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Type-I like metalloproteinase in the venom of the West African saw-scaled carpet viper (Echis ocellatus) has anti-trypanosomal activity against African trypanosomes
Toxicon. 2023 Apr 29:107138. doi: 10.1016/j.toxicon.2023.107138. Online ahead of print.ABSTRACTAfrican trypanosomiasis is an infectious disease caused by hemoparasites of the genus Trypanosoma and remains a major health problem in Africa - killing around 4000 people and animals worth an estimated $5 billion, annually. The absence of a vaccine and satisfactory drug against African trypanosomiasis (AT) necessitates the continued search for new chemotherapy options. Owing to the rich biochemical diversity in snake venom, it has recently become a source of therapeutic peptides that are being explored for the development of nov...
Source: Toxicon - May 1, 2023 Category: Toxicology Authors: Ameh Ilu Mathias A Chia Thais R Cataldi Carlos A Labate Godwin U Ebiloma Peter O Yusuf Mohammed N Shuaibu Emmanuel O Balogun Source Type: research

Type I-like metalloproteinase in the venom of the West African saw-scaled carpet viper (Echis ocellatus) has anti-trypanosomal activity against African trypanosomes
Toxicon. 2023 Apr 29;229:107138. doi: 10.1016/j.toxicon.2023.107138. Online ahead of print.ABSTRACTAfrican trypanosomiasis is an infectious disease caused by hemoparasites of the genus Trypanosoma and remains a major health problem in Africa - killing around 4000 people and animals worth an estimated $5 billion, annually. The absence of a vaccine and satisfactory drug against African trypanosomiasis (AT) necessitates the continued search for new chemotherapy options. Owing to the rich biochemical diversity in snake venom, it has recently become a source of therapeutic peptides that are being explored for the development of...
Source: Toxicon - May 1, 2023 Category: Toxicology Authors: Ameh Ilu Mathias A Chia Thais R Cataldi Carlos A Labate Godwin U Ebiloma Peter O Yusuf Mohammed N Shuaibu Emmanuel O Balogun Source Type: research

Human monkeypox virus in the shadow of the COVID-19 pandemic
CONCLUSIONS: monkeypox is a viral disease caused by the monkeypox virus (MPXV), which is primarily found in central and western Africa. The disease is transmitted from animals to humans and presents symptoms similar to those of smallpox, including fever, headache, muscle aches, and a rash. Monkeypox can lead to complications such as secondary integument infection, bronchopneumonia, sepsis, and encephalitis, as well as corneal infection that can result in blindness. There is no specific clinically proven treatment for monkeypox, and treatment is primarily supportive. However, antiviral drugs and vaccines are available for c...
Source: Cancer Control - June 3, 2023 Category: Cancer & Oncology Authors: Almu'atasim Khamees Sajeda Awadi Khayry Al-Shami Hayat Abu Alkhoun Sharaf F Al-Eitan Ahmad Malek Alsheikh Ahmad Saeed Raed M Al-Zoubi Mazhar Salim Al Zoubi Source Type: research

Breast and gynecologic cancers as a Brazilian health priority
CONCLUSION: Analyzed together, breast and gynecologic cancers correspond to the leading cause of cancer in Brazil. A heterogeneous group, female cancer includes diseases with a high primary and secondary prevention potential. The organization of a female cancer program in Brazil prioritizing primary and secondary prevention strategies, such as adequate mammography screening and human papillomavirus vaccination coverage, could significantly improve female cancer control in the country.PMID:37556639 | DOI:10.1590/1806-9282.2023S120
Source: Cancer Control - August 9, 2023 Category: Cancer & Oncology Authors: Ang élica Nogueira-Rodrigues Daniela Dornelles Rosa Daniele Assad Suzuki Eduardo Paulino Luciana Castro Garcia Landeiro Mariana Scaranti Marisa Riscalla Madi Paulo Marcelo Hoff Source Type: research

Indian Court Wants Stricter Clinical Trial Oversight
Amid ongoing concern over the conduct of clinical trials in India and patient protection, the Indian Supreme Court has slammed regulators for shoddy oversight that is creating “havoc” and leading to the deaths of many citizens. In sharp remarks, the government was criticized for going into a “deep slumber” and failing to establish mechanisms to stop “rackets” of multinational drugmakers, which are allegedly conducting illegal clinical trials around the country, according to various media reports (see here and here). “There has to be some sense of responsibility (on the part of the government). Hu...
Source: Pharmalot - January 7, 2013 Category: Pharma Commentators Authors: Ed Silverman Tags: Uncategorized Clinical Trials GlaxoSmithKline HPV India Vaccines Source Type: blogs

Stem Cells for Cell-Based Therapies
The world of stem cells We know the human body comprises many cell types (e.g., blood cells, skin cells, cervical cells), but we often forget to appreciate that all of these different cell types arose from a single cell—the fertilized egg. A host of sequential, awe-inspiring events occur between the fertilization of an egg and the formation of a new individual: Embryonic stem (ES) cells are also called totipotent cells. The first steps involve making more cells by simple cell division: one cell becomes two cells; two cells become four cells, etc. Each cell of early development is undifferentiated; that is, it is...
Source: ActionBioscience - December 28, 2012 Category: Science Authors: Ali Hochberg Source Type: news

Pharmalot… Pharmalittle… The Weekend Nears
And so, another working week is about to draw to a close. Not a moment too soon, yes? This is, as you know, our treasured signal to daydream about weekend plans. Our agenda is filled with chores and paperwork, but we do hope to spend time with the short people and catch up on some napping. As for you, anything special planned? You could do something novel, pun intended, and visit your local library, while it still exists. Or hang with a favorite person. And of course, there is always that big football game. Whatever you do, have a grand time, but be safe. See you soon… Merck Delays Filing Of Osteoperosis Drug (Reuter...
Source: Pharmalot - February 1, 2013 Category: Pharma Commentators Authors: Ed Silverman Tags: Uncategorized Amgen Avastin Bristol-Myres Squibb Celsion Dialysis IPO Liver Cancer Medicare Merck Overian Cancer Pfizer Roche TB Tuberculosis Vaccines Zoetis Source Type: blogs

The 30-year fight against HIV
Since its identification as the cause of Aids in 1984, scientists have made major advancements in tackling virus1984 Retrovirus is discovered as cause of Aids and later named human immunodeficiency virus or HIV.1986 Clinical trials show that HIV patients taking AZT (azidothymidine), an antiretroviral drug initially developed as a cancer therapy, were living longer than those who did not. AZT is shown to manage, but not cure, HIV and reduce the rates of mother-to-child infection in pregnancy.1987 The US FDA approves AZT as the first antiretroviral to be used as a treatment for Aids.1995 Jeff Getty, Aids activist, becomes th...
Source: Guardian Unlimited Science - March 3, 2013 Category: Science Authors: Caroline Davies Tags: The Guardian News Health Medical research Aids and HIV Society Source Type: news

Physician Payment Sunshine: ProPublica Database Leads with Disparaging Headlines
Doctor collaborates with industry to conduct lifesaving, breakthrough research.”  “Doctor educates colleagues about safety and clinical date to improve patient outcomes.”  “Physician speaks to peers about new trials that improve patient access to needed drugs.”  “Researchers meet to ensure the success of new clinical trial.”    “Physician invents new medical device that improves cardiovascular health.”  “Industry and physicians collaborate to bring drug to market faster through new approval pathway.”  “Physicians attend education program mandated by FDA under REMS to better understand benef...
Source: Policy and Medicine - April 3, 2013 Category: Health Medicine and Bioethics Commentators Authors: Thomas Sullivan Source Type: blogs

The Media Uses These Powerful Tricks to Condition You to Accept Vaccines
Conclusion The point of this article is to highlight the techniques used by the media, especially using doctors and celebrities to push the pharmaceutical agenda. This tactic certainly can be seen front and center, as there is currently a massive push in the media to deny any link between vaccines and autism. It certainly doesn’t appear much has changed since the 1950s, has it? With that, I’d like to end with two actions I want you to take right now. Download the vaccine ingredients to see what your doctor injects into your child. Watch the explosive documentary on Edward Bernays entitled The Century of Self. ...
Source: vactruth.com - April 6, 2013 Category: Health Medicine and Bioethics Commentators Authors: Jeffry John Aufderheide Tags: Jeffry John Aufderheide Top Stories Carl Byoir Edward Bernays March of Dimes Polio Vaccine propaganda vaccine ingredients Source Type: blogs

Squamous cell carcinomas in patients with Fanconi anemia and dyskeratosis congenita: A search for human papillomavirus
Patients with Fanconi anemia (FA) and dyskeratosis congenita (DC) are at high risk of head and neck squamous cell carcinomas (HNSCC) and anogenital squamous cell carcinomas (SCC). In the general population, these sites (particularly oropharyngeal SCC) may be associated with infection with human papillomavirus (HPV). In FA and DC, however, the majority of HNSCC occur in the oral cavity. We investigated the HPV status of HNSCC and vulvar SCC from nine patients with FA and four with DC using a very sensitive PCR assay, and found HPV16 DNA in only a single vulvar tumor from one patient with FA, and in none of the HNSCC. These ...
Source: International Journal of Cancer - April 5, 2013 Category: Cancer & Oncology Authors: Blanche P. Alter, Neelam Giri, Sharon A. Savage, Wim G.V. Quint, Maurits N.C. Koning, Mark Schiffman Tags: Short Report Source Type: research