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Vaccination: Malaria Vaccine
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Total 1513 results found since Jan 2013.
Infectious diseases in returned travellers, NSW, 2010-2011
CONCLUSION: A large proportion of selected enteric and vectorborne disease case notifications were associated with overseas travel. All potential travellers should be made aware of the risks and available preventive measures, such as vaccination against hepatitis A and typhoid fever, taking precautions with food and water and use of malaria chemoprophylaxis, where appropriate. Improvements in data on risk factors, reason for travel and barriers to the use of preventive measures would better inform prevention strategies.PMID:24939227 | DOI:10.1071/NB13005
Source: New South Wales Public Health Bulletin - June 19, 2014 Category: Health Management Authors: Praveena Gunaratnam Sean Tobin Holly Seale Jeremy M McAnulty Source Type: research
A review of combination adjuvants for malaria vaccines: a promising approach for vaccine development
Int J Parasitol. 2021 Mar 30:S0020-7519(21)00117-X. doi: 10.1016/j.ijpara.2021.01.006. Online ahead of print.ABSTRACTIt is obvious that there is a critical need for an efficient malaria vaccine to accelerate malaria eradication. Currently, recombinant subunit vaccination against malaria using proteins and peptides is gaining attention. However, one of the major drawbacks of this approach is the lack of an efficient and durable immune response. Therefore, subunit vaccines require adjuvants to make the vaccine sufficiently immunogenic. Considering the history of the RTS,S vaccine, it seems likely that no single adjuvant is c...
Source: International Journal for Parasitology - April 2, 2021 Category: Parasitology Authors: Sakineh Pirahmadi Sedigheh Zakeri Navid D Djadid Akram A Mehrizi Source Type: research
Inclusion of an Optimized < em > Plasmodium falciparum < /em > Merozoite Surface Protein 2-Based Antigen in a Trivalent, Multistage Malaria Vaccine
In this study, we exploited the benefits of rPfMSP8 as a carrier to optimize a rPfMSP2-based subunit vaccine. rPfMSP2 and chimeric rPfMSP2/8 vaccines produced in Escherichia coli were evaluated in comparative immunogenicity studies in inbred (CB6F1/J) and outbred (CD1) mice, varying the dose and adjuvant. Immunization of mice with both rPfMSP2-based vaccines elicited high-titer anti-PfMSP2 Abs that recognized the major allelic variants of PfMSP2. Vaccine-induced T cells recognized epitopes present in both PfMSP2 and the PfMSP8 carrier. Competition assays revealed differences in Ab specificities induced by the two rPfMSP2-b...
Source: Journal of Immunology - April 1, 2021 Category: Allergy & Immunology Authors: Jacqueline S Eacret Elizabeth M Parzych Donna M Gonzales James M Burns Source Type: research
Infectious diseases in returned travellers, NSW, 2010-2011
CONCLUSION: A large proportion of selected enteric and vectorborne disease case notifications were associated with overseas travel. All potential travellers should be made aware of the risks and available preventive measures, such as vaccination against hepatitis A and typhoid fever, taking precautions with food and water and use of malaria chemoprophylaxis, where appropriate. Improvements in data on risk factors, reason for travel and barriers to the use of preventive measures would better inform prevention strategies.PMID:24939227 | DOI:10.1071/NB13005
Source: New South Wales Public Health Bulletin - June 19, 2014 Category: Health Management Authors: Praveena Gunaratnam Sean Tobin Holly Seale Jeremy M McAnulty Source Type: research
Variable immunogenicity of a vivax malaria blood-stage vaccine candidate
This study highlights sex and immune genes as critical variables that can impact host responses to P. vivax antigens and must be taken into consideration when designing clinical vaccine studies.PMID:33840564 | DOI:10.1016/j.vaccine.2021.03.072
Source: Vaccine - April 12, 2021 Category: Allergy & Immunology Authors: Sai Lata De Samuel May Keshav Shah Michelle Slawinski Siriruk Changrob Shulin Xu Samantha J Barnes Patchanee Chootong Francis B Ntumngia John H Adams Source Type: research
Non-specific effects of maternal and offspring rabies vaccination on mortality and antibiotic use in a Danish pig herd: A randomized trial
CONCLUSION: The study did not support the hypothesized beneficial NSE of rabies vaccine. Although under-powered for subgroup analyses, the study indicated effect modification by sex and maternal vaccination. Results could be different in a herd with higher mortality and infectious burden.PMID:33840563 | DOI:10.1016/j.vaccine.2021.03.083
Source: Vaccine - April 12, 2021 Category: Allergy & Immunology Authors: Kristoffer Jarlov Jensen Lola Kathe Tolstrup Darryn L Knobel Peter Aaby Gregers Jungersen Lars Erik Larsen Charlotte Sonne Kristensen Christine Stabell Benn Source Type: research
Infectious diseases in returned travellers, NSW, 2010-2011
CONCLUSION: A large proportion of selected enteric and vectorborne disease case notifications were associated with overseas travel. All potential travellers should be made aware of the risks and available preventive measures, such as vaccination against hepatitis A and typhoid fever, taking precautions with food and water and use of malaria chemoprophylaxis, where appropriate. Improvements in data on risk factors, reason for travel and barriers to the use of preventive measures would better inform prevention strategies.PMID:24939227 | DOI:10.1071/NB13005
Source: New South Wales Public Health Bulletin - June 19, 2014 Category: Health Management Authors: Praveena Gunaratnam Sean Tobin Holly Seale Jeremy M McAnulty Source Type: research
Partial protection against P. vivax infection diminishes hypnozoite burden and blood-stage relapses
Cell Host Microbe. 2021 Apr 8:S1931-3128(21)00139-6. doi: 10.1016/j.chom.2021.03.011. Online ahead of print.ABSTRACTLatent forms of Plasmodium vivax, called hypnozoites, cause malaria relapses from the liver into the bloodstream and are a major obstacle to malaria eradication. To experimentally assess the impact of a partially protective pre-erythrocytic vaccine on reducing Plasmodium vivax relapses, we developed a liver-humanized mouse model that allows monitoring of relapses directly in the blood. We passively infused these mice with a suboptimal dose of an antibody that targets the circumsporozoite protein prior to chal...
Source: Cell Host and Microbe - April 15, 2021 Category: Microbiology Authors: Carola Sch äfer Nicholas Dambrauskas Laura M Reynolds Olesya Trakhimets Andrew Raappana Erika L Flannery Wanlapa Roobsoong Jetsumon Sattabongkot Sebastian A Mikolajczak Stefan H I Kappe D Noah Sather Source Type: research
