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Vaccination: Covid Vaccine
Nutrition: Sodium

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Total 45 results found since Jan 2013.

Intranasal administration of sodium nitroprusside augments antigen-specific mucosal and systemic antibody production in mice
In this study, we demonstrated the potent mucosal adjuvant effects of intranasal administration of sodium nitroprusside (SNP), a known nitric oxide (NO) donor, in mice. The results showed that intranasal administration of ovalbumin (OVA) in combination with SNP induced the production of OVA-specific immunoglobulin A in the mucosa and increased serum immunoglobulin G1 levels, indicating a T helper-2 (Th2)-type immune response. However, an analog of SNP, sodium ferrocyanide, which does not generate NO, failed to show any adjuvant effects, suggesting the critical role of NO generation in activating an immune response. In addi...
Source: International Immunopharmacology - May 7, 2023 Category: Allergy & Immunology Authors: Rui Tada Haruka Yamazaki Yuzuho Nagai Yukino Takeda Akihiro Ohshima Jun Kunisawa Yoichi Negishi Source Type: research

Results from a preclinical study in rodents and a Phase 1/2, randomized, double-blind, placebo-controlled, parallel-group study of COVID-19 vaccine S-268019-a in Japanese adults
CONCLUSIONS: The S-268019-a vaccine was not sufficiently immunogenic in Japanese adults despite robust immunogenicity and efficacy in mice. Our results exemplify the innate challenges in translating preclinical data in animals to clinical trials, and highlight the need for continued research to overcome such barriers. (jRCT2051200092).PMID:36572603 | PMC:PMC9755034 | DOI:10.1016/j.vaccine.2022.12.025
Source: Vaccine - December 26, 2022 Category: Allergy & Immunology Authors: Takuhiro Sonoyama Satoshi Iwata Masaharu Shinkai Naoko Iwata-Yoshikawa Nozomi Shiwa-Sudo Takuya Hemmi Akira Ainai Noriyo Nagata Nobuaki Matsunaga Yukio Tada Tomoyuki Homma Shinya Omoto Risa Yokokawa Shibata Kenji Igarashi Tadaki Suzuki Hideki Hasegawa Mar Source Type: research

End of year message from Cochrane ' s CEO, Catherine Spencer
Dear Cochrane Colleagues, Members and Supporters, Thank you to everyone across our community for your dedication and commitment to Cochrane during 2022. The last few years have at times felt tumultuous, both due to Covid and world events, but also because of the changes we are making to ensure that Cochrane is fit for a future that meets our vision of aworld of better health for all people, where decisions about health and care are informed by high-quality evidence. We are well on our way to creating an evolved impact-driven organisation to support evidence-based health and social care. With your help we are building on ...
Source: Cochrane News and Events - December 20, 2022 Category: Information Technology Authors: Muriah Umoquit Source Type: news

Fight Aging! Newsletter, November 14th 2022
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting. Investigating the Ability of Type 2 Diabetes...
Source: Fight Aging! - November 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Hypertonic Saline Use and Traditional Nasal Irrigation: A Possible Preventative Measure against COVID-19
J Contemp Dent Pract. 2022 Apr 1;23(4):379-382.ABSTRACTSaline nasal irrigation (SNI) is a clinically established treatment that has been used to manage upper respiratory infections and allergies; there is also some indication that it may be effective in the setting of coronavirus disease-2019 (COVID-19). The possible advantages of SNI include the following benefits due to the well-known antiviral impact of sodium chloride (NaCl) and the mechanical cleansing effect arising from the irrigation method. First, there will most likely be a decrease in COVID-19 infection rates; second, illness severity will be lowered; and third,...
Source: J Contemp Dent Pract - August 10, 2022 Category: Dentistry Authors: Prashanth Panta Bharat Baruah Shankargouda Patil Source Type: research