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Total 11974 results found since Jan 2013.

Calcium Phosphate Carrying Simvastatin Enhances Bone Regeneration: A Systematic Review.
In conclusion, the pertinent pre-clinical studies evidenced the calcium phosphate biocompatibility and its effectiveness in delivering SIM to improve the repair of bone defects. So, clinical trials are encouraged to investigate the impact of SIM associated with calcium phosphate bone graft in repairing bone defect in humans. PMID: 32556021 [PubMed - in process]
Source: Braz Dent J - February 29, 2020 Category: Dentistry Authors: Cruz R, Pesce G, Calasans-Maia J, Moraschini V, Calasans-Maia MD, Granjeiro JM Tags: Braz Dent J Source Type: research

Postoperative statin use and risk of biochemical recurrence following radical prostatectomy: Results from the SEARCH database
ConclusionIn this retrospective cohort of men undergoing RP, postoperative statin use was significantly associated with reduced risk of BCR.Whether the association between postoperative statin use and BCR differs by race requires further study.Given these findings, coupled with other studies suggesting that statins may reduce risk of advanced PC, randomized controlled trials are warranted to formally test the hypothesis that statins slow PC progression.
Source: BJU International - March 3, 2014 Category: Urology & Nephrology Authors: Emma H. Allott, Lauren E. Howard, Matthew R. Cooperberg, Christopher J. Kane, William J. Aronson, Martha K. Terris, Christopher L. Amling, Stephen J. Freedland Tags: Urological Oncology Source Type: research

Statin Use, Ageing, and Cognition: A Review
Cholesterol performs a number of important roles in normal brain functioning, including the formation of myelin sheaths and communication between cells, and it has been theorised that statin use could disrupt these roles leading to deficits in cognition. Relevant research was identified via the La Trobe University library SummonTM search tool, using search terms including “statin cognition,” “statins cognition,” “statin brain,” “cholesterol cognition,” “cholesterol brain,” and “statin adverse effects” in addition to examination of the reference lists of the retrieved research articles. Research was ...
Source: Australian Psychologist - May 13, 2016 Category: Psychiatry & Psychology Authors: Nadine E Stephenson, Simon F Crowe Tags: Review Article Source Type: research

Influence of frequently prescribed drugs on bone healing.
CONCLUSION: Data for the effects of the abovementioned pharmacological substances could be found mostly in preclinical studies. The effects of these agents on bone healing in humans has currently not been studied or published. Therefore, the use of these drugs should be discussed carefully in cases with a compromised fracture healing. PMID: 31214745 [PubMed - as supplied by publisher]
Source: Der Unfallchirurg - June 17, 2019 Category: Orthopaedics Authors: Maus U, Maier GS, Lazovic D, Niedhart C Tags: Unfallchirurg Source Type: research

In search of the optimal setting for statin trials in prostate cancer: the power of population-based studies
Prostate Cancer and Prostatic Diseases, Published online: 29 March 2021; doi:10.1038/s41391-021-00355-yIn search of the optimal setting for statin trials in prostate cancer: the power of population-based studies
Source: Prostate Cancer and Prostatic Diseases - March 29, 2021 Category: Urology & Nephrology Authors: Emma H. Allott Emma L. Craig Konrad H. Stopsack Source Type: research

Can Statins Cause Diabetes? - NYTimes.com
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Source: Dr Portnay - July 27, 2016 Category: Cardiology Authors: Dr Portnay Source Type: blogs

The Potential Impact of Statins in the Treatment of Patients with COVID-19 Infection
CONCLUSION: Patients with SARS-CoV-2 infection have a high risk of cardiovascular and thrombotic complications and pleiotropic effects of statins may help manage the COVID-19. There is growing evidence that supports the need for trials of statin treatment in COVID-19 infection.PMID:35132599 | DOI:10.1007/978-3-030-85109-5_9
Source: Atherosclerosis - February 8, 2022 Category: Cardiology Authors: Reza Jafarzadeh Esfehani Mohammad Vojdanparast Saman Soleimanpour Gordon A Ferns Amir Avan Source Type: research

Unreported Drug Side Effects Discovered by Analysis of Google Big Data
Discussion about Big Data; Relevance for Healthcare). The key aspect of such Google research is understanding how to interpret search engine queries. Here's a graph of the search term gonorrhea from Google Trends with volume peaking in October, 2010. A correlation with relevant news headlines is also provided.
Source: Lab Soft News - March 14, 2013 Category: Pathologists Authors: Bruce Friedman Tags: Electronic Medical Record Healthcare Information Technology Medical Consumerism Medical Research Pharmaceutical Industry Source Type: blogs

SLCO1B1 Polymorphisms and Statin-Induced Myopathy
Clinical scenario Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors which reduce the risk of coronary events and death by lowering blood concentrations of low density lipoprotein cholesterol (LDL-c).1,2,3,4 They are generally regarded as safe and well tolerated. However, some patients experience adverse muscle symptoms; these are mostly relatively mild but, in rare cases, severe muscle damage with renal failure (rhabdomyolysis) may occur (reviewed in 5,6). Recently, an autoimmune form of necrotising myositis has also been identified as a rare statin-associated myopathy (reviewed in 7). There ...
Source: PLOS Currents Evidence on Genomic Tests - December 4, 2013 Category: Genetics & Stem Cells Authors: Alison Stewart Source Type: research

Turning PBM " Arbitrage " On Its Head: Bypassing Insurance to Save
The word of the day is " arbitrage " . Officially, Merriam-Webster defines the English language word " arbitrage " this way: " The nearly simultaneous purchase and sale of securities or foreign exchange in different markets in order to profit from price discrepancies " . However, arbitrage does not exclusively apply to securities sold on Wall Street. The term has also been adopted by the Pharmacy Benefit Manager ( " PBM " ) industry. But PBM ' s are not Wall Street investment banks. And that ' s something we all need to realize.The PBM Accountability Project 2021 report " Understanding the Evolving Business Model...
Source: Scott's Web Log - July 25, 2022 Category: Endocrinology Tags: 2022 arbitrage coupon-generating websites apps coupons Medicare PBM Source Type: blogs

IJERPH, Vol. 19, Pages 16736: Burden of Neurological Diseases in the Philippines as Revealed by Web Searches: An Infodemiological Study
This study evaluated the population’s interest in neurological disorders by using search volumes related to neurology, either disease diagnosis or medications. Bid values generated in API were used as a proxy for the interests of the healthcare industry. Spearman’s rank-order correlation was performed between search volumes and bid prices to determine significance. Among the neurologic diseases listed, the most searched were attention deficit hyperactivity disorder, migraine, and Alzheimer’s disease. The most commonly searched drugs were oral antihypertensives (amlodipine, losartan...
Source: International Journal of Environmental Research and Public Health - December 13, 2022 Category: Environmental Health Authors: Anisah Hayaminnah D. Alonto Almira Doreen Abigail O. Apor Roland Dominic G. Jamora Tags: Article Source Type: research

Statins for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.
CONCLUSIONS: Based on the findings of this review, which included two trials with high risk of bias and a small numbers of participants, it seems possible that statins may improve serum aminotransferase levels as well as ultrasound findings. Neither of the trials reported on possible histological changes, liver-related morbidity or mortality. Trials with larger sample sizes and low risk of bias are necessary before we may suggest statins as an effective treatment for patients with NASH. However, as statins can improve the adverse outcomes of other conditions commonly associated with NASH (for example, hyperlipidaemia, diab...
Source: Cochrane Database of Systematic Reviews - December 27, 2013 Category: Journals (General) Authors: Eslami L, Merat S, Malekzadeh R, Nasseri-Moghaddam S, Aramin H Tags: Cochrane Database Syst Rev Source Type: research

Diagnosis, Phenotype, and Molecular Genetics of Congenital Analbuminemia
Conclusion Figure 4 shows that the 27 different molecular defects within the ALB so far reported to cause CAA are located in ten different exons (1, 3, 4, 5, 7, 8, 9, 10, 11, and 12) and in seven different introns (1, 2, 3, 6, 10, 11, and 12) (The Albumin Website, 2018; Caridi et al., 2019). Variations in the last two coding exons (13 and 14) would probably cause the presence of a circulating C-terminal variant of the protein and not CAA. The first twelve exons of ALB, with the exception of the two shortest, exons 2 and 6, were reported to contain at least one molecular defect resulting in CAA (The Albumin Website, 2018; ...
Source: Frontiers in Genetics - April 16, 2019 Category: Genetics & Stem Cells Source Type: research

Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs