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Concordance Between Ultra-low Dose (ULD) and Standard Dose CT Scans in the Search for Traumatic Brain Injury
Conditions:   Head Injuries, Penetrating;   Head Injuries, Closed Intervention:   Radiation: Conventional dose AND ultra low-dose CT scanning in the search for cranial lesions Sponsor:   Centre Hospitalier Universitaire de Nīmes Recruiting
Source: ClinicalTrials.gov - June 25, 2021 Category: Research Source Type: clinical trials

Search for a distressed swimmer in a dynamic, real-world environment.
Visual search is increasingly being explored in dynamic, real-world environments. This includes swimming pools, where lifeguards have shown superior drowning detection in simulated environments. Here, we explored if lifeguard superiority is observed in real-life scenes of a busy swimming pool. Experiment 1 required participants to identify real-life distressed swimmers in clips of busy pool activity via a touchscreen interface. Experiment 2 sought to replicate the first study, with the inclusion of eye-movement measures. Experiment 3 varied the methodology, using an occlusion method where clips were frozen and blurred shor...
Source: Journal of Experimental Psychology: Applied - March 22, 2021 Category: Psychiatry & Psychology Source Type: research

Education of general practitioners in the use of point-of-care ultrasonography: a systematic review
ConclusionThere was a large variation in ultrasound training programs for GPs and GPTs, with an overall emphasis on focussed practical training. Few studies included a longitudinal learning process in the training program. However, diagnostic accuracy seemed to improve with hours of practical training, and studies including continuous feedback on scans conducted during clinical patient encounters showed superior results.
Source: Family Practice - December 26, 2020 Category: Primary Care Source Type: research

High-performance nontarget analysis of halogenated organic compounds in tap water, fly ash, soil and sediment using ultrahigh resolution mass spectrometry and scripting approaches based on Cl/Br-specific search algorithms
This study developed a nontarget analysis method for characterization of known and unknown HOCs in tap water, fly ash, soil and sediment using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) with aid of scripting data-processing approaches. The FT-ICR-MS was equipped with an electrospray ionization source operated in negative ion mode, and full scan at a mass resolution around 200,000 was applied. Data screening scripts were developed based on exact mass differences and abundance ratios between neighboring chlorine/bromine isotopologues. Cosine similarity analysis was applied to evaluating similarit...
Source: Analytica Chimica Acta - April 10, 2022 Category: Chemistry Authors: Caiming Tang Guangshi Chen Bin Jiang Jianhua Tan Yutao Liang Hui Lin Yanhong Zeng Xiaojun Luo Bixian Mai Xianzhi Peng Source Type: research

Molecules, Vol. 27, Pages 7336: Homology Modeling and Molecular Dynamics-Driven Search for Natural Inhibitors That Universally Target Receptor-Binding Domain of Spike Glycoprotein in SARS-CoV-2 Variants
Julia Saloni The rapid spread of SARS-CoV-2 required immediate actions to control the transmission of the virus and minimize its impact on humanity. An extensive mutation rate of this viral genome contributes to the virus’ ability to quickly adapt to environmental changes, impacts transmissibility and antigenicity, and may facilitate immune escape. Therefore, it is of great interest for researchers working in vaccine development and drug design to consider the impact of mutations on virus-drug interactions. Here, we propose a multitarget drug discovery pipeline for identifying potential drug candidates w...
Source: Molecules - October 28, 2022 Category: Chemistry Authors: Olha Ovchynnykova Karina Kapusta Natalia Sizochenko Kostyantyn M. Sukhyy Wojciech Kolodziejczyk Glake A. Hill Julia Saloni Tags: Article Source Type: research

OCTA Biomarker Search in Patients with nAMD: Influence of Retinal Fluid on Time-Dependent Biomarker Response
CONCLUSIONS: OCTA-based parameters VA, TVL, TNJ, and MNVarea show a strong response to anti-VEGF therapy over time, independent of the presence of IRF, SRF or RT. We conclude that the above listed OCTA parameters could contribute to our understanding of MNV biology and to guide individualized treatment in the future.TRIAL REGISTRY: The authors confirm that all ongoing and related trials are registered. ClinicalTrials.gov Number: NCT02521142.PMID:36891909 | DOI:10.1080/02713683.2023.2184318
Source: Current Eye Research - March 9, 2023 Category: Opthalmology Authors: Reinhard Told Adrian Reumueller Markus Schranz Jonas Brugger G ünther Weigert Gregor Sebastian Reiter Stefan Sacu Ursula Schmidt-Erfurth Source Type: research

In Search of Calcifications : Histologic Analysis and Diagnostic Yield of Stereotactic Core Needle Breast Biopsies
CONCLUSIONS: We determined the up-to-date detection rates of calcification and DCIS in SCNB, as well as the common benign and malignant breast lesions associated with calcifications. Additional levels significantly increase the detection rate when standard levels show only stromal or scant/absent calcifications. Lobular neoplasia is often an incidental finding in SCNB for calcifications. When calcifications are present with LN, they are commonly florid, pleomorphic LCIS, or with concurrent invasive carcinoma.PMID:37167599 | DOI:10.1093/ajcp/aqad037
Source: Clinical Breast Cancer - May 11, 2023 Category: Cancer & Oncology Authors: Fazilet Yilmaz Sean M Hacking Linda Donegan Lijuan Wang Evgeny Yakirevich Yihong Wang Source Type: research