gap by revealing a key pla...
Source: Cell Metabolism - September 6, 2023 Category: Cytology Authors: Riya Keshri Julie Mathieu Hannele Ruohola-Baker Source Type: research
Nicotinic acetylcholine receptors in cancer: Limitations and prospects
Biochim Biophys Acta Mol Basis Dis. 2023 Sep 4:166875. doi: 10.1016/j.bbadis.2023.166875. Online ahead of print.ABSTRACTNicotinic acetylcholine receptors (nAChRs) have long been considered to solely mediate neurotransmission. However, their widespread distribution in the human body suggests a more diverse physiological role. Additionally, the expression of nAChRs is increased in certain cancers, such as lung cancer, and has been associated with cell proliferation, epithelial-to-mesenchymal cell transition, angiogenesis and apoptosis prevention. Several compounds that interact with these receptors have been identified as po...
Source: Biochimica et Biophysica Acta - September 6, 2023 Category: Biochemistry Authors: T Bele T Turk I Kri žaj Source Type: research
