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Pilot-scale production of inactivated monoglycosylated split H < sub > 1 < /sub > N < sub > 1 < /sub > influenza virus vaccine provides cross-strain protection against influenza viruses
This study demonstrated that IVR-190mg produced using a pilot-scale manufacturing process elicits comprehensive cross-strain immune responses that have great potential to substantially mitigate the need for yearly reformulation of strain-specific inactivated vaccines.PMID:37263355 | DOI:10.1016/j.antiviral.2023.105640
Source: Antiviral Research - June 1, 2023 Category: Virology Authors: Chia-Ying Wu Shao-En Kao Yung-Chieh Tseng Yu-Po Lin Jen-Tzu Hou Li-Yang Wu Sharon Chiu Che Alex Ma Pei-Wen Hsiao Jane Hsiao Juine-Ruey Chen Source Type: research

Risk of Guillain-Barr é Syndrome Among Older Adults Receiving Influenza Vaccine in Taiwan
CONCLUSIONS AND RELEVANCE: These findings suggest that influenza vaccination did not increase the risk of GBS among adults aged 65 years or older in Taiwan regardless of postvaccination period or underlying characteristics.PMID:36129709 | DOI:10.1001/jamanetworkopen.2022.32571
Source: Cancer Control - September 21, 2022 Category: Cancer & Oncology Authors: Cheng-Chang Yen Kai-Che Wei Wen-Hwa Wang Yu-Tung Huang Yu-Chia Chang Source Type: research

Influenza vaccine and subsequent development of zoster
CONCLUSIONS: There was a slight increase in risk of HZ in people receiving influenza vaccine in the first 1-15 days after vaccination.PMID:36114790 | DOI:10.1111/irv.13055
Source: Herpes - September 17, 2022 Category: Infectious Diseases Authors: Kai-Che Wei Yu-Chia Chang Yu-Tung Huang Source Type: research

Impact of prior infection and repeated vaccination on post-vaccination antibody titers of the influenza A(H1N1)pdm09 strain in Taiwan schoolchildren: Implications for public health
CONCLUSION: This study supports the implementation of annual mass-vaccination with A(H1N1)pdm09 in schoolchildren for three consecutive influenza seasons when vaccine and circulating strains were well matched, and found that prior infection and pre-vaccination HI-Ab levels positively impacted post-vaccination HI-Ab responses.PMID:35525727 | DOI:10.1016/j.vaccine.2022.03.047
Source: Vaccine - May 7, 2022 Category: Allergy & Immunology Authors: Wei Liu Yu-Hui Lien Ping-Ing Lee Ta-Chien Chan Lih-Chiann Wang Chin-Rur Yang Mei-Shang Ho Juine-Ruey Chen Chia-Chi Ku Chwan-Chuen King Source Type: research

Universal influenza vaccine based on conserved antigens provides long-term durability of immune responses and durable broad protection against diverse challenge virus strains in mice
Vaccine. 2021 Jul 2:S0264-410X(21)00833-1. doi: 10.1016/j.vaccine.2021.06.072. Online ahead of print.ABSTRACTCurrent influenza vaccines rely on inducing antibody responses to the rapidly evolving hemagglutinin (HA) and neuraminidase (NA) proteins, and thus need to be strain-matched. However, predictions of strains that will circulate are imperfect, and manufacturing of new vaccines based on them takes months. As an alternative, universal influenza vaccines target highly conserved antigens. In proof of concept studies of universal vaccine candidates in animal models challenge is generally conducted only a short time after v...
Source: Vaccine - July 6, 2021 Category: Allergy & Immunology Authors: Chia-Yun Lo Julia A Misplon Xing Li Graeme E Price Zhiping Ye Suzanne L Epstein Source Type: research