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Spatial assessment of triazole organic compounds in surface water from the coastal estuaries to the East China sea
This study reported on the occurrence and distribution of 15 TrOCs in the surface waters of estuaries and the East China sea, and identified the influences of TrOCs originating from the estuarine environment on the ocean. The results showed that the total concentrations of ∑TrOCs in the surface water of estuaries along the coasts of Jiangsu (JS), Zhejiang (ZJ), and Shanghai (SH), China ranged from 0.020 to 104 ng L-1 (7.49 ± 18.2 ng L-1), whereas they ranged from 0.235 to 1.25 ng L-1 (mean 0.711 ± 0.235 ng L-1) in the East China sea. Difenoconazole and tebuconazole were the dominant TrOCs in the estuaries, whereas fenb...
Source: Environmental Pollution - January 16, 2023 Category: Environmental Health Authors: Shengwei Zhang Feng Wang Rui Wang Minghong Cai Source Type: research

Network Medicine in the Age of Biomedical Big Data
Conclusion and Future Directions Above we reviewed a limited set of network medicine philosophies that seek to integrate biomedical big data to uncover meaningful biology. Network medicine approaches provide customized and optimized ways to leverage biomedical data. The choice of the appropriate network method is largely dictated by the underlying biological inquiry, hypotheses, study design, and available data. Although this review is not meant to be exhaustive, our intent was to give a essence of how biomedical data requires a nuanced approach when selecting network analyses and provide a resource for both network scien...
Source: Frontiers in Genetics - April 10, 2019 Category: Genetics & Stem Cells Source Type: research

The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors
Conclusion and Perspectives CYP51 plays a crucial role in fungal invasive growth, hyphae formation and virulence, and inhibitors targeting CYP51 have always been an important component of antifungal agents. Further researches on fungal CYP51s might set about from the following aspects: First, while the detailed crystal structures of several susceptible pathogenic fungi CYP51 have been elaborated, those of drug-resistant variants are still in hypothesis. If those structures were elucidated, targeting at common drug-resistant CYP51 protein variants could probably be promising. Second, it deserves more in-depth researches to...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

What Are Common Presentations for Factitious Disorder?
Discussion Factitious disorder (FD) is when patients fabricate illness in themselves or another person without obvious gain. FD has had other terminology and in the past has been called Munchausen Syndrome (if FD in themselves) or Munchausen Syndrome by proxy or FD by proxy (if FD being perpetuated in another person). The current DSM-V terminology is FD imposed on self or FD imposed on another. Malingering (sometimes referred to as simulation) is similar but those that fabricate illness or medical need have an obvious external reward such as gaining access to public social service benefits, free hospital room and board, or...
Source: PediatricEducation.org - November 2, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

What Are Generalized Anxiety Disorder Treatment Components?
Discussion Generalized anxiety disorder (GAD) is “…excessive anxiety and worry about a number of events and activities coupled with at least one physical symptom, which may include fatigue, poor concentration, restlessness, irritability, muscle tension, and sleep difficulties.” Other ways it presents to the primary care office may be abdominal pain, headache or heart palpitations, dizziness, syncope, numbness, trembling, paresthesia, memory loss, or urinary frequency. It has an estimated prevalence of 15% and is the second most common anxiety disorder in children after social anxiety disorder. GAD can com...
Source: PediatricEducation.org - March 15, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Causal analysis of the temperature impact on deep-sea biodiversity
Biol Lett. 2021 Jul;17(7):20200666. doi: 10.1098/rsbl.2020.0666. Epub 2021 Jul 21.ABSTRACTThe deep sea comprises more than 90% of the ocean; therefore, understanding the controlling factors of biodiversity in the deep sea is of great importance for predicting future changes in the functioning of the ocean system. Consensus has recently been increasing on two plausible factors that have often been discussed as the drivers of deep-sea species richness in the contexts of the species-energy and physiological tolerance hypotheses: (i) seafloor particulate organic carbon (POC) derived from primary production in the euphotic zone...
Source: Biology Letters - July 20, 2021 Category: Biology Authors: Hideyuki Doi Moriaki Yasuhara Masayuki Ushio Source Type: research

Pediatric exposure to endocrine disruptors and carcinogenic, mutagenic or reprotoxic substances by pharmaceutical forms intended for the cutaneous route: regulatory provisions in France, in Europe, and state of the art of scientific knowledge
CONCLUSION: The health professional must be able to develop a critical mind on such substances in order to inform and promote therapeutic adherence, guaranteeing the safety of the child's care.PMID:34481784 | DOI:10.1016/j.pharma.2021.08.008
Source: Annales Pharmaceutiques Francaises - September 5, 2021 Category: Drugs & Pharmacology Authors: Trouillard Alexandre Sabri Amna Prot-Labarthe Sonia Storme Thomas Bourrat Emmanuelle Soulairol Ian Source Type: research

Transcriptomic evidences for microbial carbon and nitrogen cycles in the deoxygenated seawaters of Bohai Sea
Environ Int. 2021 Oct 4;158:106889. doi: 10.1016/j.envint.2021.106889. Online ahead of print.ABSTRACTEutrophication-induced water deoxygenation occurs continually in coastal oceans, and alters community structure, metabolic processes, and the energy shunt, resulting in a major threat to the ecological environment. Seasonal deoxygenation events have occurred in the Bohai Sea (China), however, how these affect the functional activity of microorganisms remains unclear. Here, through the use of absolute quantification of 16S rRNA genes amplicon sequencing and metatranscriptomics approaches, we investigated the structure of the...
Source: Environment International - October 7, 2021 Category: Environmental Health Authors: Yu Han Mu Zhang Xiaofeng Chen Weidong Zhai Ehui Tan Kai Tang Source Type: research

Carcinoecium-Forming Sea Anemone < em > Stylobates calcifer < /em > sp. nov. (Cnidaria, Actiniaria, Actiniidae) from the Japanese Deep-Sea Floor: A Taxonomical Description with Its Ecological Observations
This study is perhaps the first observation of the behavioral interaction of the rarely studied carcinoecium-forming mutualism in the deep sea.PMID:35580031 | DOI:10.1086/719160
Source: The Biological Bulletin - May 17, 2022 Category: Biology Authors: Akihiro Yoshikawa Takato Izumi Takeya Moritaki Taeko Kimura Kensuke Yanagi Source Type: research