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Trends in and Characteristics of Buprenorphine Misuse Among Adults in the US
CONCLUSIONS AND RELEVANCE: These findings suggest that among adults with OUD, prevalence of buprenorphine misuse trended downward from 2015 to 2019. In 2019, nearly three-fourths of US adults reporting past-year buprenorphine use did not misuse their prescribed buprenorphine, and most who misused reported using prescription opioids without having their own prescriptions. These findings underscore the need to pursue actions that expand access to buprenorphine-based OUD treatment, to develop strategies to monitor and reduce buprenorphine misuse, and to address associated conditions (eg, suicide risk, co-occurring mental illn...
Source: Pain Physician - October 15, 2021 Category: Anesthesiology Authors: Beth Han Christopher M Jones Emily B Einstein Wilson M Compton Source Type: research
Rural and urban differences in undersupply of buprenorphine provider availability in the United States, 2018
CONCLUSIONS: The rural-urban distribution in undersupply of waivered buprenorphine providers relative to need varied markedly by state. Strategies for improving access to buprenorphine-waivered providers should be state-centric and informed by county-specific indicators of need.PMID:35101112 | PMC:PMC8802270 | DOI:10.1186/s13722-021-00282-2
Source: Addiction Science and Clinical Practice - February 1, 2022 Category: Addiction Authors: Kevin P Conway Dalia Khoury Rainer Hilscher Arnie P Aldridge Stephanie J Parker Gary A Zarkin Source Type: research
A Brief Educational Intervention to Increase ED Initiation of Buprenorphine for Opioid Use Disorder (OUD)
CONCLUSIONS: A brief educational intervention targeting EM clinicians can be utilized to achieve first-time prescribing and improve knowledge around buprenorphine and opioid withdrawal. The use of weekly messaging and gain-framed incentivization conferred no additional benefit to the educational intervention alone. In order to further expand evidence-based ED treatment of OUD, focused initiatives that improve clinician competence with buprenorphine should be explored.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03821103.PMID:35415804 | DOI:10.1007/s13181-022-00890-7
Source: Journal of Medical Toxicology - April 13, 2022 Category: Toxicology Authors: Utsha G Khatri Kathleen Lee Theodore Lin Joseph L D'Orazio Mitesh S Patel Frances S Shofer Jeanmarie Perrone Source Type: research
Buprenorphine Waiver Attitudes Among Primary Care Providers
CONCLUSIONS: Results of our survey suggests that simply removing the mandatory waiver training requirement is insufficient in positively changing attitudes toward buprenorphine prescribing. A key barrier is the perceived lack of institutional support. Future studies investigating effective ways to provide such support may help improve providers' willingness to prescribe buprenorphine.PMID:35822763 | DOI:10.1177/21501319221112272
Source: Primary Care - July 13, 2022 Category: Primary Care Authors: Benjamin Lai Ivana Croghan Jon O Ebbert Source Type: research
Perceptions of buprenorphine barriers and efficacy among nurse practitioners and physician assistants
CONCLUSIONS: Our results suggest that different policies should target perceived barriers affecting waivered versus non-waivered NPs/PAs. Concerns about patient mix suggest stigmatization of patients with OUD. NP/PA education is needed about comparative medication efficaciousness, particularly regarding methadone. Even though many buprenorphine treatment patients benefits from counseling and/or peer support groups, NPs/PAs should be informed that such psychosocial treatment methods are not necessary for all buprenorphine patients.PMID:35945636 | DOI:10.1186/s13722-022-00321-6
Source: Addiction Science and Clinical Practice - August 9, 2022 Category: Addiction Authors: Barbara Andraka-Christou Cory Page Victoria Schoebel Jessica Buche Rebecca L Haffajee Source Type: research
Buprenorphine Continuation During Critical Illness Associated With Decreased Inpatient Opioid Utilization In Individuals Maintained On Buprenorphine For Opioid Use Disorder In A Retrospective Study
This article is protected by copyright. All rights reserved.PMID:37204408 | DOI:10.1002/jcph.2286
Source: The Journal of Clinical Pharmacology - May 19, 2023 Category: Drugs & Pharmacology Authors: Aurora Quaye Chelsea Wampole Richard R Riker David B Seder William J Sauer Janelle M Richard Wendy Y Craig David J Gagnon Source Type: research
Association of Selected State Policies and Requirements for Buprenorphine Treatment With Per Capita Months of Treatment
CONCLUSIONS AND RELEVANCE: In this cross-sectional study of US pharmacy claims, state-mandated educational requirements beyond the initial training required to prescribe buprenorphine were associated with increased buprenorphine use over time. The findings suggest requiring education for buprenorphine prescribers and training in substance use disorder treatment for all controlled substance prescribers as an actionable proposal for increasing buprenorphine use, ultimately serving more patients. No single policy lever can ensure adequate buprenorphine supply; however, policy maker attention to the benefits of enhancing clini...
Source: Pain Physician - May 26, 2023 Category: Anesthesiology Authors: Bradley D Stein Brendan K Saloner Olivia K Golan Barbara Andraka-Christou Christina M Andrews Andrew W Dick Corey S Davis Flora Sheng Adam J Gordon Source Type: research
Development and Validation of a Rapid LC-MS/MS based Method to Quantitate Gabapentin and Buprenorphine in Human Serum
CONCLUSIONS: Concentrations of gabapentin and buprenorphine were determined for 5 authentic human serum samples to further validate the utility of the method and applicable to therapeutic drug monitoring beyond its use as a drug screening assay. Furthermore, new mechanisms for the collision-induced dissociation of gabapentin and buprenorphine have been proposed.PMID:33860565 | DOI:10.1002/rcm.9104
Source: Rapid Communications in Mass Spectrometry : RCM - April 16, 2021 Category: Chemistry Authors: Sarah J Phillips Alison Oliveto Michael J Mancino Howard P Hendrickson Source Type: research
Maternal and fetal buprenorphine pharmacokinetics in pregnant sheep during transdermal patch dosing: Buprenorphine pharmacokinetics in pregnant sheep
CONCLUSIONS: The low transplacental passage of less than one fourth of the ewe's exposure supports buprenorphine as an alternative to methadone in opioid maintenance therapy during pregnancy.PMID:34273481 | DOI:10.1016/j.ejps.2021.105936
Source: European Journal of Pharmaceutical Sciences - July 17, 2021 Category: Drugs & Pharmacology Authors: Henriikka Hakom äki Hannu Kokki Marko Lehtonen Juha R äsänen Hanna-Marja Voipio Veli-Pekka Ranta Merja Kokki Source Type: research
