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Total 409123 results found since Jan 2013.

Utility of the 2-Nitrobenzenesulfonamide Group as a Chemical Linker for Enhanced Extracellular Stability and Cytosolic Cleavage in siRNA-Conjugated Polymer Systems.
Abstract Herein we report the 2-nitrobenzenesulfonamide group as a new chemical linker that responds to the difference in redox potential across the cellular membrane, toward the construction of siRNA-polymer conjugates. PEG-conjugated to siRNA via the 2-nitrobenzenesulfonamide group (PEG-sul-siRNA) exhibited highly selective siRNA release under intracellular conditions due to the exclusive presence of GSH/GST ratios in the cell. In addition, siRNA release from PEG-sul-siRNA under extracellular reductive conditions was dramatically suppressed relative to PEG-siRNA conjugates containing a conventional redox-sensiti...
Source: ChemMedChem - November 9, 2016 Category: Chemistry Authors: Huang CH, Takemoto H, Nomoto T, Tomoda K, Matsui M, Nishiyama N Tags: ChemMedChem Source Type: research

Gene silencing by 2'-O-methyldithiomethyl-modified siRNA, a prodrug-type siRNA responsive to reducing environment.
Abstract RNAs bearing various 2'-modifications have been synthesized in an effort to improve nuclease resistance. However, the gene silencing activity of small interfering RNAs (siRNAs) has been decreased or sometimes completely suppressed by the chemical modifications. We previously developed a post-synthetic approach for the synthesis of 2'-O-methyldithiomethyl-modified RNA, which can be converted into unmodified RNA under reducing conditions, and named it Reducing-Environment-Dependent Uncatalyzed Chemical Transforming RNA (REDUCT RNA). Here, the gene silencing activity of REDUCT siRNA bearing 2'-O-methyldithio...
Source: Bioorganic and Medicinal Chemistry Letters - December 22, 2015 Category: Chemistry Authors: Ochi Y, Imai M, Nakagawa O, Hayashi J, Wada SI, Urata H Tags: Bioorg Med Chem Lett Source Type: research

Gold-Installed Biostable Nanocomplexes for Tumor-Targeted siRNA Delivery In Vivo
Chem. Commun., 2015, Accepted ManuscriptDOI: 10.1039/C5CC05639J, CommunicationRoun Heo, Hong Yeol Yoon, Hyewon Ko, Jung Min Shin, Jueun Jeon, Yee Soo Chae, Young Mo Kang, Dukjoon Kim, Doo Sung Lee, Jae Hyung ParkThe key issues, associated with nanocarriers for small interfering RNAs (siRNAs), are their poor stability and lack of tumor targetability in vivo. To address these needs, we developed gold-installed polyethyleneimine/siRNA...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 21, 2015 Category: Chemistry Authors: Roun Heo Source Type: research

Highly Efficient Photocontrolled Targeted Delivery of siRNA by a Cyclodextrin-Based Supramolecular Nanoassembly
In this study, we fabricated a binary supramolecular nanoassembly composed of α-cyclodextrin-modified hyaluronic acid and an azobenzene-modified diphenylalanine derivative with a positively charged imidazole group.This nanoassembly can bind with siRNA... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - February 29, 2020 Category: Chemistry Authors: Feng-Qing Li Source Type: research

Evidential significance of automotive paint trace evidence using a pattern recognition based infrared library search engine for the Paint Data Query Forensic Database.
Abstract A prototype library search engine has been further developed to search the infrared spectral libraries of the paint data query database to identify the line and model of a vehicle from the clear coat, surfacer-primer, and e-coat layers of an intact paint chip. For this study, search prefilters were developed from 1181 automotive paint systems spanning 3 manufacturers: General Motors, Chrysler, and Ford. The best match between each unknown and the spectra in the hit list generated by the search prefilters was identified using a cross-correlation library search algorithm that performed both a forward and ba...
Source: Talanta - July 31, 2016 Category: Chemistry Authors: Lavine BK, White CG, Allen MD, Fasasi A, Weakley A Tags: Talanta Source Type: research

Feasibility and desirability of screening search results from Google Search exhaustively for systematic reviews: a cross ‐case analysis
This study aimed to provide further ev idence on the feasibility of screening search results from Google Search exhaustively, and to assess the desirability of this in terms of identifying studies for a systematic review. We conducted a cross-case analysis of the search results of eight Google Search searches from two systematic reviews. Feasibility of exhaustive screening was ascertained by calculating the viewable number of results. Desirability was ascertained according to: (1) the distribution of studies within the results, irrespective of relevance to a systematic review; (2) the distribution of studies which met the ...
Source: Research Synthesis Methods - January 12, 2023 Category: Chemistry Authors: Simon Briscoe, Rebeca Abbott, Hassanat Lawal, Liz Shaw, Jo Thompson Coon Tags: RESEARCH ARTICLE Source Type: research

Text mining for search term development in systematic reviewing: A discussion of some methods and challenges
Using text mining to aid the development of database search strings for topics described by diverse terminology has potential benefits for systematic reviews; however, methods and tools for accomplishing this are poorly covered in the research methods literature. We briefly review the literature on applications of text mining for search term development for systematic reviewing. We found that the tools can be used in 5 overarching ways: improving the precision of searches; identifying search terms to improve search sensitivity; aiding the translation of search strategies across databases; searching and screening within an ...
Source: Research Synthesis Methods - June 1, 2017 Category: Chemistry Authors: Claire Stansfield, Alison O'Mara ‐Eves, James Thomas Tags: ORIGINAL ARTICLE Source Type: research

Visualizing the agreement of peptide assignments between different search engines.
AbstractThere is a trend in the analysis of shotgun proteomics data that aims to combine information from multiple search engines to increase the number of peptide annotations in an experiment. Typically, the degree of search engine complementarity and search engine agreement is visually illustrated by means of Venn diagrams that present the findings of a database search on the level of the non ‐redundant peptide annotations. We argue this practice to be not fit‐for‐purpose since the diagrams do not take into account and often conceal the information on complementarity and agreement at the level of the spectrum ident...
Source: Journal of Mass Spectrometry - November 11, 2019 Category: Chemistry Authors: Annelies Agten, Joris Van Houtven, Manor Askenazi, Tomasz Burzykowski, Kris Laukens, Dirk Valkenborg Tags: SPECIAL ISSUE ‐ RESEARCH ARTICLE Source Type: research

Visualizing the agreement of peptide assignments between different search engines
AbstractThere is a trend in the analysis of shotgun proteomics data that aims to combine information from multiple search engines to increase the number of peptide annotations in an experiment. Typically, the degree of search engine complementarity and search engine agreement is visually illustrated by means of Venn diagrams that present the findings of a database search on the level of the nonredundant peptide annotations. We argue this practice to be not fit ‐for‐purpose since the diagrams do not take into account and often conceal the information on complementarity and agreement at the level of the spectrum identifi...
Source: Journal of Mass Spectrometry - December 2, 2019 Category: Chemistry Authors: Annelies Agten, Joris Van Houtven, Manor Askenazi, Tomasz Burzykowski, Kris Laukens, Dirk Valkenborg Tags: SPECIAL ISSUE ‐ RESEARCH ARTICLE Source Type: research

The ScHARR LMIC filter: adapting a low ‐ and middle‐income countries geographic search filter to identify studies on preterm birth prevention and management
ConclusionWe recommend that the ScHARR LMIC filter is used to improve sensitivity of the Cochrane EPOC LMIC filter and reduce the risk of missing relevant studies.This article is protected by copyright. All rights reserved.
Source: Research Synthesis Methods - February 11, 2022 Category: Chemistry Authors: Anthea Sutton, Fiona Campbell Tags: RESEARCH ARTICLE Source Type: research

Investigation of text ‐mining methodologies to aid the construction of search strategies in systematic reviews of diagnostic test accuracy – a case study
ConclusionsOur findings have implications for the way in which these methodologies are used and applied to search strategies. If semi-automated techniques are to become mainstream in information retrieval for complex systematic reviews, we need tailored tools that fit information specialists ’ requirements across disciplines.This article is protected by copyright. All rights reserved.
Source: Research Synthesis Methods - July 16, 2022 Category: Chemistry Authors: Hannah O'Keefe, Judith Rankin, Sheila A. Wallace, Fiona Beyer Tags: RESEARCH ARTICLE Source Type: research

Locating qualitative studies in dementia on MEDLINE, EMBASE, CINAHL, and PsycINFO: A comparison of search strategies
ConclusionQualitative search strategies using 3 broad terms were more sensitive than long complex searches. The controlled vocabulary for qualitative research in CINAHL was particularly effective. Furthermore, results indicate that MEDLINE and EMBASE offer little benefit for locating qualitative dementia research if CINAHL and PSYCINFO are also searched.
Source: Research Synthesis Methods - November 27, 2017 Category: Chemistry Authors: Morwenna Rogers, Alison Bethel, Rebecca Abbott Tags: SPECIAL ISSUE PAPER Source Type: research

3D-QSAR and docking studies of HIV-1 protease inhibitors using R-group search and Surflex-dock
AbstractIn this paper, a three-dimensional quantitative structure –activity relationships study for 38 HIV-1 protease inhibitors was established using Topomer CoMFA. The multiple correlation coefficients of fitting, cross-validation, and external validation were 0.959, 0.867, and 0.964, respectively. The results indicated that the model obtained has both favorab le estimation stability and good prediction capability. Topomer Search was used to search R-group from ZINC database. As the result, a series of R-groups with relatively high activity contribution was obtained. By No. 32 molecule filtering, 10 Ra and 6 Rb groups ...
Source: Medicinal Chemistry Research - August 9, 2016 Category: Chemistry Source Type: research

Towards a machine-readable literature: finding relevant papers based on an uploaded powder diffraction pattern
A prototype application for machine-readable literature is investigated. The program is called pyDataRecognition and serves as an example of a data-driven literature search, where the literature search query is an experimental data set provided by the user. The user uploads a powder pattern together with the radiation wavelength. The program compares the user data to a database of existing powder patterns associated with published papers and produces a rank ordered according to their similarity score. The program returns the digital object identifier and full reference of top-ranked papers together with a stack plot of the...
Source: Acta Crystallographica Section A - August 19, 2022 Category: Chemistry Authors: Ö zer, B. Karlsen, M.A. Thatcher, Z. Lan, L. McMahon, B. Strickland, P.R. Westrip, S.P. Sang, K.S. Billing, D.G. Ravnsbaek, D.B. Billinge, S.J.L. Tags: machine-readable scientific literature data-driven literature search powder diffraction data similarity CIF research papers Source Type: research