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Vaccination: Malaria Vaccine
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Total 1513 results found since Jan 2013.
Isolation, Purification, and Characterization of Homogenous Novel Bioactive Protein from < em > Datura stramonium < /em > Stem Exhibited Larvicidal Activity against < em > Anopheles stephensi < /em >
J Trop Med. 2022 Dec 5;2022:1637896. doi: 10.1155/2022/1637896. eCollection 2022.ABSTRACTThe insecticidal resistance of mosquitoes necessitates the development of a natural, safe, and plant-based method for vector control. Unfortunately, there are no effective vaccines or particular medications available to combat malaria; therefore, mosquitoes must be targeted directly. Previous studies have shown the health benefits of Datura stramonium, but its bioactive peptides or proteins are less explored. This is the first study on D. stramonium stem protein used for mosquito larval protein. The present study aimed to identify the ...
Source: Journal of Tropical Medicine - December 15, 2022 Category: Tropical Medicine Authors: Manisha Kirar S P Singh Neelam Sehrawat Source Type: research
In vitro antimalarial activity of inhibitors of the human GTPase Rac1
Antimicrob Agents Chemother. 2021 Nov 1:AAC0149821. doi: 10.1128/AAC.01498-21. Online ahead of print.ABSTRACTMalaria accounts for millions of cases and thousands of deaths every year. In the absence of an effective vaccine, drugs are still the most important tool in the fight against the disease. Plasmodium parasites developed resistance for all the classes of known antimalarial drugs. Thus, the search for antimalarial drugs with novel mechanisms of action is compelling. The human GTPase Rac1 plays a role in parasite invasion of the host cell in many intracellular pathogens. Also in Plasmodium falciparum, it was suggested ...
Source: Antimicrobial Agents and Chemotherapy - November 1, 2021 Category: Microbiology Authors: Silvia Parapini Silvio Paone Emanuela Erba Loredana Cavicchini Manoochehr Pourshaban Francesco Celani Alessandro Contini Sarah D'Alessandro Anna Olivieri Source Type: research
The immunity modulation of transforming growth factor- β in malaria and other pathological process
Int Immunopharmacol. 2023 Jul 17;122:110658. doi: 10.1016/j.intimp.2023.110658. Online ahead of print.ABSTRACTThe main causative agent of malaria in humans is Plasmodium falciparum, which is spread through biting Anopheles mosquitoes. Immunoregulation in the host involving the pleiotropic cytokine transforming growth factor-β (TGF-β) has a vital role in controlling the immune response to P. falciparum infection. Based on a search of the published literature, this study investigated the correlation between malaria and immune cells, specifically the role of TGF-β in the immune response. The studies analyzed showed that, w...
Source: International Immunopharmacology - July 19, 2023 Category: Allergy & Immunology Authors: Shuang Wu Qing Nie Shuang Tan Guoyan Liao Yinyi Lv Caohua Lv Guang Chen Shuangchun Liu Source Type: research
Indian Court Wants Stricter Clinical Trial Oversight
Amid ongoing concern over the conduct of clinical trials in India and patient protection, the Indian Supreme Court has slammed regulators for shoddy oversight that is creating “havoc” and leading to the deaths of many citizens.
In sharp remarks, the government was criticized for going into a “deep slumber” and failing to establish mechanisms to stop “rackets” of multinational drugmakers, which are allegedly conducting illegal clinical trials around the country, according to various media reports (see here and here).
“There has to be some sense of responsibility (on the part of the government). Hu...
Source: Pharmalot - January 7, 2013 Category: Pharma Commentators Authors: Ed Silverman Tags: Uncategorized Clinical Trials GlaxoSmithKline HPV India Vaccines Source Type: blogs
Prospects of using community directed intervention strategy in delivering health services among Fulani Nomads in Enugu State, Nigeria
Conclusion:
Given the definable organizational structure of the nomads in Enugu State and their desire for modern health intervention, it is feasible to test the CDI strategy for equitable healthcare delivery among nomads. They are willing and capable to participate actively in their own health programmes with minimal support from professional health workers.
Source: International Journal for Equity in Health - April 8, 2013 Category: Global & Universal Authors: Joseph OkeibunorNkechi OnyenehoObioma NwaorguNgozi I¿AronuIjeoma OkoyeFelicia IremekaJohannes Sommerfeld Source Type: research
What is BUKO Pharma-Kampagne?
http://www.en.bukopharma.de/BUKO Pharma-Kampagne was founded with the aim of examining the activities of the German pharmaceutical industry in Third World countries. We want to implement changes by taking special actions and informing the public in detail. Pharma-Kampagne is a campaigning group of the Bundeskoordination Internationalismus(BUKO) (Federal Coordination of Internationalism) uniting 130 German action and solidarity groups working in favour of the Third World. More than 20 years ago, BUKO Pharma-Kampagne started to pay attention to the theme "Drugs and the Third World ". Today it is one of the fe...
Source: PharmaGossip - May 28, 2013 Category: Pharma Commentators Authors: insider Source Type: blogs
U.S. reports malaria vaccine breakthrough
U.S. researchers reported a breakthrough Thursday in the search for a vaccine for malaria, the mosquito-borne disease that sickens millions worldwide.
More than three dozen volunteers received multiple, intravenous doses of a vaccine produced with a ...
Source: WDSU.com - Health - August 11, 2013 Category: Consumer Health News Source Type: news
Inadvertent transfer of a mammalian retrovirus into birds
Reticuloendotheliosis viruses (REVs) are retroviruses that cause a rare disease of gamebirds and waterfowl that includes anemia, immunosuppression, neoplasia, runting, and abnormal feathering. Since the first isolation of REV from a turkey in 1957, REVs were believed to be strictly avian viruses. It now appears that REVs are mammalian viruses that were accidentally introduced into birds in the 1930s during research on malaria.
During an investigation of endogenous retrovirus diversity in Malagasy mammals, the authors found sequences related to REVs in the genomes of the ring-tailed mongoose and the narrow-striped mongoose....
Source: virology blog - August 27, 2013 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information bird fowlpox virus gallid herpesvirus iatrogenic reticuloendotheliosis virus viral Source Type: blogs
